Results 141 to 150 of about 8,111 (184)
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ChemInform Abstract: Synthesis of Vinyloxy‐NNO‐azoxymethane.
ChemInform, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
I. N. Zyuzin, G. N. Nechiporenko
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The Azoxymethane/Il10 −/− Model of Colitis-Associated Cancer (CAC)
2019Mouse models have proved essential for generating a mechanistic understanding of human disease processes. The azoxymethane/interleukin-10 knockout (AOM/Il10-/-) model is a powerful tool for assessing the effects of intestinal microbiota and inflammation on colon tumorigenesis.
Aaron, Rothemich, Janelle C, Arthur
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Neurobiological characterization of an azoxymethane mouse model of acute liver failure
Neurochemistry International, 2006Molecular biological approaches continue to lead to the identification of alterations in expression of genes coding for key central nervous system proteins involved in water homeostasis, energy metabolism and neurotransmitter regulation in acute liver failure (ALF).
Mireille, Bélanger +2 more
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Aging alters acute apoptotic response to azoxymethane in the colon of rats
Experimental Gerontology, 2007Deregulation of apoptosis seems to contribute to the aging process in post-mitotic tissues. However, the effect of aging on regulation of apoptosis in the colon is largely unknown. We induced colonic apoptosis using azoxymethane (AOM) in three different aged (6 week, 12 month, and 22 month) F344 rats and assessed age-related differences in induction ...
Youngjoo, Kwon, Bernadene A, Magnuson
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Effect of dietary cholesterol on azoxymethane-induced colon carcinogenesis in rats
Carcinogenesis, 1983The effect of dietary cholesterol on azoxymethane (AOM)-induced colon carcinogenesis was evaluated with two different sets of experiments. Starting at 6 weeks of age, male Donryu rats were divided into four groups, and fed either control chow or one supplemented with 1% cholesterol, and with or without AOM (11 weekly s.c.
Y, Hiramatsu +5 more
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Secondary effects induced by the colon carcinogen azoxymethane in BDIX rats
APMIS, 2004Azoxymethane (AOM) is claimed to be a colon‐specific carcinogen. In our studies, AOM was administered to adult BDIX/OrlIco rats by four weekly subcutaneous injections of 15 mg/kg body weight each – two periods of 2 weeks of AOM treatment separated by a one‐week break.
Kobaek-Larsen, Morten +2 more
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Beer Inhibition of Azoxymethane-Induced Colonic Carcinogenesis
2009Abstract Modulatory effects of beer intake on azoxymethane (AOM)-induced rat colonic carcinogenesis in male Fischer 344 rats were investigated. Single cell gel electrophoresis assay indicated that DNA damage of colonocytes, induced by a single AOM injection (15 mg/kg body weight), was significantly reduced in rats fed beer or malt extract for 2 ...
Hajime Nozawa, Keiji Kondo
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Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1
Carcinogenesis, 1991The metabolism of azoxymethane (AOM), methylazoxymethanol (MAM) and N-nitrosodimethylamine (NDMA) by liver microsomes from acetone-induced rats as well as by a reconstituted system containing purified cytochrome P450IIE1 was examined. The products consisted of MAM from AOM; methanol and formic acid from MAM; and methylamine, formaldehyde, methanol ...
O S, Sohn +3 more
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Age-related changes in biotransformation of azoxymethane and methylazoxymethanolin vitro
Xenobiotica, 19901. Age-related changes in hepatic hydroxylation of azoxymethane (AZO) to methylazoxymethanol (MAM), as well as colonic phase I metabolism of MAM by alcohol dehydrogenase (ADH) were examined in young (2-4 months), middle-aged (12-14 months), and old (22-24 months) male Fischer 344 rats.
T F, McMahon +3 more
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Chemoprevention by amiloride of experimental carcinogenesis in rat colon induced by azoxymethane
Carcinogenesis, 1995The effects of amiloride on the incidence and histology of colon tumors induced by azoxymethane, on the labeling index of the colon mucosa and on the activity of ornithine decarboxylase in the colon wall were investigated in Wistar rats. Rats received 10 weekly injections of 7.4 mg/kg body wt azoxymethane and s.c.
M, Tatsuta +4 more
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