Results 71 to 80 of about 13,971,057 (260)

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Non-switched B lymphocytes significantly reduced with APRIL/BLyS blockade.

, 2019
Flow cytometry was used to assess mature B lymphocyte populations for each group. Each graph shows number of cells per 100,000 lymphocytes. (A) Non-switched B lymphocytes were defined as IgD+CD45R+CD27+.
Natalie M. Bath (6316517), Arjang Djamali (6316535), Brittney A. Boldt (6316523), Sarah E. Panzer (6316532), Robert R. Redfield III (6316538), Xiang Ding (607469), Adarsh Sukhwal (6316526), Shannon R. Reese (6316529), Nancy A. Wilson (36137), Bret M. Verhoven (6316520)   +9 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Discrimination of human cytotoxic lymphocytes from regulatory and B-lymphocytes by orthogonal light scattering [PDF]

, 1986
Light scattering properties of human lymphocyte subpopulations selected by immunofluorescence were studied with a flow cytometer. Regulatory and B-lymphocytes showed a low orthogonal light scatter signal, whereas cytotoxic lymphocytes identified with leu-
van Berkel, W., de Grooth, B.G., ten Napel, C.H.H., Greve, J., Terstappen, L.W.M.M.   +4 more
core   +1 more source

Longitudinal humoral and memory B-cell responses to repeated SARS-CoV-2 vaccination in long-term care facilities residents

Immunity & Ageing
Background Long-term care facility (LTCF) residents represent one of the populations most vulnerable to SARS-CoV-2 infection and have experienced repeated vaccination and natural viral exposure since the beginning of the COVID-19 pandemic.
Annapina Palmieri, Cecilia Damiano, Pasqualina Leone, Chiara Sugoni, Christian Albano, Eva Piano Mortari, Ilaria Schiavoni, Caterina Trevisan, Alba Malara, Alberto Zucchelli, Raffaele Antonelli Incalzi, Rosa Prato, Francesca Fortunato, Tatjana Baldovin, Alessandra Coin, Pasquale Minchella, Stefania Giordano, Anna Teresa Palamara, Rita Carsetti, Graziano Onder, Giorgio Fedele   +20 more
doaj   +1 more source

3D printing in rheumatology

EULAR Rheumatology Open
: Three-dimensional (3D) printing, or additive manufacturing, revolutionises medicine by creating customised objects from digital models, layer by layer.
Samuel Guigo, Sophie Débonnaire, Zoé Rapin, Alain Saraux   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Review on radiomic analysis in 18F-fluorodeoxyglucose positron emission tomography for prediction of melanoma outcomes

Cancer Imaging
Over the past decade, several strategies have revolutionized the clinical management of patients with cutaneous melanoma (CM), including immunotherapy and targeted tyrosine kinase inhibitor (TKI)-based therapies.
Karim Amrane, Coline Le Meur, Philippe Thuillier, Christian Berthou, Arnaud Uguen, Désirée Deandreis, David Bourhis, Vincent Bourbonne, Ronan Abgral   +8 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source