Results 41 to 50 of about 13,971,057 (260)

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
Wagner, Thomas, Reynders, Veerle, Veerle Reynders, Stefan Loitsch, Joachim Bargon, Reynders Veerle, Thomas Wagner, Steinhauer, Constanze, Bargon Joachim, Steinhilber Dieter, Bargon, Joachim, Loitsch Stefan, Dieter Steinhilber, Constanze Steinhauer, Loitsch, Stefan Marcel, Wagner Thomas, Steinhauer Constanze, Steinhilber, Dieter   +17 more
core   +2 more sources

Early-stage and mature B lymphocytes significantly decreased but long-lived B lymphocytes increased in APRIL^-/-/BLyS^-/- group.

, 2022
Flow cytometry was used to assess B lymphocytes for each transplant group. Each graph shows number of cells per 100,000 lymphocytes. A-/-/B-/-, APRIL-/-/BLyS-/-. Data analyzed using ANOVA.
Natalie M. Bath (6316517), Arjang Djamali (6316535), Weifeng Zeng (10666122), Weixiong Zhong (290257), Robert R. Redfield III (6316538), Lauren Coons (7541756), Bret M. Verhoven (6316520), Nancy A. Wilson (7541753)   +7 more
core   +1 more source

Lymphocytes [PDF]

, 2019
Lymphocytes have been the main research object of the medic and toxicological sciences for the last six decades. In addition to important roles, they ply m the immune system, lymphocytes have been the primary test material often employed m pure research ...
İla, Hasan Basri
core   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

On adaptor proteins shaping Ca2+ signals in activated B lymphocytes [PDF]

, 2008
Neumann K. On adaptor proteins shaping Ca2+ signals in activated B lymphocytes. Bielefeld (Germany): Bielefeld University; 2008.Signale des B-Zell-Antigenrezeptors (BZR) regeln sowohl die Aktivierung pathogenspezifischer B-Lymphozyten als auch die ...
Neumann, Konstantin
core  

microRNAs in the control of lymphocytes response [PDF]

, 2009
Recently, it has become evident the importance of miRNAs in regulating immune response, as well as immune cell development. During my phD fellow I focused my attention on the relationship B-lymphocytes-microRNA; in particular I examined two the different
Rossi, Annalisa
core   +1 more source

T and B cell responses in different immunization scenarios for COVID-19: a narrative review

Frontiers in Immunology
Vaccines against COVID-19 have high efficacy and low rates of adverse events. However, none of the available vaccines provide sterilizing immunity, and reinfections remain possible.
Eva Piano Mortari, Francesca Ferrucci, Irini Zografaki, Rita Carsetti, Luciano Pacelli   +4 more
doaj   +1 more source

Study of the IL-4 and IL-4δ2 interaction with the IL-4R receptors of the I and II types in silico and the effect on the functional activity of mononuclear cells in vitro

Бюллетень сибирской медицины, 2010
Alternatively spliced interleukins are very actively studied over the last years. Splice form of IL-4 — IL-4δ2 has antagonistic effects to its full form on proliferative activity of human mononuclear blood cells and their IL-6 production.
K. V. Goremykin, A. N. Silkov, B. V. Shilov, V. Yu. Serebrov, A. E. Sazonov, S. V. Sennikov   +5 more
doaj   +1 more source

Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases

Case Reports in Nephrology and Dialysis, 2022
Studies investigating the effect of rituximab in children with nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS) have reported conflicting results, with some concluding that patients may require additional immunosuppressive therapy
Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza   +2 more
doaj   +1 more source