Results 271 to 280 of about 779,870 (354)

The multifaceted roles of B lymphocytes in metabolic dysfunction-associated steatotic liver disease. [PDF]

Front Immunol
Li H, Xia N.
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Subpopulation dynamics of T and B lymphocytes in Sjögren's syndrome: implications for disease activity and treatment. [PDF]

Front Immunol
Meng Q, Ma J, Cui J, Gu Y, Shan Y.
europepmc   +1 more source

The targeting of human and mouse B lymphocytes by dasatinib

, 2015
Morten P. Oksvold, Johanna M. Duyvestyn, Samantha A. Dagger, Samuel J. Taylor, Lise Forfang, June H. Myklebust, Erlend B. Smeland, Wallace Y. Langdon   +7 more
openalex   +2 more sources

Serial monitoring of immunologic function and phenotype of lymphocytes in the blood of transplanted patients randomized to cyclosporine or FK 506 [PDF]

, 1991
Abu-Elmagd, K, Alessiani, M, Bryant, J, Fung, J, Herberman, RB, Jain, A, Starzl, TE, Whiteside, TL, Wilson, J, Zeevi, A   +9 more
core  

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Citrullinated Autoantigen-Specific T and B Lymphocytes in Rheumatoid Arthritis: Focus on Follicular T Helper Cells and Expansion by Coculture. [PDF]

ACR Open Rheumatol
Ammon T, Zeiträg J, Mayr V, Benedicic M, Holthoff HP, Ungerer M.   +5 more
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma. [PDF]

Front Immunol
Fang J, Yu S, Wang W, Liu C, Lv X, Jin J, Han X, Zhou F, Wang Y.   +8 more
europepmc   +1 more source

Maturation finale des lymphocytes B : de la commutation de classe aux conséquences pathologiques de la production d'immunoglobulines anormales

, 2015
Amélie Bonaud
openalex   +1 more source