Results 11 to 20 of about 36,705 (202)

Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection of the Nervous System. [PDF]

Brain Sci, 2021
Lyme borreliosis is the most prevalent tick-borne disease in the United States, infecting ~476,000 people annually. Borrelia spp. spirochetal bacteria are the causative agents of Lyme disease in humans and are transmitted by Ixodes spp ticks. Clinical manifestations vary depending on which Borrelia genospecies infects the patient and may be a ...
Ford L, Tufts DM.
europepmc   +5 more sources

Identifying platelet-derived factors as amplifiers of B. burgdorferi-induced cytokine production. [PDF]

Clin Exp Immunol, 2022
AbstractPrevious studies have shown that monocytes can be ‘trained’ or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was found to be important in inducing this phenotype. As we previously found that Borrelia burgdorferi (B. burgdorferi), the causative agent of Lyme borreliosis (LB),
Kerstholt M, van de Schoor FR, Oosting M, Moorlag SJCFM, Li Y, Jaeger M, van der Heijden WA, Tunjungputri RN, Dos Santos JC, Kischkel B, Vrijmoeth HD, Baarsma ME, Kullberg BJ, Lupse M, Hovius JW, van den Wijngaard CC, Netea MG, de Mast Q, Joosten LAB.   +18 more
europepmc   +5 more sources

Tick-Tattoo: DNA Vaccination Against B. burgdorferi or Ixodes scapularis Tick Proteins. [PDF]

Front Immunol, 2021
IntroductionBorrelia burgdorferi sensu lato (sl) is the causative agent of Lyme borreliosis. Currently there is no human vaccine against Lyme borreliosis, and most research focuses on recombinant protein vaccines. DNA tattoo vaccination with B. afzelii strain PKo OspC in mice has proven to be fully protective against B.
Klouwens MJ, Trentelman JJA, Wagemakers A, Ersoz JI, Bins AD, Hovius JW.   +5 more
europepmc   +6 more sources

Culture of Borrelia burgdorferi [PDF]

Journal of Clinical Microbiology, 2001
Marques et al. (2) recently evaluated a new culture medium for the growth of Borrelia burgdorferi from human blood based on a report by Phillips et al. (3). The MPM medium described by Phillips et al. was prepared with Detroit tap water. However, Marques et al.
Richard C. Tilton, Diane Barden, Mary Sand   +2 more
openaire   +1 more source

Borrelia burgdorferi exposure in coyotes: an indicator of B. burgdorferi levels in urban versus rural environments

Veterinary Evidence, 2022
PICO question Do wild coyotes in the US that are in an urban habitat compared to a rural habitat have a higher prevalence of Borrelia burgdorferi seroconversion?   Clinical bottom line Category of research question Prevalence The number and type of study designs reviewed Two papers, both utilising a cross-sectional study design Strength of ...
Laura Shultz, Erik Fausak
openaire   +3 more sources

Identification of Three Species of Borrelia burgdorferi Sensu Lato (B. burgdorferi Sensu Stricto, B. garinii, and B. afzelii) Among Isolates from Acrodermatitis Chronica Atrophicans Lesions [PDF]

Journal of Investigative Dermatology, 1998
In Europe, at least three species of Borrelia are known to be causative agents of Lyme borreliosis: B. burgdorferi sensu stricto, B. garinii, and B. afzelii. Observable differences in the molecular characteristics of the three species have led to speculation that they may also differ in their pathogenic potential and/or tissue tropisms. Several studies
Picken, Roger N., Strle, Franc, Picken, Maria M., Ruzic-Sabljic, Eva, Maraspin, Vera, Lotric-Furlan, Stanka, Cimperman, Joze   +6 more
openaire   +2 more sources

A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.

PLoS Pathogens, 2020
Lyme disease, the most common vector-borne illness in North America, is caused by the spirochete Borrelia burgdorferi. Infection begins in the skin following a tick bite and can spread to the hearts, joints, nervous system, and other organs. Diverse host
Akash Gupta, Gunjan Arora, Connor E Rosen, Zachary Kloos, Yongguo Cao, Jiri Cerny, Andaleeb Sajid, Dieuwertje Hoornstra, Maryna Golovchenko, Natalie Rudenko, Ulrike Munderloh, Joppe W Hovius, Carmen J Booth, Christine Jacobs-Wagner, Noah W Palm, Aaron M Ring, Erol Fikrig   +16 more
doaj   +1 more source

The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. [PDF]

PLoS Pathogens, 2009
The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated.
Joppe W R Hovius, Maarten F Bijlsma, Gerritje J W van der Windt, W Joost Wiersinga, Bastiaan J D Boukens, Jeroen Coumou, Anneke Oei, Regina de Beer, Alex F de Vos, Cornelis van 't Veer, Alje P van Dam, Penghua Wang, Erol Fikrig, Marcel M Levi, Joris J T H Roelofs, Tom van der Poll   +15 more
doaj   +1 more source

A murine model of Lyme disease demonstrates that Borrelia burgdorferi colonizes the dura mater and induces inflammation in the central nervous system.

PLoS Pathogens, 2021
Lyme disease, which is caused by infection with Borrelia burgdorferi and related species, can lead to inflammatory pathologies affecting the joints, heart, and nervous systems including the central nervous system (CNS).
Timothy Casselli, Ali Divan, Emilie E Vomhof-DeKrey, Yvonne Tourand, Heidi L Pecoraro, Catherine A Brissette   +5 more
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Monoinfections caused by Borrelia burgdorferi and Borrelia burgdorferi / Anaplasma phagocytophilum co-infections in forestry workers and farmers

Medycyna Pracy, 2015
Background: The presence of co-infections induced by tick-borne pathogens in humans is an important epidemiological phenomenon. This issue has attracted growing attention of doctors and people working under conditions of an increased risk of being ...
Małgorzata Tokarska-Rodak, Anna Pańczuk, Maria Kozioł-Montewka, Dorota Plewik, Adam Szepeluk   +4 more
doaj   +1 more source