Results 91 to 100 of about 4,634 (162)

Identification and chemogenetic profiling of two antimicrobial auranofin analogs in B. cenocepacia K56-2

, 2023
The Burkholderia cepacia complex (Bcc), a group of Gram-negative multi-drug resistant pathogens are notorious for causing persistent lung infections in people with cystic fibrosis and new antibiotics are needed to treat these infections. One way to find new antimicrobials is to repurpose old drugs for a new use.
openaire   +1 more source

The exopolysaccharide gene cluster Bcam1330–Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c‐di‐GMP and Bcam1349

MicrobiologyOpen, 2012
AbstractIn Burkholderia cenocepacia, the second messenger cyclic diguanosine monophosphate (c‐di‐GMP) has previously been shown to positively regulate biofilm formation and the expression of cellulose and type‐I fimbriae genes through binding to the transcriptional regulator Bcam1349. Here, we provide evidence that cellulose and type‐I fimbriae are not
Mustafa Fazli, Yvonne McCarthy, Michael Givskov, Robert P. Ryan, Tim Tolker‐Nielsen   +4 more
openaire   +1 more source

In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology

Frontiers in Virology
BackgroundMultidrug-resistant Burkholderia cenocepacia and Burkholderia multivorans have emerged as significant pathogens, particularly in patients with cystic fibrosis (CF) and chronic granulomatous disease (CGD).ObjectiveGiven the absence of approved ...
Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti   +10 more
doaj   +1 more source

Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex

BMC Genomics, 2008
Background The Burkholderia cepacia complex (BCC) is a versatile group of Gram negative organisms that can be found throughout the environment in sources such as soil, water, and plants.
Shrivastava Savita, Stothard Paul, Seed Kimberley D, Lynch Karlene H, Goudie Amanda D, Wishart David S, Dennis Jonathan J   +6 more
doaj   +1 more source

Regulation of morpheein behavior in B. cenocepacia HMG-CoA reductase [PDF]

Acta Crystallographica Section A Foundations and Advances, 2018
Jeff Watson, Chad Hicks, Jean-Claude Abboud   +2 more
openaire   +1 more source

<b>Chronic Urinary Tract Infection Due to Burkholderia cenocepacia in an Immunocompetent Adult Without Risk Factors: A Rare Case Report</b>

Journal of Health, Wellness and Community Research
Background: Burkholderia cenocepacia, a multidrug-resistant member of the Burkholderia cepacia complex, is an opportunistic pathogen rarely implicated in urinary tract infections (UTIs). Reported cases almost exclusively involve immunocompromised or catheterized patients.
null Khalid Hussain, null Maria Tariq, null Jawad Ahmed, null Ahmad Ur Rehman, null Khansa Mahnoor   +4 more
openaire   +1 more source

Forty-year single-center experience of Burkholderia cystic fibrosis airway infections

International Journal of Infectious Diseases
Objectives: To resolve the epidemiology of airway infections with Burkholderia cepacia complex (Bcc) in patients with cystic fibrosis (pwCFs) over 40 years at a single treatment center.
Burkhard Tümmler, Jutta Ulrich, Ludwig Sedlacek   +2 more
doaj   +1 more source

In vitro antibacterial efficacy of Acacia farnesiana seed extracts specifically directed against B. cepacia , B. multivorans, B. cenocepacia of Burkholderia cepacia complex

Annals of the National Academy of Medical Sciences (India)
Objectives The emergence of antibiotic-resistant pathogens and the constraints of existing pharmaceuticals have intensified the quest for alternative therapeutic strategies. Phytochemically-rich plant and seed extracts present a promising avenue for the development of novel antimicrobial agents.
Sunil Kumar Mugle, Jasmeet Kaur Sohal
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Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B.

The Journal of biological chemistry, 2009
Burkholderia cenocepacia is an opportunistic pathogen that displays a remarkably high resistance to antimicrobial peptides. We hypothesize that high resistance to antimicrobial peptides in these bacteria is because of the barrier properties of the outer membrane.
Ortega X, SILIPO, ALBA, Saldías MS, Bates CC, MOLINARO, ANTONIO, Valvano M.A.   +5 more
openaire   +3 more sources

Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages [PDF]

Cellular Microbiology, 2013
Souhaila Al-Khodor, Kimberly Marshall-Batty, Vinod Nair, Li Ding, David E. Greenberg, Iain D. C. Fraser   +5 more
openaire   +1 more source