Results 51 to 60 of about 9,189 (185)

Comparative evaluation of disc diffusion and broth microdilution methods for aztreonam/avibactam susceptibility testing in Enterobacterales. [PDF]

J Antimicrob Chemother
Abstract Background Aztreonam/avibactam is a novel β-lactam/β-lactamase inhibitor (BL/BLI) combination active against carbapenem-resistant Enterobacterales (CRE), including MBL-producing isolates. In May 2024, EUCAST published Enterobacterales breakpoints for aztreonam/avibactam.
Baltas I, Tsakri D, Vourli S, Solanki H, Murrell E, Kiousi E, Tsakris Z, Kuczmar G, Smyrni N, Skiadas I, Grammelis V, Hatcher J, Menegas D, Tsakris A, Vrioni G, Grandjean L.   +15 more
europepmc   +3 more sources

Genomic epidemiology and aztreonam-avibactam resistance mechanisms of Proteus mirabilis in china: an eight-year retrospective study. [PDF]

Ann Clin Microbiol Antimicrob
Proteus mirabilis has emerged as an important multidrug-resistant opportunistic pathogen, with the production of metallo-β-lactamases (MBLs) being a major contributor to its broad-spectrum resistance. Although the aztreonam-avibactam (ATM-AVI) combination represents a key therapeutic option against MBL-producing Enterobacteriaceae, the mechanisms ...
Guo J, Wu C, Tang X, Wang L, Qi Y, Yu Y, Tu Y, Zhang L, Li X.   +8 more
europepmc   +3 more sources

Pragmatic options for dose optimization of ceftazidime/avibactam with aztreonam in complex patients

, 2021
Avibactam is a β-lactamase inhibitor that is combined with aztreonam against Enterobacterales co-expressing serine- and metallo-β-lactamases (MBL). Optimal dosing of aztreonam with avibactam is not well-defined in critically ill patients and contingent ...
Tiseo, Giusy, Menichetti, Francesco, Cattaneo, Dario, Pai, Manjunath P, Leonildi, Alessandro, Di Paolo, Antonello, Baldelli, Sara, Galfo, Valentina, Falcone, Marco, Tagliaferri, Enrico   +9 more
core   +1 more source

In Vitro Activities of Aztreonam-Avibactam, Eravacycline, Cefoselis, and Other Comparators against Clinical Enterobacterales Isolates: a Multicenter Study in China, 2019

Microbiology Spectrum, 2023
Aztreonam-avibactam, eravacycline, and cefoselis are three novel antimicrobial agents for the treatment of serious infections caused by Gram-negative bacteria. We evaluated the in vitro activities of the above-mentioned three antimicrobial agents against
Jiawei Chen, Yong Liu, Wei Jia, Xuesong Xu, Guizhen Sun, Tong Wang, Jin Li, Ge Zhang, Ran Jing, Hongli Sun, Yingchun Xu, Yali Liu   +11 more
doaj   +1 more source

A multicenter performance evaluation of aztreonam-avibactam gradient diffusion susceptibility testing for <i>Enterobacterales</i>. [PDF]

J Clin Microbiol
ABSTRACT Aztreonam-avibactam (AZA) is a new monobactam/beta-lactamase inhibitor combination that recently received regulatory approval in the United States (U.S.) and Europe.
Bui TI, Csiki-Fejer E, Prudhomme S, Bossy L, Hardy DJ, Wootton M, Zambardi G, Yarbrough ML.   +7 more
europepmc   +2 more sources

Occurrence of Aztreonam-Avibactam-Resistant NDM-5-Producing Escherichia coli in the Food Chain

Antimicrobial Agents and Chemotherapy, 2021
Among the most common metallo-β-lactamases (MBL), the most clinically significant are the New Delhi Metallo-β-lactamases (NDM). NDM enzymes hydrolyze almost all β-lactams except aztreonam and are not inhibited by novel β-lactamase inhibitors such as avibactam (AVI), relebactam, and vaborbactam (1).….
Mustafa Sadek, Laurent Poirel, Patrice Nordmann   +2 more
openaire   +3 more sources

In vitro efficacy of ceftazidime-avibactam, aztreonam-avibactam and other rescue antibiotics against carbapenem-resistant Enterobacterales from the Arabian Peninsula

International Journal of Infectious Diseases, 2020
Objectives: Our aim was to assess the susceptibility of carbapenem-resistant Enterobacterales (CRE) from the Arabian Peninsula to a broad spectrum of antibiotics, including fosfomycin, ceftazidime-avibactam, and aztreonam-avibactam.
Ágnes Sonnevend, Akela Ghazawi, Dania Darwish, Greeshma Barathan, Rayhan Hashmey, Tanveer Ashraf, Tahir A. Rizvi, Tibor Pál   +7 more
doaj   +1 more source

In Vitro Activity of Auranofin in Combination With Aztreonam-Avibactam Against Metallo-β-lactamase (MBL)-Producing Enterobacterales [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
ObjectivesTo assess the efficacy of aztreonam-avibactam-auranofin (ATM-AVI-AUR) against a collection of 88 carbapenemase-producing Enterobacterales (CPE) clinical isolates and 6 in vitro selected ATM-AVI-resistant CPE with CMY-16 Tyr150Ser and Asn346His mutants or transformants.MethodsMICs of imipenem, ceftazidime-avibact8am (CAZ-AVI), ATM-AVI, CAZ-AVI-
Wen Wang, Wen Wang, Shifeng Huang, Chunhong Zou, Chunhong Zou, Yanhui Ding, Huijuan Wang, Shuli Pu, Yunfeng Liao, Hong Du, Deqiang Wang, Deqiang Wang, Liang Chen, Liang Chen, Siqiang Niu   +14 more
openaire   +3 more sources

Klebsiella pneumoniae Mutants Resistant to Ceftazidime-Avibactam Plus Aztreonam, Imipenem-Relebactam, Meropenem-Vaborbactam, and Cefepime-Taniborbactam [PDF]

, 2022
We show that a previously described Klebsiella pneumoniae variant that is resistant to ceftazidime-avibactam plus meropenem-vaborbactam, has a ramR plus ompK36 mutation, and produces the V239G variant KPC-3 (V240G per the standard numbering system ...
Avison, Matthew B, Satapoomin, Aim, Dulyayangkul, Punyawee   +2 more
core   +1 more source

Presentation_1_Resistance to aztreonam-avibactam due to CTX-M-15 in the presence of penicillin-binding protein 3 with extra amino acids in Escherichia coli.PDF

, 2022
Aztreonam-avibactam is a promising combination to treat carbapenem-resistant Enterobacterales including coverage for metallo-β-lactamases. Escherichia coli strains resistant to aztreonam-avibactam have emerged but resistance mechanisms remain to be ...
Ke Ma (260231), Zhiyong Zong (237098)
core   +1 more source