Results 81 to 90 of about 1,274,301 (280)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

On Topology of Fuzzy Strong b-Metric Spaces

Journal of New Theory, 2018
In this study, we introduce and investigate the concept of fuzzy strong b-metric space such that is a fuzzy analogy of strong b-metric spaces. By using the open balls, we define a topology on these spaces which is Hausdor® and first countable. Later
Tarkan Oner
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Fixed-Point Results Related to b-Intuitionistic Fuzzy Metric Space

Journal of Function Spaces, 2022
In this study, we contribute to the terminological debate about various fixed-point results’ use of the term intuitionistic fuzzy b-metric space in defining the structure based on fuzzy sets.
Mohamed Altanji, Annamalai Santhi, Vediyappan Govindan, Shyam Sundar Santra, Samad Noeiaghdam   +4 more
doaj   +1 more source

Various Suzuki type theorems in b -metric spaces

Journal of Nonlinear Sciences and Applications, 2015
Summary: In this paper, we prove some fixed point results for \(\alpha\)-admissible mappings which satisfy Suzuki type contractive condition in the setup of \(b\)-metric spaces. Finally, examples are presented to verify the effectiveness and applicability of our main results.
Latif, A., Parvaneh, V., Salimi, P., Al-Mazrooei, A. E.   +3 more
openaire   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Duality and quasi-normability for complexity spaces

Applied General Topology, 2002
The complexity (quasi-metric) space was introduced in [23] to study complexity analysis of programs. Recently, it was introduced in [22] the dual complexity (quasi-metric) space, as a subspace of the function space [0,) ω. Several quasi-metric properties
Salvador Romaguera, M.P. Schellekens
doaj   +1 more source

Partial b_{v}(s) and b_{v}({\theta}) metric spaces and related fixed point theorems

, 2018
In this paper, we introduced two new generalized metric spaces called partial b_{v}(s) and b_{v}({\theta}) metric spaces which extend b_{v}(s) metric space, b-metric space, rectangular metric space, v-generalized metric space, partial metric space ...
Isik, Irfan, Karahan, Ibrahim
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source