Results 51 to 60 of about 18,726 (190)

Decorin binding proteins of Borrelia burgdorferi promote arthritis development and joint specific post-treatment DNA persistence in mice. [PDF]

PLoS ONE, 2015
Decorin binding proteins A and B (DbpA and B) of Borrelia burgdorferi are of critical importance for the virulence of the spirochete. The objective of the present study was to further clarify the contribution of DbpA and B to development of arthritis and
Jemiina Salo, Annukka Jaatinen, Mirva Söderström, Matti K Viljanen, Jukka Hytönen   +4 more
doaj   +1 more source

Citizen science project on urban canids provides different results from camera traps but generates interest and revenue

Wildlife Biology, EarlyView.
As urbanization increases, wildlife increasingly encounters people. Coyotes Canis latrans and red foxes Vulpes vulpes are two canid species that have readily adapted to urban environments. Citizen science has emerged as a low‐cost method of collecting data on urban‐adapted species that can benefit management agencies but may provide different results ...
Neville F. Taraporevala, Jon P. Beckmann, Julie K. Young   +2 more
wiley   +1 more source

RNA-Seq-based analysis of changes in Borrelia burgdorferi gene expression linked to pathogenicity

Parasites & Vectors, 2015
Background Lyme disease is a global public health problem caused by the spirochaete Borrelia burgdorferi. Our previous studies found differences in disease severity between B. burgdorferi B31- and B. garinii SZ-infected mice.
Qiong Wu, Guiquan Guan, Zhijie Liu, Youquan Li, Jianxun Luo, Hong Yin   +5 more
doaj   +1 more source

Extranodal Marginal Zone Lymphoma: Integrating Etiology, Microenvironment, and Genetics Into Clinical Decision‐Making

European Journal of Haematology, EarlyView.
ABSTRACT Extranodal marginal zone lymphoma (EMZL) represents a unique paradigm among indolent B‐cell neoplasms, in which lymphomagenesis is frequently driven by chronic antigenic stimulation within tissue‐specific microenvironments. Persistent infectious or autoimmune triggers promote the development of ectopic lymphoid tissue and sustain B‐cell ...
Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +15 more
wiley   +1 more source

Investigating BB0405 as a novel Borrelia afzelii vaccination candidate in Lyme borreliosis

Scientific Reports, 2021
BB0405 is a surface exposed Borrelia burgdorferi protein and its vaccination protected mice against B. burgdorferi infection. As BB0405 is highly conserved across different B.
M. J. Klouwens, J. J. Trentelman, J. I. Ersoz, F. Nieves Marques Porto, R. Sima, O. Hajdusek, M. Thakur, U. Pal, J. W. Hovius   +8 more
doaj   +1 more source

Immune checkpoint inhibitor‐induced eosinophilic fasciitis: A pharmacovigilance and EADV Task force study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A comprehensive retrospective analysis of 121 immune checkpoint inhibitor‐induced eosinophilic fasciitis cases, including clinical presentation, diagnostic features and treatment outcomes using data from the EADV Task Force ‘Dermatology for Cancer Patients’, two international pharmacovigilance databases and the current literature.
Tristan V. M. Bruijn, Alexandre O. Gérard, Maëlys Labat, Zoe Apalla, Wouter van Binsbergen, Dimitra Koumaki, Valerian Rivet, Frederic Dezoteux, Damien Giacchero, Michael R. Ardern‐Jones, Kara Heelan, Jesse P. Hirner, Ander Mayor, Mariette Labots, Markus V. Starink, Conny J. van der Laken, Vincent Sibaud, Yannick S. Elshot   +17 more
wiley   +1 more source

Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production

Ticks and Tick-Borne Diseases
Interferons (IFNs) are important signaling molecules in the human immune response against micro-organisms. Throughout initial Borrelia burgdorferi sensu lato (B.
Michelle A.E. Brouwer, Zara Karami, Samuel T. Keating, Hedwig Vrijmoeth, Heidi L.M. Lemmers, Helga Dijkstra, Frank L. van de Veerdonk, Mihaela Lupse, Hadewych J.M. ter Hofstede, Mihai G. Netea, Leo A.B. Joosten   +10 more
doaj   +1 more source

Male genital lichen sclerosus

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Male genital lichen sclerosus is driven by chronic, occluded exposure of susceptible genital epithelium to urine, rather than infection or autoimmunity. This review synthesizes clinical, anatomical and molecular evidence showing how microincontinence and occlusion initiate inflammation, fibrosis and carcinogenesis, and explains the curative effect of ...
Georgios Kravvas, Rory Barry, Richard E. Watchorn, Christopher B. Bunker   +3 more
wiley   +1 more source

Transient marked reactive lymphocytosis in a puppy suspected to be secondary to recent vaccination

Journal of Small Animal Practice, EarlyView.
A 3‐month‐old male Bernese Mountain dog was presented with a 10‐day history of vomiting, vocalisation and abdominal discomfort following vaccination. Physical examination revealed subtle peripheral lymphadenopathy. Haematological testing revealed borderline anaemia, thrombocytopenia and moderate lymphocytosis with a high proportion of reactive or ...
J. Ruel, T. Ternisien, B. Conversy, C. Bedard, C. Lemieux, J. Sparago   +5 more
wiley   +1 more source

Detection of Ring Structure and Its Flexibility in Periplasmic Region of FliL, Bacterial Flagellar Stator‐Associate Protein, in Marine Vibrio

Molecular Microbiology, EarlyView.
FliL, a single‐pass transmembrane flagellar protein with a large periplasmic domain, associates with the basal body and supports motor function under high‐load conditions (e.g., viscous environments). The periplasmic domain of deletion mutant FliL forms a flexible ring structure, likely reflecting the capacity of the full‐length protein to adaptively ...
Tatsuro Nishikino, Norihiro Takekawa, Raymond Burton‐Smith, Yuki Tajimi, Kazuyoshi Murata, Takayuki Uchihashi, Seiji Kojima, Katsumi Imada, Michio Homma   +8 more
wiley   +1 more source