Occurrence of Aztreonam-Avibactam-Resistant NDM-5-Producing Escherichia coli in the Food Chain
Antimicrobial Agents and Chemotherapy, 2021 Among the most common metallo-β-lactamases (MBL), the most clinically significant are the New Delhi Metallo-β-lactamases (NDM). NDM enzymes hydrolyze almost all β-lactams except aztreonam and are not inhibited by novel β-lactamase inhibitors such as avibactam (AVI), relebactam, and vaborbactam (1).….
Mustafa Sadek +2 more
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The 2018 Garrod Lecture: Preparing for the Black Swans of Resistance [PDF]
, 2018 The need for governments to encourage antibiotic development is widely agreed, with ‘Market Entry Rewards’ being suggested. Unless these are to be spread widely – which is unlikely given the $1 billion sums proposed– we should be wary, for this approach ...
Livermore, David
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Pilot Program for Aztreonam-Avibactam Susceptibility Testing of Metallo-Beta-Lactamase-Producing Enterobacteriaceae [PDF]
Infection Control & Hospital Epidemiology, 2020 Background: Carbapenemase-producing Enterobacteriaceae (CPE) are a major public health concern because they typically display multidrug resistance and they cause hard-to-treat infections. Organisms harboring metallo-β-lactamases (MBLs) pose a critical challenge in clinical practice because they confer resistance to nearly all β-lactams, including ...
Amelia Bhatnagar +7 more
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Activity of OP0595-β-lactam combination against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactama [PDF]
, 2015 Background: OP0595 is a diazabicyclooctane that (i) acts as a PBP2-ctive antibacterial, (ii) inhibits Class A and C β-lactamases and (iii), like mecillinam, gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.
Livermore, David M. +3 more
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Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates [PDF]
Antimicrobial Agents and Chemotherapy, 2018 ABSTRACT A total of 10,451 contemporary (2016) Enterobacteriaceae isolates from 84 U.S. medical centers and 116 metallo-β-lactamase- and/or OXA-48-like-producing Enterobacteriaceae isolates from other countries were tested against aztreonam-avibactam and comparators.
Helio S, Sader +5 more
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Antimicrobial-resistant Gram-negative infections in neonates: burden of disease and challenges in treatment. [PDF]
, 2017 PURPOSE OF REVIEW: This review summarizes the main challenges of antimicrobial resistance (AMR) in the neonatal population with a special focus on multidrug-resistant (MDR) Gram-negative pathogens.
Bielicki, J +3 more
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An Epidemiological and Pharmacokinetic-pharmacodynamic Investigation into the Impact of Carbapenem-resistant Enterobacterales [PDF]
, 2023 Background: According to the 2019 CDC Antibiotic Resistance Threats Report, more than 2.8 million antibiotic-resistant infections occur in the United States each year, leading to more than 35,000 deaths.
Clark, Justin
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Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam [PDF]
Clinical Microbiology and Infection, 2019 Checkerboard experiments followed by fractional inhibitory concentration (FIC) index determinations are commonly used to assess in vitro pharmacodynamic interactions between combined antibiotics, but FIC index cannot be determined in case of antibiotic/non-active compound combinations.
Chauzy, Alexia +5 more
openaire +3 more sources
Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults [PDF]
, 2022 Klebsiella pneumoniae; Cefiderocol; Nosocomial pneumoniaKlebsiella pneumoniae; Cefiderocol; Neumonía nosocomialKlebsiella pneumoniae; Cefiderocol; Pneumònia nosocomialInfections due to Klebsiella pneumoniae have been increasing in intensive care units ...
Bou, German +7 more
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Microbiology Spectrum, 2023 Aztreonam-avibactam, eravacycline, and cefoselis are three novel antimicrobial agents for the treatment of serious infections caused by Gram-negative bacteria. We evaluated the in vitro activities of the above-mentioned three antimicrobial agents against
Jiawei Chen +11 more
doaj +1 more source