Results 91 to 100 of about 13,971,057 (260)

Pathogenesis-based treatments in primary Sjogren's syndrome using artificial intelligence and advanced machine learning techniques: a systematic literature review

Human Vaccines & Immunotherapeutics, 2018
Big data analysis has become a common way to extract information from complex and large datasets among most scientific domains. This approach is now used to study large cohorts of patients in medicine. This work is a review of publications that have used
Nathan Foulquier, Pascal Redou, Christophe Le Gal, Bénédicte Rouvière, Jacques-Olivier Pers, Alain Saraux   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Age-related changes of apoptotic cell death in human lymphocytes [PDF]

, 2006
Apoptosis seems to be involved in immunosenescence associated with aging. Moreover, in lymphocytes (PBL) of patients with Alzheimer's disease, an increased susceptibility to the apoptotic pathway has been described possibly due to impaired protection of ...
Schindowski, Katharina, Leutner, Silke, Eckert, Anne, Müller, Walter E.   +3 more
core  

Splenic marginal zone B lymphocytes decreased in post-transplant APRIL/BLyS blockade compared to transplant control.

, 2019
Flow cytometry was used to assess MZ B lymphocytes for each group. (A) Each graph shows number of cells per 100,000 lymphocytes. MZ B lymphocytes were defined as HIS57+CD45RA+. (B) Representative flow cytometry data of spleen MZ B lymphocytes.
Natalie M. Bath (6316517), Arjang Djamali (6316535), Brittney A. Boldt (6316523), Sarah E. Panzer (6316532), Robert R. Redfield III (6316538), Xiang Ding (607469), Adarsh Sukhwal (6316526), Shannon R. Reese (6316529), Nancy A. Wilson (36137), Bret M. Verhoven (6316520)   +9 more
core   +1 more source

Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE, RODNEY E. PHILLIPS, Phillips, R.E., SIOBHAN CROWLEY, Edwards, A., McIntyre, K., MIKE BUNCE, Morgan, B., McMichael, A.J., BARBARA MORGAN, ANNE EDWARDS, PETER KRAUSA, Crowley, S., Krausa, P., Goulder, P.J.R., PAUL GIANGRANDE, ANDREW J. McMICHAEL, Giangrande, P., PHILIP J.R. GOULDER, Bunce, M.   +19 more
core   +1 more source

B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection

, 2022
S.1215-1229Antibody-mediated immunity to Shigella, the causative agent of bacillary dysentery, requires several episodes of infection to get primed and is short-lasting, suggesting that the B cell response is functionally impaired.
Mozeleski, B., Parsot, C., Arena, E.T., Nothelfer, K., Neunlist, M., Dinadayala, P., Burger-Kentischer, A., Belotserkovsky, I., Phalipon, A., Pinaud, L., Sansonetti, P.J., Raqib, R.   +11 more
core   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

CCR3 and CCR10 mean fluorescence intensity on CD19+ B lymphocytes.

, 2013
Median fluorescence intensity (MFI). Panel A: CCR3+/CCD19+ B lymphocytes; panel B: CCR10+/CCD19+ B lymphocytes. Median values, standard deviations, and statistically significant differences are indicated. Thirty-nine HIV-exposed seronegative individuals (
Sergio Lo Caputo (34832), Daria Trabattoni (34837), Manuela Nebuloni (34846), Francesco Mazzotta (34847), Mario Clerici (34848), Louise Kuhn (34833), Johanna Gajardo (34835), Manuela Borelli (34834), Dorothy H. Bray (34842), Francisco Veas (34845), Grace M. Aldrovandi (34843), Eleonora Castelletti (34831), Donald M. Thea (34844), Alberto Clivio (34840), Eleonora Lauri (34839), Moses Sinkala (34836), Chipepo Kankasa (34838), Luca Piacentini (34841)   +17 more
core   +1 more source

B-lymphocytes in the Pathophysiology of Pancreatic Adenocarcinoma

, 2022
Pancreatic adenocarcinoma is highly infiltrated by B lymphocytes but the relevance of these immune cells in tumor development has been surprisingly overlooked until recently.
Della Torre E, Testoni S, Minici C, Minici C., Testoni S., Della-Torre E.   +5 more
core   +1 more source

Clinical observation of monoclonal fibrillary glomerulonephritis

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Monoclonal gammopathy of renal significance is a condition caused by the proliferation of a clone of B-lymphocytes or plasma cells that does not reach the criteria required for the initiation of treatment for oncohematological indications, but is ...
T. A. Garkusha, F. V. Alyab'ev, T. A. Vdovik   +2 more
doaj   +1 more source