Results 41 to 50 of about 693,632 (262)

Ontogeny of mouse B lymphocytes and inactivation by antigen of early B lymphocytes. [PDF]

Proceedings of the National Academy of Sciences, 1976
Taking advantage of recent findings about membrane fluidity, we have studied and compared the biosynthetic capacities of fetal or neonatal mouse B (bone-marrow derived) lymphocytes (until 10 days after birth) and adult B lymphocytes. Although both early and adult lymphocytes can synthesize surface immunoglobulins, they have a different physiological ...
Bruyns, C, Urbain, vansanten G, Planard, C, Vos, cloetens C, Urbain, J   +4 more
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Influence of Bacillus anthracis 34F₂ Sterne Antigen Preparations in Combination with Cobaltarabinogalactan on the Subpopulation Structure of B-lymphocytes (Communication 2)

Эпидемиология и вакцинопрофилактика, 2015
Study of Bacillus anthracis 34F2 Sterne antigenic preparation S-2 and its combined use with nanostructured cobalt-arabinogalaktan (Со-АG) is presented. The ability of these preparations to stimulate proliferation and differentiation of B-lymphocytes is ...
V. V. Voytkova, V. I. Dubrovina, S. V. Lukyanov, O. V. Yuryeva, O. B. Kol’Esnikova, K. M. Korytov, G. P. Aleksandrova, V. P. Iljin, S. V. Balakhonov   +8 more
doaj   +1 more source

Number of T- and B-lymphocytes and their functional activity in the blood of common carps aff ected by Aeromonosis, and in the treatment of probiotic Enteronormin

Науковий вісник ветеринарної медицини, 2020
Fish bacterial infectious diseases are a signifi cant problem for aquaculture, often leading to massive fi sh deaths and signifi cant economic losses. For fi sh treatment often used antibacterial drugs: nitrofuran, antibiotics, feed antibiotics, as well ...
Solopova Kh., Vishchur O.
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Experience of Using Rituximab in a Girl with Severe Systemic Lupus Erythematosus

Педиатрическая фармакология, 2015
Heavy complications of systemic lupus erythematosus, such as the anti-phospholipin syndrome, generalized vaskulit and severe defeats of the central nervous system continue to remain relevant.
A. A. Lebedenko, A. M. Sarychev, A. V. Kharlamova, E. V. Nosova, E. A. Tarasova, K. V. Grin’ko   +5 more
doaj   +1 more source

CD5-Positive B Lymphocytes after Kidney Transplantation

Diagnostics, 2021
Kidney transplantation is the treatment of choice for end-stage kidney diseases. Unfortunately, kidney allograft recipients rarely develop tolerance or accommodation and require life-long immunosuppression.
Maciej Zieliński, Agnieszka Tarasewicz, Hanna Zielińska, Magdalena Jankowska, Justyna Sakowska, Anna Dukat-Mazurek, Grażyna Moszkowska, Bolesław Rutkowski, Alicja Dębska-Ślizień, Piotr Trzonkowski   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

CHARACTERISTICS OF TAND B-CELL SUBPOPULATION PROFILE IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE TREATED WITH VACCINE AGAINST PSEUDOMONAS AERUGINOSA

Медицинская иммунология, 2015
The aim of this study was to evaluate subpopulational profiles of Tand B-lymphocytes in the patients with chronic obstructive pulmonary disease (COPD) under the influence of a multivalent vaccine against Pseudomonas pathogens, in order to justify its ...
A. G. Borisov, A. A. Savchenko, I. V. Kudryavtsev, A. V. Moshev, V. A. Kozlov   +4 more
doaj   +1 more source