Results 41 to 50 of about 20,731 (163)
Frontiers in Microbiology, 2018 The enzymes responsible for the synthesis of the peptidoglycan (PG) layer constitute a fundamental target for a large group of antibiotics. The family of β-lactam antibiotics inhibits the DD-transpeptidase (TPase) activity of the penicillin binding ...
Alejandro Montón Silva +6 more
doaj +1 more source
Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.Antimicrobial resistance and biofilm‐specific tolerance of cultivable Pseudomonas, Bacillus, Brevibacillus and Paenibacillus isolated from deep‐sea sediments of a methane‐seep area off the Southern Brazilian coast. These findings underscore the role of deep‐sea environments as potential reservoirs for antimicrobial‐resistant bacteria (ARB) and ...
Amanda Simão Dias +2 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Nacubactam is a β‐lactamase inhibitor. Early‐phase studies with 1000/2000/4000/8000 mg nacubactam monotherapy were not powered to assess proarrhythmic risk. Therefore, this analysis pooled electrocardiogram data from two placebo‐controlled studies to quantify potential effects of nacubactam on cardiac repolarization.
Jun Morita, Sue McKendrick, Yuji Kumagai
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali +3 more
wiley +1 more source
Drug Analytical Research, 2017 Aztreonam is a monocyclic synthetic antimicrobial with bactericidal activity against Gram-negative bacteria, the first agent from the monobactam family to be therapeutically approved.
Andressa Leme Figueiredo +2 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 9, 14 May 2026.Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Diana Rodríguez +4 more
wiley +1 more source
Unresolving Pneumonia in Type 2 Diabetes: Case Report of Polymicrobial Lung Disease
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Polymicrobial pneumonia caused by the simultaneous infection with multiple pathogens is increasingly recognized in individuals with comorbidities such as type 2 diabetes mellitus (T2DM). The immunocompromised state associated with T2DM predisposes patients to both typical and opportunistic infections, including multidrug‐resistant bacteria and
Micheal Collins Segawa
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Septic arthritis caused by Pantoea agglomerans is uncommon in immunocompetent patients. This case emphasizes the importance of considering atypical pathogens in septic arthritis, underscores the role of microbiological confirmation, and highlights the necessity of prompt, targeted antimicrobial therapy to achieve favorable outcomes.
Paul Ngongo Tshonda +7 more
wiley +1 more source
Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales [Corrigendum]
Infection and Drug Resistance, 2021 Tan X, Kim HS, Baugh K, et al. Infect Drug Resist.2021;14:125–142. Page 134, left column, second paragraph, fourth sentence from the bottom, the text “Generally, all four tetracyclines have higher tissue concentrations than ...
Tan X +8 more
doaj
Journal of Biophotonics, Volume 19, Issue 5, May 2026.This randomized pilot study evaluated photodynamic therapy as an adjunctive treatment for diabetic foot ulcers compared with conventional care. The findings demonstrated a greater reduction in lesion area in the intervention group and potential benefits in the microbiological profile of the wounds, suggesting the clinical relevance and therapeutic ...
Maria Girlane Sousa Albuquerque Brandão +6 more
wiley +1 more source