Results 51 to 60 of about 18,441 (181)

Immune checkpoint inhibitor‐induced eosinophilic fasciitis: A pharmacovigilance and EADV Task force study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A comprehensive retrospective analysis of 121 immune checkpoint inhibitor‐induced eosinophilic fasciitis cases, including clinical presentation, diagnostic features and treatment outcomes using data from the EADV Task Force ‘Dermatology for Cancer Patients’, two international pharmacovigilance databases and the current literature.
Tristan V. M. Bruijn, Alexandre O. Gérard, Maëlys Labat, Zoe Apalla, Wouter van Binsbergen, Dimitra Koumaki, Valerian Rivet, Frederic Dezoteux, Damien Giacchero, Michael R. Ardern‐Jones, Kara Heelan, Jesse P. Hirner, Ander Mayor, Mariette Labots, Markus V. Starink, Conny J. van der Laken, Vincent Sibaud, Yannick S. Elshot   +17 more
wiley   +1 more source

RNA-Seq-based analysis of changes in Borrelia burgdorferi gene expression linked to pathogenicity

Parasites & Vectors, 2015
Background Lyme disease is a global public health problem caused by the spirochaete Borrelia burgdorferi. Our previous studies found differences in disease severity between B. burgdorferi B31- and B. garinii SZ-infected mice.
Qiong Wu, Guiquan Guan, Zhijie Liu, Youquan Li, Jianxun Luo, Hong Yin   +5 more
doaj   +1 more source

Transient marked reactive lymphocytosis in a puppy suspected to be secondary to recent vaccination

Journal of Small Animal Practice, EarlyView.
A 3‐month‐old male Bernese Mountain dog was presented with a 10‐day history of vomiting, vocalisation and abdominal discomfort following vaccination. Physical examination revealed subtle peripheral lymphadenopathy. Haematological testing revealed borderline anaemia, thrombocytopenia and moderate lymphocytosis with a high proportion of reactive or ...
J. Ruel, T. Ternisien, B. Conversy, C. Bedard, C. Lemieux, J. Sparago   +5 more
wiley   +1 more source

Investigating BB0405 as a novel Borrelia afzelii vaccination candidate in Lyme borreliosis

Scientific Reports, 2021
BB0405 is a surface exposed Borrelia burgdorferi protein and its vaccination protected mice against B. burgdorferi infection. As BB0405 is highly conserved across different B.
M. J. Klouwens, J. J. Trentelman, J. I. Ersoz, F. Nieves Marques Porto, R. Sima, O. Hajdusek, M. Thakur, U. Pal, J. W. Hovius   +8 more
doaj   +1 more source

Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi In Vitro. [PDF]

Antibiotics (Basel), 2017
Abstract Lyme disease is a most common vector borne disease in the US. Although the majority of Lyme patients can be cured with the standard 2-4 week antibiotic treatment, at least 10-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS).
Feng J, Zhang S, Shi W, Zhang Y.
europepmc   +4 more sources

Riboflavin Salvage Supports Glycolysis in Borrelia burgdorferi Through Flavin‐Dependent NAD+ Regeneration

Molecular Microbiology, EarlyView.
The Lyme disease agent Borrelia burgdorferi has limited metabolic capabilities and depends on salvage of riboflavin via the BB0316‐BB0319 transport system for generation of critical flavin cofactors FMN and FAD. Riboflavin is important for NAD+ regeneration to fuel glycolysis.
Anna M. Schulz, Grace E. Easterling, Aaditya Balasubramaniyan, Mollie W. Jewett   +3 more
wiley   +1 more source

Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production

Ticks and Tick-Borne Diseases
Interferons (IFNs) are important signaling molecules in the human immune response against micro-organisms. Throughout initial Borrelia burgdorferi sensu lato (B.
Michelle A.E. Brouwer, Zara Karami, Samuel T. Keating, Hedwig Vrijmoeth, Heidi L.M. Lemmers, Helga Dijkstra, Frank L. van de Veerdonk, Mihaela Lupse, Hadewych J.M. ter Hofstede, Mihai G. Netea, Leo A.B. Joosten   +10 more
doaj   +1 more source

Cellular immune response of Amblyomma sculptum and Amblyomma americanum to entomopathogenic fungi: Implications for biological tick control

Medical and Veterinary Entomology, EarlyView.
Amblyomma sculptum showed a plasmatocyte‐dominant haemocyte profile. Beauveria bassiana increased plasmatocytes and reduced granulocytes, whereas Metarhizium robertsii did not cause significant changes. Amblyomma americanum showed a granulocyte‐dominant haemocyte profile. Beauveria bassiana reduced total haemocytes and granulocytes. B.
Cárita de Souza Ribeiro‐Silva, Valesca Henrique Lima, Salorrane Miranda N. Pinto, Gustavo Felizardo S. Sandes, Victor Hugo Ribeiro Costa, Albert Mulenga, Adela S. Oliva Chavez, Éverton Kort Kamp Fernandes   +7 more
wiley   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

From Infection to Anxiety: A Sequential Model Linking Latent Toxoplasmosis to Psychological Distress via Health and Stress

Scandinavian Journal of Psychology, EarlyView.
ABSTRACT Identifying the drivers of chronic stress is crucial for understanding its impact on mental health. Latent toxoplasmosis, a widespread parasitic infection, has been linked to various psychological changes. The Stress‐Coping Hypothesis proposes that at least some of these changes are consequences of chronic stress arising from the infection's ...
Jaroslav Flegr, Ashkan Latifi, Šárka Kaňková   +2 more
wiley   +1 more source