Results 61 to 70 of about 780 (156)

Antiviral Drugs and Their Roles in the Treatment of Coronavirus Infection [PDF]

, 2022
Viruses are the major pathogenic agents that cause various diseases. Antiviral drugs are used for the treatment of viral infections. Emergent advances of antiviral drugs are focused on two different approaches: targeting the host cell factors or the ...
Alghamdi, Saad, Alsafi, Radi, Asif, Mohammad   +2 more
core   +2 more sources

Breakthrough of glycobiology in the 21st century [PDF]

, 2023
As modern medicine began to emerge at the turn of the 20th century, glycan-based therapies advanced. DNA- and protein-centered therapies became widely available. The research and development of structurally defined carbohydrates have led to new tools and
Cuihong Tian, Cuihong Tian, Cuihong Tian, Gehendra Mahara, Gehendra Mahara, Jinxiu Zhu, Jinxiu Zhu, Xiaojia Xu, Xiaojia Xu, Xiaojia Xu   +9 more
core   +1 more source

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

Is Azvudine Comparable to Nirmatrelvir-Ritonavir in Real-World Efficacy and Safety for Hospitalized Patients with COVID-19? A Retrospective Cohort Study

Infectious Diseases and Therapy, 2023
Introduction Azvudine and nirmatrelvir-ritonavir are more extensively used to treat COVID-19 in China due to their earlier approval by the National Medical Products Administration.
Qinqin Zhao, Bei Zheng, Bing Han, Pinpin Feng, Zhongni Xia, Hong Jiang, Yin Ying, Jun Zhu, Cheng Fei, Junlei Xiang, Lingli Shen, Qiliang Luo, Yinhuan Wu, Ayiguzhali Wusiman, Chuanwei Xin, Meiling Zhang, Gonghua Li, Xiang Li   +17 more
doaj   +1 more source

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor

MedComm, Volume 6, Issue 9, September 2025.
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang, Huiqiang Wang, Shuo Wu, Ge Yang, Haiyan Yan, Lijun Qiao, Xingqiong Li, Mengyuan Wu, Jiandong Jiang, Yuhuan Li   +9 more
wiley   +1 more source

The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19 [PDF]

, 2023
To effectively respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an increasing number of researchers are focusing on the antiviral activity of cepharanthine (CEP), which is a clinically approved drug being used for over 70 years ...
Binbin Xia, Hua Cheng, Jiaxin Li, Jing Chen, Jingyao Pang, Li Zheng, Liushui Li, Wenfang Sun, Yali Li, Yang Liu   +9 more
core   +1 more source

Real-world efficacy of oral azvudine in hospitalized patients with COVID-19: A multicenter retrospective cohort study

Journal of Infection and Public Health
Background: Azvudine has become a widely used treatment for COVID-19 in China. Our study aimed to assess the real-world efficacy of azvudine in hospitalized COVID-19 patients during the omicron variant surge.
Rui Han, Youhong Guan, Pulin Li, Min Tang, Guanghe Fei, Daxiong Zeng, Ran Wang   +6 more
doaj   +1 more source

Treatment of Coronavirus Disease 2019: Shooting in the Dark [PDF]

, 2020
The identification of effective interventions against the coronavirus disease 2019 (COVID-19) pandemic has become a health priority. The rational treatment of a disease is based on the knowledge of its pathophysiology, the identification of a therapeutic
Juan Tamargo
core   +1 more source

Drug treatments for covid-19: living systematic review and network meta-analysis [PDF]

, 2021
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19). Design Living systematic review and network meta-analysis. Data sources
Agarwal A, Agoritsas T, Bartoszko JJ, Brignardello-Petersen R, Chu DK, Couban R, Cusano E, Darzi A, Devji T, Fang B, Fang C, Flottorp SA, Foroutan F, Ge L, Ghadimi M, Guyatt GH, Han MA, Heels-Ansdell D, Honarmand K, Hou L, Hou X, Ibrahim Q, Izcovich A, Khamis A, Kum E, Lam B, Lamontagne F, Liu Q, Loeb M, Marcucci M, Martinez JPD, McLeod SL, Motaghi S, Murthy S, Mustafa RA, Neary JD, Pardo-Hernandez H, Qasim A, Rada G, Riaz IB, Rochwerg B, Sadeghirad B, Sekercioglu N, Sheng L, Siemieniuk RAC, Sreekanta A, Switzer C, Tendal B, Thabane L, Tomlinson G, Turner T, Vandvik PO, Vernooij RWM, Viteri-García A, Wang Y, Yao L, Ye Z, Zeraatkar D   +57 more
core   +1 more source

SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice [PDF]

, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved to variants associated with milder disease. We employed the k18-hACE2 mouse model to study how differences in the course of infection by SARS-CoV-2 variants alpha, delta, and ...
Alves, Nuno L, Costa, Jose Maria, Couto, Joana, Fernandes, Ana Isabel, Ferreirinha, Pedro, Goncalves, Rute, Lamas, Sofia, Madureira, Pedro, Saraiva, Margarida, Silva, Marta L, Silverio, Diogo   +10 more
core