Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening [PDF]
Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of
Babar, Mustafeez Mujtaba +9 more
core +3 more sources
That's my story, and I'm sticking to it—an update on B. burgdorferi adhesins
Adhesion is the initial event in the establishment of any infection. Borrelia burgdorferi, the etiological agent of Lyme disease, possesses myriad proteins termed adhesins that facilitate contact with its vertebrate hosts. B.
C. Brissette, Robert A Gaultney
semanticscholar +1 more source
Borrelia burgdorferi is a spirochetal bacterium that causes Lyme disease. These studies address whether current research methods using either ELISA to detect seroconversion to B.
John J. Lazarus +3 more
doaj +1 more source
Landscape structure affects the prevalence and distribution of a tick-borne zoonotic pathogen [PDF]
Background Landscape structure can affect pathogen prevalence and persistence with consequences for human and animal health. Few studies have examined how reservoir host species traits may interact with landscape structure to alter pathogen communities ...
A Mannelli +66 more
core +5 more sources
Introduction Ticks (Acari: Ixodida) are vectors and/or reservoirs of many pathogens, i.e. Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti .
Marek Asman +4 more
doaj +1 more source
Eco-epidemiology of Borrelia miyamotoi and Lyme borreliosis spirochetes in a popular hunting and recreational forest area in Hungary [PDF]
BACKGROUND: Borrelia miyamotoi, the newly discovered human pathogenic relapsing fever spirochete, and Borrelia burgdorferi sensu lato are maintained in natural rodent populations. The aim of this study was to investigate the natural cycle of B. miyamotoi
Coipan, Elena Claudia +6 more
core +1 more source
Interactions between Borrelia burgdorferi and ticks
Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic metabolic functions and has developed complex interactions with ticks ...
C. Kurokawa +5 more
semanticscholar +1 more source
Ability to cause erythema migrans differs between Borrelia burgdorferi sensu lato isolates [PDF]
Background: Lyme borreliosis is a tick-borne disease caused by Borrelia burgdorferi sensu lato. The variety of characteristic and non-specific clinical manifestations is partially explained by its genetic diversity.
Hengeveld, P. (Paul) +5 more
core +4 more sources
Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice [PDF]
Borrelia burgdorferi produces a mitogen for murine B lymphocytes which can be measured in vitro by polyclonal stimulation of proliferation and immunoglobulin production (R. Schoenfeld, B. Araneo, Y. Ma, L. Yang, and J. J. Weis, Infect. Immun. 60:455-464, 1992). Sonicated B. burgdorferi cells also stimulated IL-6 production by splenocyte cultures.
L, Yang +6 more
openaire +2 more sources
Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States
Borrelia miyamotoi sensu lato, a relapsing fever Borrelia sp., is transmitted by the same ticks that transmit B. burgdorferi (the Lyme disease pathogen) and occurs in all Lyme disease–endemic areas of the United States. To determine the seroprevalence of
Peter J. Krause +16 more
doaj +1 more source

