Results 331 to 340 of about 14,042,312 (388)

Nanoneedle‐Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T‐Cells

Advanced Science, EarlyView.
Low reproducibility and inefficient gene transfer hamper clinical manufacturing of chimeric antigen receptor regulatory T cells (CAR Tregs). Nanoneedle mediated electroporation generates primary human CAR Tregs under good manufacturing practice conditions with superior efficiency compared to viral transduction.
Ningjia Sun, Cong Wang, William Edwards, Yikai Wang, Xiangrong L. Lu, Chenlei Gu, Samuel McLennan, Panicos Shangaris, Peng Qi, Daniela Mastronicola, Cristiano Scottà, Giovanna Lombardi, Ciro Chiappini   +12 more
wiley   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Immuno-Diagnostic Interest in Monitoring CD16+CD56+ (Natural Killer) Cells and CD19+CD45+ (B Lymphocytes) in Individuals Newly Diagnosed with HIV in a Tertiary Care Center. [PDF]

J Clin Med
Al-Mughales J.
europepmc   +1 more source

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B Lymphocytes and the Skeleton

Annals of the New York Academy of Sciences, 2007
Abstract:  Mesenchymal lineage cells arise from pluripotent stem cells in the bone marrow (BM) and transition through a series of developmental stages resulting in mature functional cells. This specification results in the development of osteoblast, adipocytes, myoblasts, chondroblasts, and stromal cells (part of the recticular network).
Joseph A. Lorenzo, Mark C. Horowitz
openaire   +3 more sources

T and B lymphocytes in vitiligo

Archives of Dermatological Research, 1978
Lymphocyte subpopulations were studied in 38 patients with vitiligo and in 44 controls. No significant differences in the results of several immunological examinations (E-RFC, EAC-RFC, EA-RFC, IF, IF-elution) came to light results suggest that the lymphocytes are probably not implied in the pathogenesisof vitiligo.
Anna Alario, Jean Paul Ortonne
openaire   +3 more sources

Suppressor B lymphocytes

Immunology Today, 1983
B cells can influence an immune response in an antigen-specific manner by generating antibody which shuts down the response through negativefeedback. But there is growing evidence that B cells can also act upon antibody production as non-specific suppressor cells.
Michael K. Hoffmann, Kathleen M Gilbert
openaire   +3 more sources

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.

International Immunology, 1996
A mAb J43 has been produced against the product of the mouse PD-1 gene, a member of the Ig gene superfamily, which was previously isolated from an apoptosis-induced T cell hybridoma (2B4.11) by using subtractive hybridization.
Y. Agata, A. Kawasaki, H. Nishimura, Y. Ishida, T. Tsubata, H. Yagita, T. Honjo   +6 more
semanticscholar   +1 more source

B-lymphocyte subpopulations

Immunology Today, 1983
B lymphocytes are exceptionally diverse, partly because different clones have membrane receptors with specificities for different antigens and partly because the cells exist in a series of distinct differentiation states and may constitute more than a single cellular lineage.
William E. Paul, John T. Kung
openaire   +2 more sources

Trafficking of Adoptively Transferred B Lymphocytes in B-Lymphocyte-Deficient Mice [PDF]

Journal of Experimental Biology, 1997
ABSTRACT Many studies have investigated the fate of adoptively transferred lymphocytes in recipient mice, although little is known of the sites where these transferred cells reside at particular time points. Using flow cytometry, we analyzed the trafficking pattern of adoptively transferred naive B cells into the lymphoid organs of ...
Mark J. Mamula, Rita Roth
openaire   +2 more sources

T and B lymphocyte subpopulations

Pediatrics, 1975
The two major subpopulations of lymphocytes, T cells (thymus-dependent lymphocytes) and B cells (bursal equivalent or thymus-independent lymphocytes) have multiple roles in the immune system. In general, T cells are the functioning cells in the cellular immune system (delayed hypersensitivity, graft rejection, graft-versus hostreaction); and B cells ...
R C, Seeger, E R, Stiehm
openaire   +2 more sources