Insight into the Interaction Mechanism of HSA with Aztreonam: A Multispectroscopic and Computational Approach [PDF]
Molecules, 2022 Aztreonam is a Gram-negative bacteria-targeting synthetic monobactam antibiotic. Human serum albumin (HSA) plays an important role in the transference of pharmaceuticals, hormones, and fatty acids, along with other compounds, determining their ...
Altaf Khan, Khan Altaf
exaly +4 more sources
In Vitro Susceptibility of Aztreonam-Vaborbactam, Aztreonam-Relebactam and Aztreonam-Avibactam Associations against Metallo-β-Lactamase-Producing Gram-Negative Bacteria [PDF]
Antibiotics, 2023 Background: Despite the availability of new options (ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam and cefiderocol), it is still very difficult to treat infections caused by metallo-β-lactamase (MBLs)-producers resistant to aztreonam.
Cécile Emeraud +2 more
doaj +2 more sources
Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in
mBio, 2017 While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure.
Peter Jorth +13 more
doaj +4 more sources
Antibiotics, 2021 Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and Pseudomonas are increasingly reported worldwide and are usually associated with high mortality rates (>30%).
Stefano Di Bella +2 more
exaly +3 more sources
Comparative analysis of the effects of aztreonam combined with four β-lactamase inhibitors against carbapenem-resistant Enterobacterales [PDF]
Microbiology SpectrumCarbapenem-resistant Enterobacterales (CRE) pose a global public health threat due to multidrug resistance and treatment failure. This study evaluated the effects of aztreonam combined with four β-lactamase inhibitors (avibactam, clavulanic acid ...
Qing Meng +9 more
doaj +2 more sources
Comparative metabolomics reveal key pathways associated with the synergistic activities of aztreonam and clavulanate combination against multidrug-resistant Escherichia coli [PDF]
mSystems, 2023 The use of combination antibiotics has been useful in the treatment of multidrug-resistant bacterial infections. The synergistic effect of amoxicillin/clavulanate and aztreonam combination against Escherichia coli carrying New Delhi metallo-β-lactamase ...
Jiayuan Zhang +6 more
doaj +2 more sources
In vitro activity of aztreonam in combination with relebactam against gram-negative pathogens producing various serine and metallo-β-lactamases [PDF]
Journal of Global Antimicrobial ResistanceObjectives: Infections caused by carbapenemase-producing Gram-negative pathogens have become a significant global public health challenge due to limited treatment options.
Kengo Hayashi +6 more
doaj +2 more sources
Hospital-Associated Antimicrobial Resistant Bacteria on 95 Mobile Phones: An International Metagenomic "Phonome" Analysis. [PDF]
MicrobiologyopenOn average, phones harbored 3.62 of the top 10 killers and 2.49 ESKAPE organisms. In total, 667 VFGs (8621 Hits) and 262 ARGs (2475 Hits) were identified on 95 mobile phones. Mobile phones serve as a platform for horizontal gene transfer and AMR development.
Goldsworthy A +12 more
europepmc +2 more sources
High in vitro activity of aztreonam/avibactam against NDM-producing Enterobacterales with emerging resistance in Escherichia coli in the United States Mid-Atlantic region [PDF]
Microbiology SpectrumNew Delhi metallo-β-lactamase (NDM)-producing Enterobacterales represent a critical antimicrobial resistance threat with limited therapeutic options. Aztreonam/avibactam, which combines the stability of aztreonam against metallo-β-lactamases with the ...
Eetu Eklund +11 more
doaj +2 more sources
High-dose aztreonam potentiates the combined antimicrobial activity of ceftazidime-avibactam against extensively drug-resistant New Delhi metallo-β-lactamase positive Pseudomonas aeruginosa in severe pneumonia treatment: the first global case report [PDF]
Frontiers in Cellular and Infection MicrobiologyExtensively drug-resistant Pseudomonas aeruginosa (XDR-PA) present increasing incidence and limited therapeutic options, emerging as one of the serious public health threats worldwide.
Yifeng Liu +5 more
doaj +2 more sources