Results 271 to 280 of about 21,150 (298)

Quantitative assessment of azoxymethane-inducedaberrant crypt foci in inbred mice

Experimental and Molecular Pathology, 1999
Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk.
D A, Delker, Q S, Wang, A, Papanikolaou, H E, Whiteley, D W, Rosenberg   +4 more
openaire   +2 more sources

Neurobiological characterization of an azoxymethane mouse model of acute liver failure

Neurochemistry International, 2006
Molecular biological approaches continue to lead to the identification of alterations in expression of genes coding for key central nervous system proteins involved in water homeostasis, energy metabolism and neurotransmitter regulation in acute liver failure (ALF).
Mireille, Bélanger, Jean, Côté, Roger F, Butterworth   +2 more
openaire   +2 more sources

Differential Expression of p16INK4a in Azoxymethane-Induced Mouse Colon Tumorigenesis

Molecular Carcinogenesis, 2000
Alterations in the p16(INK4a) gene have been implicated in the pathogenesis of different human cancers and animal tumors. We postulated that alterations in the p16(INK4a) gene may also be involved in mouse colon tumorigenesis induced by the chemical carcinogen azoxymethane (AOM).
Q S, Wang, A, Papanikolaou, P R, Nambiar, D W, Rosenberg   +3 more
openaire   +2 more sources

Dietary Guar Gum Alters Colonic Microbial Fermentation in Azoxymethane-Treated Rats

The Journal of Nutrition, 1996
To assess the effects of guar gum on colonic microbial fermentation and cancer development, azoxymethane-treated rats were fed a partially hydrolyzed guar or control diet. Anaerobic fecal incubations were conducted at 8-wk intervals, either without added substrate or with cornstarch or hydrolyzed guar as substrates.
G A, Weaver, C, Tangel, J A, Krause, H D, Alpern, P L, Jenkins, M M, Parfitt, J J, Stragand   +6 more
openaire   +2 more sources

Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1

Carcinogenesis, 1991
The metabolism of azoxymethane (AOM), methylazoxymethanol (MAM) and N-nitrosodimethylamine (NDMA) by liver microsomes from acetone-induced rats as well as by a reconstituted system containing purified cytochrome P450IIE1 was examined. The products consisted of MAM from AOM; methanol and formic acid from MAM; and methylamine, formaldehyde, methanol ...
O S, Sohn, H, Ishizaki, C S, Yang, E S, Fiala   +3 more
openaire   +2 more sources

Effect of tea on the formation of DNA adducts by azoxymethane

Xenobiotica, 1998
1. The effect of black tea on the conversion of azoxymethane (AOM) to DNA reactive metabolites was studied in four groups of the male F344 rat. Each received 1.25% solutions of tea for 2 or 6 weeks, and simultaneous controls drank water. All rats were injected s.c. twice with 15 mg/kg AOM after the first or fifth week respectively, on tea or water, and
W, Chen, O S, Sohn, E S, Fiala, J H, Weisburger   +3 more
openaire   +2 more sources

Secondary effects induced by the colon carcinogen azoxymethane in BDIX rats

APMIS, 2004
Azoxymethane (AOM) is claimed to be a colon‐specific carcinogen. In our studies, AOM was administered to adult BDIX/OrlIco rats by four weekly subcutaneous injections of 15 mg/kg body weight each – two periods of 2 weeks of AOM treatment separated by a one‐week break.
Kobaek-Larsen, Morten, Fenger, Claus, Ritskes-Hoitinga, Jelmera   +2 more
openaire   +3 more sources

Kinetics of methoxy-NNO-Azoxymethane hydrolysis in strong acids

Kinetics and Catalysis, 2011
The kinetics of methoxy-NNO-azoxymethane (I) hydrolysis in concentrated solutions of strong acids (HBr, HCl, HClO4, and H2SO4) has been investigated by a manometric method. The gas evolution rate is described by the equation corresponding to two consecutive first-order reactions, with the rate constant of the second reaction considerably exceeding the ...
I. N. Zyuzin, D. B. Lempert
openaire   +1 more source

Azoxymethane/Dextran Sodium Sulfate (AOM/DSS) Model of Colorectal Cancer

Recent progress in developing new vaccination strategies against cancer requires the production of complex and reliable animal models reflecting the complexity of the tumors with their microenvironment. Mice can be considered a good source due to low cost and ease of being genetically modified, inoculated with tumor cell lines or treated by chemicals ...
De Robertis Mariangela, Signori Emanuela
openaire   +4 more sources

Synthesis of vinyloxy-NNO-azoxymethane

Russian Chemical Bulletin, 1998
I. N. Zyuzin, G. N. Nechiporenko
openaire   +1 more source