Results 101 to 110 of about 29,791 (216)

Factors influencing the expression of bacterial B-glucuronidase activities

Gastroenterology, 2000
Joseph W. Leung, Yan-lei Liu
openaire   +1 more source

Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics

Cell Host & Microbe
Hormones and neurotransmitters are essential to homeostasis, and their disruptions are connected to diseases ranging from cancer to anxiety. The differential reactivation of endobiotic glucuronides by gut microbial β-glucuronidase (GUS) enzymes may influence interindividual differences in the onset and treatment of disease.
Simpson, J.B., Walker, M.E., Sekela, J.J., Ivey, S.M., Jariwala, P.B., Storch, C.M., Kowalewski, M.E., Graboski, A.L., Lietzan, A.D., Walton, W.G., Davis, K.A., Cloer, E.W., Borlandelli, V.B., Hsiao, Y.-C., Roberts, L.R., Perlman, D.H., Liang, X., Overkleeft, H.S., Bhatt, A.P., Lu, K., Redinbo, M.R.   +20 more
openaire   +3 more sources

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, Volume 110, Issue 1, Page 125-130, July 2026.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Interaction Between Rec8 and Mis4 Is Required for Axis‐Loop Chromatin Formation and Homologous Chromosome Recombination During Meiosis

Genes to Cells, Volume 31, Issue 4, July 2026.
We identified a Mis4 cohesin loader mutant that is specifically defective in chromatin axis formation and homologous recombination while retaining normal sister chromatid cohesion. The mis4‐LR mutant, carrying the L1150S and R1159G amino acid substitutions, exhibited reduced interaction between Mis4 and Rec8, suggesting a meiosis‐specific role for the ...
Takeshi Sakuno, Yasuto Murayama, Tokuko Haraguchi, Yasushi Hiraoka   +3 more
wiley   +1 more source

The vesicle trafficking R‐SNARE VAMP714 connects auxin responses, ROS and ion homeostasis in Arabidopsis under salt stress

New Phytologist, Volume 251, Issue 1, Page 207-227, July 2026.
Network of VAMP714‐dependent interactions during salt stress. Summary Plant responses to salt stress include an altered root architecture mediated by ion imbalances, reactive oxygen species (ROS) accumulation, and altered hormonal responses. Auxin is implicated in these processes.
Jialei Sun, Julien Agneessens, Jennifer F. Topping, Keith Lindsey   +3 more
wiley   +1 more source

COCHLEATA controls spatial regulation of cytokinin and auxin during nodule development

New Phytologist, Volume 251, Issue 1, Page 228-244, July 2026.
Nodule development defects in the coch mutant include root‐like structures, reduced colonisation, and vascular disorganisation. Summary Root nodules host nitrogen‐fixing bacteria and likely evolved through modifications of the lateral root program. Members of the NOOT‐BOP‐COCH‐LIKE transcriptional coregulator family suppress root identity in nodules ...
Karen Velandia, Muhammad Nouman Sohail, Tiana E. Scott, Alejandro Correa‐Lozano, Alannah Mannix, Eloise Foo   +5 more
wiley   +1 more source

The Transcription Factor OsWRKY64 Interacts With OsART1 to Positively Regulate Al Resistance in Rice

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4656-4671, July 2026.
A proposed working model illustrating the cooperative regulation of Al tolerance by OsWRKY64 and OsART1 in rice. Under Al stress conditions in acidic soil, the transcription factor OsART1 directly binds to the promoter of OsWRKY64 to activate its transcription. The synthesized OsWRKY64 protein then physically interacts with OsART1 in the nucleus.
Changzhao Chen, Qiang Zhang, Yonggang Xu, Jibo Yang, Jing Yan, Mengmeng Jiang, Lu Zheng, Tingwu Liu, Jiu Huang, Renfang Shen, Xiaofang Zhu   +10 more
wiley   +1 more source

High-throughput identification of bacterial β-glucuronidase inhibitors using machine learning. [PDF]

Gut Microbes
Zhang B, Yue H, Skalse A, Sangfuang N, Shorthouse D, Gaisford S, Basit AW.   +6 more
europepmc   +1 more source

How Polyphenol Metabolites Spatiotemporally Reprogram Transcription Factors and Human Proteostasis: A Metabolite-Centric Framework. [PDF]

Curr Issues Mol Biol
Lastra JMP, Andrés CMC, Munguira EB, Juan CA, Pérez Lebeña E.   +4 more
europepmc   +1 more source