Results 91 to 100 of about 456,257 (299)

Generalization Contractive Mappings on Rectangular b-Metric Space

open access: yesAdvances in Mathematical Physics, 2022
In this paper, we introduce new coincidence fixed point theorems for generalized ϕ,ψ-contractive mappings fulfilling kind of an admissibility provision in a Hausdorff b-rectangular metric space with the support of C-functions.
Jayshree Patil   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hyperconvexity and endpoints in T₀-quasi-metric spaces

open access: yes, 2013
Over the last decades much progress has been made in the investigation of hyperconvexity in metric spaces. Recently Kemajou and others have published an article concerning hyperconvexity in T₀-quasi-metric spaces.
Haihambo, Paulus
core  

STUDY ABOUT CYCLIC MAP ON PARTIAL b – METRIC SPACES AND FIXED-POINT THEOREM

open access: yesTikrit Journal of Pure Science, 2018
In this paper, we study the existence and uniqueness of fixed point of cyclic map α-admissible on partial b – metric ...
Muayyad Mahmood Khalil
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Controlled Metric Type Spaces and the Related Contraction Principle

open access: yesMathematics, 2018
In this article, we introduce a new extension of b-metric spaces, called controlled metric type spaces, by employing a control function α ( x , y ) of the right-hand side of the b-triangle inequality.
Nabil Mlaiki   +3 more
doaj   +1 more source

Convexity in quasi-metric spaces

open access: yes, 2012
Includes abstract.Includes bibliographical references.The principal aim of this thesis is to investigate the existence of an injective hull in the categories of T-quasi-metric spaces and of T-ultra-quasi-metric spaces with nonexpansive ...
Otafudu, Olivier Olela
core  

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