Results 41 to 50 of about 2,475 (111)

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Functional relocation of the maize chloroplast atpB gene to the nucleus restores photosynthetic competence to a gene‐edited non‐photosynthetic mutant

Plant Biotechnology Journal, EarlyView.
Summary With the increasing food demands of a global population projected to reach 9.6 billion by 2050, there is an urgent need to increase crop productivity. Bioengineering approaches to boost crop yields include enhancing photosynthetic capacity, though relatively few efforts focus on C4 crop species despite their significant presence in agriculture.
Venkata RamanaRao Mangu, Kelsey Jenkins, Anna Pratt, Kara A. Boltz, Leila Pazouki, Alice Y. Hui, Muruganantham Mookkan, Jeffrey M. Staub   +7 more
wiley   +1 more source

A Discussion of Histological Technique With Special Reference to Double and Triple Staining [PDF]

, 1944
This 18 page thesis discusses the process of fixing, dehydrating and clearing tissues, as well as the effects of various types of dyes and staining ...
McKinney, Margaret J.
core   +1 more source

Acute introduction of monomeric or multimeric α‐synuclein induces distinct impacts on synaptic vesicle trafficking at lamprey giant synapses

The Journal of Physiology, EarlyView.
Abstract figure legend Monomeric and multimeric α‐synuclein were purified from HEK cells and delivered to lamprey reticulospinal (RS) synapses via axonal microinjection, followed by stimulation (20 Hz, 5 min). Ultrastructural analysis showed that both α‐synuclein species impaired intracellular vesicle trafficking, leading to synaptic vesicle loss and ...
Cristina Román‐Vendrell, Jaqulin N. Wallace, Aurelia Hays Watson, Meral Celikag, Tim Bartels, Jennifer R. Morgan   +5 more
wiley   +1 more source

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Inhibition Peroxiredoxin‐2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS‐Mediated Apoptosis in Fibroblast‐Like Synoviocytes

MedComm, Volume 6, Issue 6, June 2025.
Capsaicin attenuating arthritis by inhibiting AKT phosphorylation and activating the NRF2–HO‐1 axis via targeting PRDX2 ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage.
Hengkai He, Mingjing Hao, Piao Luo, Junhui Chen, Yehai An, Jingnan Huang, Ruiyi He, Qingfeng Du, Qian Zhang, Jigang Wang   +9 more
wiley   +1 more source

Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries

Smart Medicine, Volume 4, Issue 2, June 2025.
High uric acid‐induced vascular injuries are always accompanied with hyperuricemia, for which seeking for effective safety drugs is an urgent and crucial problem that needs to be solved. Here, we have successfully screened isoliquiritigenin out from multiplex traditional Chinese medicine monomers in promoting the repair of high uric acid‐induced ...
Hongyan Zhou, Xinyu Song, Yingying Tian, Lili Zhao, Jingyi Yang, Fangfu Ye, Ting Cao, Jiayu Zhang   +7 more
wiley   +1 more source

Protozoan Co‐Infection Drives Fish Mortality Event in Crete's Karteros River

Journal of Fish Diseases, Volume 48, Issue 6, June 2025.
ABSTRACT In August 2024, a significant fish kill involving hundreds of flathead grey mullet (Mugil cephalus) was reported in the delta region of the Karteros River, Crete, Greece. The investigation identified the primary cause of mortality as severe parasitic infections, specifically from the protozoan parasites Amyloodinium ocellatum and Trichodina sp.
Pantelis Katharios, Evangelia Karageorgou   +1 more
wiley   +1 more source

Histone Deacetylase 6 Controls Atrial Fibrosis and Remodeling in Postinfarction Mice Through the Modulation of Wnt3a/GSK‐3β Signaling

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Elevated levels of HDAC6 activate the Wnt3a/GSK3β signaling pathway, leading to the phosphorylation of GSK3β and its subsequent binding to HDAC6, followed by translocation into the mitochondria. Within the mitochondria, GSK3β interacts with TFAM, competitively reducing TFAM's binding to mtDNA. This reduction decreases mtDNA transcription and stability,
Shangzhi Shu, Junqiao Fang, Longguo Zhao, Jiatong Han, Meiping Zhang, Chaoqun Huang, Xian Wu Cheng, Shuyan Li   +7 more
wiley   +1 more source

A case of argyria as consequence of alternative medical treatment

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Murat Cavdar, Damian Kostner, Mathias Drach, Veronique Touzeau‐Römer, Katharina Grabmeier‐Pfistershammer, Johanna Strobl   +5 more
wiley   +1 more source