Results 1 to 10 of about 25,663 (196)

In Vitro Susceptibility of Aztreonam-Vaborbactam, Aztreonam-Relebactam and Aztreonam-Avibactam Associations against Metallo-β-Lactamase-Producing Gram-Negative Bacteria

Antibiotics, 2023
Background: Despite the availability of new options (ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam and cefiderocol), it is still very difficult to treat infections caused by metallo-β-lactamase (MBLs)-producers resistant to aztreonam.
Laurent Dortet, Cecile Emeraud, Sandrine Bernabeu   +2 more
exaly   +4 more sources

Insight into the Interaction Mechanism of HSA with Aztreonam: A Multispectroscopic and Computational Approach

Molecules, 2022
Aztreonam is a Gram-negative bacteria-targeting synthetic monobactam antibiotic. Human serum albumin (HSA) plays an important role in the transference of pharmaceuticals, hormones, and fatty acids, along with other compounds, determining their ...
Altaf Khan
exaly   +4 more sources

Outbreak of aztreonam–avibactam-resistant NDM-5-producing Escherichia coli isolates in a hospital of Paris [PDF]

Microbiology Spectrum
The emergence of aztreonam–avibactam resistance among NDM-producing Escherichia coli represents a major therapeutic and infection control concern. Four cases of aztreonam–avibactam-resistant (AZAR) NDM-producing E.
Véronique Faraut Derouin, Bérénice Souhail, Caroline Charlier, Sébastien Gaultier, Etienne Canoui, Anne Sorieul, Daria Menuet, Hélène Poupet, Laurence Armand-Lefèvre, Eve-Marie Walle, Delphine Desbois, Alexandra Doloy, Philippe C. Morand, Claire Poyart, Romain Coriat, Asmaa Tazi, Hedi Mammeri   +16 more
doaj   +2 more sources

In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes

Microbiology Spectrum, 2021
Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated in vitro activity against 341 recent clinical isolates.
David R. Snydman, Laura McDermott
doaj   +1 more source

Detecting KPC-2 and NDM-1 Coexpression in Klebsiella pneumoniae Complex from Human and Animal Hosts in South America

Microbiology Spectrum, 2022
Reports of Gram-negative bacteria harboring multiple carbapenemase genes have increased in South America, leading to an urgent need for appropriate microbiological diagnosis.
Felipe Vásquez-Ponce, Karine Dantas, Johana Becerra, Gregory Melocco, Fernanda Esposito, Brenda Cardoso, Larissa Rodrigues, Keila Lima, Aline V. de Lima, Fábio P. Sellera, Renata Mattos, Lucas Trevisoli, Marco A. Vianello, Thais Sincero, Jose Di Conza, Eliana Vespero, Gabriel Gutkind, Jorge Sampaio, Nilton Lincopan   +18 more
doaj   +1 more source

Resistance to aztreonam-avibactam due to CTX-M-15 in the presence of penicillin-binding protein 3 with extra amino acids in Escherichia coli

Frontiers in Microbiology, 2022
Aztreonam-avibactam is a promising combination to treat carbapenem-resistant Enterobacterales including coverage for metallo-β-lactamases. Escherichia coli strains resistant to aztreonam-avibactam have emerged but resistance mechanisms remain to be ...
Ke Ma, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +3 more
doaj   +1 more source

Treatment of Severe Infections Due to Metallo-Betalactamases Enterobacterales in Critically Ill Patients

Antibiotics, 2022
Metallo-beta-lactamases-producing (MBL) Enterobacterales is a growing problem worldwide. The optimization of antibiotic therapy is challenging. The pivotal available therapeutic options are either the combination of ceftazidime/avibactam and aztreonam or
Jean-François Timsit, Paul-Henri Wicky, Etienne de Montmollin   +2 more
doaj   +1 more source

Aztreonam: clinical and pharmacological characteristics at the present stage [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
One of the urgent problems of modern health care is the growing resistance of microorganisms to antibiotics, including carbapenems, which until recently were considered as the drugs of choice in the treatment of life-threatening infections.
Popov D.A., Zubareva N.A., Parshakov A.A.   +2 more
doaj   +1 more source

Aztreonam

Medical Clinics of North America, 1995
Aztreonam is a monocyclic beta-lactam antibiotic that is active exclusively against the aerobic gram-negative bacilli. It is not ototoxic or nephrotoxic and so is used as an alternative to aminoglycosides in a variety of clinical situations.
D H, Johnson, B A, Cunha
openaire   +2 more sources

Direct Detection of Extended Spectrum β-Lactamases from Positive Blood Cultures by using Aztreonam and Clavulanate [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Bacterial Sepsis by Multidrug Resistant Gram Negative Bacilli (MDRGNB) producing Extended Spectrum β-Lactamases (ESBL) is one of the major causes of mortality and morbidity in hospitals.
Renji Francis, Ambica Rangaiah, Kusuma Gowdra Rangappa, Shwetha Jinnahalli Venugopal   +3 more
doaj   +1 more source