Results 261 to 270 of about 21,150 (298)

Dietary Iron Promotes Azoxymethane-Induced Colon Tumors in Mice

Nutrition and Cancer, 2004
There is accumulating evidence that high levels of dietary iron may play a role in colon carcinogenesis. We used a mouse model to investigate the impact of elevated dietary iron on incidence of aberrant crypt foci (ACF; a preneoplastic lesion) on tumor formation and on induction of oxidative stress. A/J mice were injected intraperitoneally, once a week
Jillian N M, Ilsley, Glenn S, Belinsky, Kishore, Guda, Qi, Zhang, Xi, Huang, Jeffrey B, Blumberg, Paul E, Milbury, L Jackson, Roberts, Richard G, Stevens, Daniel W, Rosenberg   +9 more
openaire   +2 more sources

The Azoxymethane/Il10 −/− Model of Colitis-Associated Cancer (CAC)

2019
Mouse models have proved essential for generating a mechanistic understanding of human disease processes. The azoxymethane/interleukin-10 knockout (AOM/Il10-/-) model is a powerful tool for assessing the effects of intestinal microbiota and inflammation on colon tumorigenesis.
Aaron, Rothemich, Janelle C, Arthur
openaire   +2 more sources

Factor VIII expression in azoxymethane-induced murine fulminant hepatic failure

Blood, 2002
AbstractFulminant hepatic failure (FHF) in humans produces a bleeding diathesis due in large part to a reduction in the biosynthesis of liver-derived coagulation factors. Remarkably, factor VIII procoagulant activity is elevated in most of these patients despite widespread liver cell death.
Christopher B, Doering, Cassandra D, Josephson, Heather N, Craddock, Pete, Lollar   +3 more
openaire   +2 more sources

Effects of adlay on azoxymethane-induced colon carcinogenesis in rats

Food and Chemical Toxicology, 2004
Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a grass crop used in traditional Chinese medicine and as a nutritious food. It has been reported that adlay has anti-inflammatory and anti-tumor activity. Cyclooxygenase-2 (COX-2) is an inducible enzyme functionally related to both inflammation and colon carcinogenesis and is the target of many ...
Chun-Kuang, Shih, Wenchang, Chiang, Min-Liang, Kuo   +2 more
openaire   +2 more sources

Beer Inhibition of Azoxymethane-Induced Colonic Carcinogenesis

2009
Abstract Modulatory effects of beer intake on azoxymethane (AOM)-induced rat colonic carcinogenesis in male Fischer 344 rats were investigated. Single cell gel electrophoresis assay indicated that DNA damage of colonocytes, induced by a single AOM injection (15 mg/kg body weight), was significantly reduced in rats fed beer or malt extract for 2 ...
Hajime Nozawa, Keiji Kondo
openaire   +1 more source

Mixed Tocopherols Inhibit Azoxymethane-Induced Aberrant Crypt Foci in Rats

Nutrition and Cancer, 2006
Gamma (gamma) tocopherol, but not alpha (alpha) tocopherol (vitamin E), has previously been reported as an effective inhibitor of cyclooxygenase (COX) enzyme activity. In a pilot study of 17 rats, mixed tocopherols containing more than 50% gamma-tocopherol, added at 0.1% to an AIN-76A diet, produced a significant inhibition (about 55%) of azoxymethane ...
Harold L, Newmark, Mou-Tuan, Huang, Bandaru S, Reddy   +2 more
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Dry Beans Inhibit Azoxymethane-Induced Colon Carcinogenesis in F344 Rats

The Journal of Nutrition, 1997
Epidemiological studies show a low incidence of colon cancer in many Latin American countries where the consumption of dry beans (e.g., pinto) is high. The purpose of this study was to use rats as an animal model to obtain experimental data on the inhibition of colon carcinogenesis by dry beans.
J S, Hughes, C, Ganthavorn, S, Wilson-Sanders   +2 more
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Inhibition of carcinogenicities of 1,2-dimethylhydrazine and azoxymethane by pyrazole

Cancer Letters, 1982
Inhibitory effects of pyrazole on the carcinogenicities of 2 large-bowel carcinogens, 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM), were examined, because our previous study revealed that pyrazole completely inhibited the induction of mutations by these carcinogens in the host-mediated mutation assay.
M, Moriya, T, Harada, Y, Shirasu
openaire   +2 more sources

Enhancement of azoxymethane‐induced colon carcinogenesis in spontaneously hypertensive rats

International Journal of Cancer, 1990
AbstractThe incidence, number, location, and histological types of colon tumors induced by azoxymethane (AOM) and the tissue norepinephrine concentration of the colon wall were investigated in spontaneously hypertensive (SH) rats and in control normotensive Wistar Kyoto (WKY) rats. All rats received 10 weekly s.c. injections of AOM.
M, Tatsuta, H, Iishi, M, Baba, H, Taniguchi   +3 more
openaire   +2 more sources

Citrus nobiletin inhibits azoxymethane‐induced large bowel carcinogenesis in rats

BioFactors, 2004
AbstractThe inhibitory effects of dietary feeding of citrus nobiletin on azoxymethane (AOM)‐induced rat colon carcinogenesis using a long‐term bioassay were investigated. Five‐week old male F344 rats were initiated with two weekly subcutaneous injections of AOM (20 mg/kg bw) to induce colonic tumors. They were also given the diets containing 0.01% or 0.
Rikako, Suzuki, Hiroyuki, Kohno, Akira, Murakami, Koichi, Koshimizu, Hajime, Ohigashi, Masamichi, Yano, Harukuni, Tokuda, Hoyoku, Nishino, Takuji, Tanaka   +8 more
openaire   +2 more sources