Results 41 to 50 of about 696,018 (262)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Number of T- and B-lymphocytes and their functional activity in the blood of common carps aff ected by Aeromonosis, and in the treatment of probiotic Enteronormin

Науковий вісник ветеринарної медицини, 2020
Fish bacterial infectious diseases are a signifi cant problem for aquaculture, often leading to massive fi sh deaths and signifi cant economic losses. For fi sh treatment often used antibacterial drugs: nitrofuran, antibiotics, feed antibiotics, as well ...
Solopova Kh., Vishchur O.
doaj   +1 more source

REGULATION OF PERIPHERAL B-LYMPHOCYTE DIFFERENTIATION IN RECURRENT MISCARRIAGE

Медицинская иммунология, 2021
The important role of immune disorders in recurrent miscarriage has been proven. Clarification of the character of B-lymphocyte differentiation and its regulation factors in women with threatened miscarriage and recurrent miscarriage in history is an ...
A. I. Malyshkina, N. Yu. Sotnikova, A. V. Kust, D. N. Voronin   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Influence of Bacillus anthracis 34F₂ Sterne Antigen Preparations in Combination with Cobaltarabinogalactan on the Subpopulation Structure of B-lymphocytes (Communication 2)

Эпидемиология и вакцинопрофилактика, 2015
Study of Bacillus anthracis 34F2 Sterne antigenic preparation S-2 and its combined use with nanostructured cobalt-arabinogalaktan (Со-АG) is presented. The ability of these preparations to stimulate proliferation and differentiation of B-lymphocytes is ...
V. V. Voytkova, V. I. Dubrovina, S. V. Lukyanov, O. V. Yuryeva, O. B. Kol’Esnikova, K. M. Korytov, G. P. Aleksandrova, V. P. Iljin, S. V. Balakhonov   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Experience of Using Rituximab in a Girl with Severe Systemic Lupus Erythematosus

Педиатрическая фармакология, 2015
Heavy complications of systemic lupus erythematosus, such as the anti-phospholipin syndrome, generalized vaskulit and severe defeats of the central nervous system continue to remain relevant.
A. A. Lebedenko, A. M. Sarychev, A. V. Kharlamova, E. V. Nosova, E. A. Tarasova, K. V. Grin’ko   +5 more
doaj   +1 more source

CD5-Positive B Lymphocytes after Kidney Transplantation

Diagnostics, 2021
Kidney transplantation is the treatment of choice for end-stage kidney diseases. Unfortunately, kidney allograft recipients rarely develop tolerance or accommodation and require life-long immunosuppression.
Maciej Zieliński, Agnieszka Tarasewicz, Hanna Zielińska, Magdalena Jankowska, Justyna Sakowska, Anna Dukat-Mazurek, Grażyna Moszkowska, Bolesław Rutkowski, Alicja Dębska-Ślizień, Piotr Trzonkowski   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

CHARACTERISTICS OF TAND B-CELL SUBPOPULATION PROFILE IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE TREATED WITH VACCINE AGAINST PSEUDOMONAS AERUGINOSA

Медицинская иммунология, 2015
The aim of this study was to evaluate subpopulational profiles of Tand B-lymphocytes in the patients with chronic obstructive pulmonary disease (COPD) under the influence of a multivalent vaccine against Pseudomonas pathogens, in order to justify its ...
A. G. Borisov, A. A. Savchenko, I. V. Kudryavtsev, A. V. Moshev, V. A. Kozlov   +4 more
doaj   +1 more source