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Effects of adlay on azoxymethane-induced colon carcinogenesis in rats
Food and Chemical Toxicology, 2004Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a grass crop used in traditional Chinese medicine and as a nutritious food. It has been reported that adlay has anti-inflammatory and anti-tumor activity. Cyclooxygenase-2 (COX-2) is an inducible enzyme functionally related to both inflammation and colon carcinogenesis and is the target of many ...
Min-Liang Kuo +2 more
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The effect of deuterium substitution on carcinogenesis by azoxymethane
Cancer Letters, 1984Azoxymethane was synthesized labeled with deuterium in one or other of the two methyl groups. Groups of 20 male F344 rats were given either 4 mg or 1 mg per week of each of the labeled compounds or of unlabeled azoxymethane each week in drinking water, for 30 weeks, after which the animals were kept until they died.
W, Lijinsky, M D, Reuber, J E, Saavedra
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Transglutaminase in azoxymethane-induced colon cancer in the rat
Digestive Diseases and Sciences, 1995A widespread from of transglutaminase, tissue transglutaminase, has been identified in a number of mammalian cell types, both normal and transformed cells; its biological role is not well understood. We investigated the effect of experimentally induced colon cancer on transglutaminase activity in the rat. Azoxymethane (15 mg/kg for six weeks), given by
G. D'ARGENIO +7 more
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Inhibition of azoxymethane-induced intestinal cancer by disulfiram
Cancer Letters, 1978Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced from 100% to 60%.
N D, Nigro, R L, Campbell
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Inhibition of carcinogenicities of 1,2-dimethylhydrazine and azoxymethane by pyrazole
Cancer Letters, 1982Inhibitory effects of pyrazole on the carcinogenicities of 2 large-bowel carcinogens, 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM), were examined, because our previous study revealed that pyrazole completely inhibited the induction of mutations by these carcinogens in the host-mediated mutation assay.
M, Moriya, T, Harada, Y, Shirasu
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Hypergastrinemia in rats with azoxymethane‐induced colon cancers
International Journal of Cancer, 1995AbstractGastrin has been suggested to be involved in the promotion and progression of colon cancer. Mice colon cancers and colon‐carcinoma cell lines are stimulated to grow by gastrin, and gastrin receptors have been found in the majority of human colon‐tumor specimens.
L, D'Agostino +9 more
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Effect of tea on the formation of DNA adducts by azoxymethane
Xenobiotica, 19981. The effect of black tea on the conversion of azoxymethane (AOM) to DNA reactive metabolites was studied in four groups of the male F344 rat. Each received 1.25% solutions of tea for 2 or 6 weeks, and simultaneous controls drank water. All rats were injected s.c. twice with 15 mg/kg AOM after the first or fifth week respectively, on tea or water, and
W, Chen +3 more
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Effect of docosahexaenoic acid on azoxymethane-induced colon carcinogenesis in rats
Cancer Letters, 1994The effect of intragastric gavage administration of docosahexaenoic acid (DHA) on azoxymethane (AOM)-induced colon carcinogenesis in rats was studied. Male F344 rats were treated s.c. with 15 mg/kg of AOM once a week for 2 weeks and were given either 0.7 ml of DHA or water intragastrically twice a week starting the day before the first carcinogen ...
Toshinari Minamoto +2 more
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