Results 171 to 180 of about 30,612,164 (294)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Quasi-Diffusion Imaging: Application to Ultra-High b-Value and Time-Dependent Diffusion Images of Brain Tissue. [PDF]

NMR Biomed
Barrick TR, Ingo C, Hall MG, Howe FA.
europepmc   +1 more source

Both noise-floor and tissue compartment difference in diffusivity contribute to FA dependence on b-value in diffusion MRI. [PDF]

Hum Brain Mapp, 2023
Yao J, Tendler BC, Zhou Z, Lei H, Zhang L, Bao A, Zhong J, Miller KL, He H.   +8 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Deep learning network enhances imaging quality of low-b-value diffusion-weighted imaging and improves lesion detection in prostate cancer. [PDF]

BMC Cancer
Liu Z, Gu WJ, Wan FN, Chen ZZ, Kong YY, Liu XH, Ye DW, Dai B.   +7 more
europepmc   +1 more source

Detection of Hepatic Metastasis in Colorectal Cancer: A Comparative Case Report of ¹⁸F-FDG PET-CT and Diffusion-Weighted MRI with a b Value of 1000. [PDF]

J Belg Soc Radiol, 2023
Fülöp AC, Serac G, Gurzu S.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

New lens on breast health: harnessing high-b-value synthetic diffusion-weighted imaging for breast lesion characterization. [PDF]

Diagn Interv Radiol
Karabiyik S, Ramadan S, Settarzade E, Filiz AI, Ozturkmen Akay H.   +4 more
europepmc   +1 more source

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors. [PDF]

Insights Imaging, 2023
Tang Q, Zhou Q, Chen W, Sang L, Xing Y, Liu C, Wang K, Liu WV, Xu L.   +8 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source