Azurin a potent anticancer and antimicrobial agent isolated from a novel Pseudomonas aeruginosa strain [PDF]
Scientific ReportsAzurin, a bacterial blue-copper protein, has garnered significant attention as a potential anticancer drug in recent years. Among twenty Pseudomonas aeruginosa isolates, we identified one isolate that demonstrated potent and remarkable azurin synthesis ...
Yasser Elbahloul
exaly +3 more sources
Computational Modeling, High-Level Soluble Expression and In Vitro Cytotoxicity Assessment of Recombinant Pseudomonas aeruginosa Azurin: A Promising Anti-Cancer Therapeutic Candidate [PDF]
Pharmaceutics, 2023 Azurin is a natural protein produced by Pseudomonas aeruginosa that exhibits potential anti-tumor, anti-HIV, and anti-parasitic properties. The current study aimed to investigate the potential of azurin protein against breast cancer using both in silico ...
Shakira Aslam +9 more
doaj +2 more sources
Efficient Cytotoxicity of Recombinant Azurin in Escherichia coli Nissle 1917-Derived Minicells against Colon Cancer Cells [PDF]
Bioengineering, 2023 Compared to chemical drugs, therapeutic proteins exhibit higher specificity and activity and are generally well-tolerated by the human body. However, the limitations, such as poor stability both in vivo and in vitro as well as difficulties in penetrating
Yi Ma +5 more
doaj +2 more sources
The Influence of pH on Long-Range Electron Transfer and Proton-Coupled Electron Transfer in Ruthenium-Modified Azurin [PDF]
MoleculesLong-range electron transfer (ET) is an essential component of all biological systems. Reactions of metalloproteins are important in this context.
Nikta Ghazi, Jeffrey J. Warren
doaj +2 more sources
Suppression of mitochondrial energy production by a photosynthetic bacterial cupredoxin peptide inhibits tumor growth [PDF]
Signal Transduction and Targeted TherapyAccumulating evidence shows that bacteria influence cancer homeostasis, yet the effects of tumor‑associated microbes and their products remain largely unexplored. We previously reported that P.
Samer A. Naffouje +11 more
doaj +2 more sources
Cold-Azurin, a New Antibiofilm Protein Produced by the Antarctic Marine Bacterium Pseudomonas sp. TAE6080 [PDF]
Marine DrugsBiofilm is accountable for nosocomial infections and chronic illness, making it a serious economic and public health problem. Staphylococcus epidermidis, thanks to its ability to form biofilm and colonize biomaterials, represents the most frequent ...
Caterina D’Angelo +7 more
doaj +2 more sources
Anticancer peptides as novel immunomodulatory therapeutic candidates for cancer treatment [PDF]
Exploration of Targeted Anti-tumor TherapyCancer remains a concern after years of research in this field. Conventional therapies such as chemotherapy, radiation, and surgery are available for cancer treatment, but they are characterized by various side effects.
Apurva Sood +3 more
doaj +2 more sources
Methanol‐Free Protein Expression in Komagataella phaffii With Magnetic or Non‐Magnetic Heating [PDF]
Microbial BiotechnologyKomagataella phaffii is among the most widely used expression systems, with methanol‐inducible promoters being preferred for protein expression due to their stringent regulation and exceptional strength.
Ibrahim Dagci +5 more
doaj +2 more sources
An Investigation of the Influence of Tyrosine Local Interactions on Electron Hopping in a Model Protein [PDF]
MoleculesMulti-step electron transfer reactions are important to the function of many cellular systems. The ways in which such systems have evolved to direct electrons along specific pathways are largely understood, but less so are the ways in which the reduction–
Curtis A. Gibbs +3 more
doaj +2 more sources
In vitro and in vivo antitumor activity of Laz-expressing Salmonella Typhimurium YB1 via optimized secretion and regulation [PDF]
AMB ExpressSalmonella enterica serovar Typhimurium strain YB1 is a genetically engineered obligate anaerobe with strong tumor-targeting potential. In this study, we evaluated YB1 as a delivery platform for Laz, a lipidated azurin-derived protein, using three ...
Yahia I. Abouelenen +5 more
doaj +2 more sources