Results 11 to 20 of about 25,663 (196)

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

mBio, 2017
While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure.
Peter Jorth, Kathryn McLean, Anina Ratjen, Patrick R. Secor, Gilbert E. Bautista, Sumedha Ravishankar, Amir Rezayat, Jayanthi Garudathri, Joe J. Harrison, Rachel A. Harwood, Kelsi Penewit, Adam Waalkes, Pradeep K. Singh, Stephen J. Salipante   +13 more
doaj   +3 more sources

A Four-Center Study on the Activity of Aztreonam and Aztreonam-Avibactam Combination Against Clinical Isolates of Gram-Negative Bacilli Producing Representatives of Ambler Class A, B, C or D β-Lactamases. [PDF]

APMIS
ABSTRACT We aimed to investigate the activity of aztreonam and aztreonam‐avibactam combination against gram‐negative bacilli producing different types of β‐lactamases. Activity of aztreonam and aztreonam‐avibactam against 166 isolates (33 AmpC‐producing, 33 ESBL‐producing, 66 carbapenemase‐producing Enterobacterales, 34 metallo‐β‐lactamase‐producing P.
Ceviz Gİ, Mirza HC, Güçlü AÜ, Şanlı ÖÖ, Azap ÖK, Sancak B, İştar EH, Başustaoğlu A.   +7 more
europepmc   +2 more sources

In vitro Synergistic and Bactericidal Effects of Aztreonam in Combination with Ceftazidime/ Avibactam, Meropenem/Vaborbactam and Imipenem/Relebactam Against Dual-Carbapenemase-Producing Enterobacterales [PDF]

Infection and Drug Resistance
Ying Fu,1,2 Yufeng Zhu,1,3 Feng Zhao,1,2,4 Bingyan Yao,1,2 Yunsong Yu,5 Jun Zhang,1,2 Qiong Chen6 1Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of ...
Fu Y, Zhu Y, Zhao F, Yao B, Yu Y, Zhang J, Chen Q   +6 more
doaj   +1 more source

Efektivitas dan Keamanan Penggunaan Aztreonam pada Pasien dengan Cystic Fibrosis : Sebuah Kajian Sistematik [PDF]

, 2022
Cystic fibrosis (CF) adalah penyakit resesif autosomal yang ditandai dengan sekresi paru yang kental, infeksi saluran napas kronis dan insufisiensi pankreas. Bakteri patogen utama penyebab CF yaitu Pseudomonas aeruginosa (Pa).
Riadi, Sahrul, Herawati, Fauna
core   +3 more sources

The phenomenon of changing aztreonam susceptibility in Pseudomonas aeruginosa during formation of colistin resistance in vitro [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To describe the phenotypic and genome characteristics of the phenomenon of aztreonam susceptibility changes in a clinical Pseudomonas aeruginosa isolate developing colistin resistance in an evolutionary experiment in vivo.
Bocharova Yu.A., Kuleshov K.V., Chebotar I.V., Mayanskiy N.A.   +3 more
doaj   +1 more source

Antimicrobial therapy of sepsis caused by carbapenem-resistant Klebsiella pneumoniae in patients with hematological malignancies [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2022
Objective. To compare the efficacy of ceftazidime-avibactam and aztreonam combination therapy with “standard” therapy in patients with hematological malignancies and sepsis, caused by carbapenemresistant K. pneumoniae. Materials and Methods.
Barantsevich N.E., Barantsevich E.P.
doaj   +1 more source

Time-Kill Evaluation of Antibiotic Combinations Containing Ceftazidime-Avibactam against Extensively Drug-Resistant Pseudomonas aeruginosa and Their Potential Role against Ceftazidime-Avibactam-Resistant Isolates

Microbiology Spectrum, 2021
Ceftazidime-avibactam (CZA) has emerged as a promising solution to the lack of new antibiotics against Pseudomonas aeruginosa infections. Data from in vitro assays of CZA combinations, however, are scarce. The objective of our study was to perform a time-
María M. Montero, Sandra Domene Ochoa, Carla López-Causapé, Sonia Luque, Luisa Sorlí, Núria Campillo, Inmaculada López Montesinos, Eduardo Padilla, Núria Prim, Ariadna Angulo-Brunet, Santiago Grau, Antonio Oliver, Juan P. Horcajada   +12 more
doaj   +1 more source

Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales

Frontiers in Medicine, 2023
Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of ...
Yanis Merad, Anne Conrad, Anne Conrad, Anne Conrad, Anne Conrad, Sophie Brosset, Sophie Brosset, Axel Schmidt, Axel Schmidt, Camille Hanriat, Camille Hanriat, Sebastien Lustig, Sebastien Lustig, Sebastien Lustig, Frederic Laurent, Frederic Laurent, Frederic Laurent, Frederic Laurent, Camille Kolenda, Camille Kolenda, Camille Kolenda, Camille Kolenda, Tiphaine Roussel-Gaillard, Tiphaine Roussel-Gaillard, Tiphaine Roussel-Gaillard, Cecile Batailler, Cecile Batailler, Cecile Batailler, Tristan Ferry, Tristan Ferry, Tristan Ferry, Tristan Ferry, Lyon BJI Study group   +32 more
doaj   +1 more source

Aztreonam

Urology, 1993
Aztreonam is the first monobactam and is unique among beta-lactam antibiotics for its spectrum of activity that is exclusively active against gram-negative aerobic bacteria. Broad clinical experience with this agent supports its use in the treatment of adults with severe or complicated urologic infections.
openaire   +4 more sources

The Revival of Aztreonam in Combination with Avibactam against Metallo-β-Lactamase-Producing Gram-Negatives: A Systematic Review of In Vitro Studies and Clinical Cases

Antibiotics, 2021
Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and Pseudomonas are increasingly reported worldwide and are usually associated with high mortality rates (>30%).
Carola Mauri, Alberto Enrico Maraolo, Stefano Di Bella, Francesco Luzzaro, Luigi Principe   +4 more
doaj   +1 more source