Results 41 to 50 of about 627,044 (290)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Selective One-Pot Multicomponent Synthesis of N-Substituted 2,3,5-Functionalized 3-Cyanopyrroles via the Reaction between α-Hydroxyketones, Oxoacetonitriles, and Primary Amines

Molecules, 2022
A one-step, three-component reaction between α-hydroxyketones, oxoacetonitriles, and primary amines gives N-substituted 2,3,5-functionalized 3-cyanopyrroles with complete selectivity in up to 90% isolated yields.
Mengxin Xia, Ziad Moussa, Zaher M. A. Judeh   +2 more
doaj   +1 more source

Estudo dos mecanismos envolvidos nas respostas contráteis induzidas por agonistas B1 e B2 para as cininas em cólons de camundongos: influência da colite induzida por TNBS [PDF]

, 2007
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaO presente estudo analisou através de técnicas farmacológicas alguns mecanismos envolvidos na resposta contrátil induzida ...
Hara, Daniela Balz
core  

Kinin-B1 receptors in ischaemia-induced pancreatitis: Functional importance and cellular localisation [PDF]

, 2003
In this study we compare the role of kininB1 and B2 receptors during ischaemia/reperfusion of rat pancreas. Our investigations were prompted by the observation that infusion of a kininB2 receptor antagonist produced significant improvement in acute ...
A. A. Roscher, Messmer, Konrad, Hoffmann, Tomas F., J. F. Kuebler, Kuebler, Joachim F., Bhoola, Kanti D., E. Schremmer-Danninger, Roscher, Adelbert A., T. F. Hoffmann, K. Messmer, Schremmer-Danninger, Elisabeth, K. D. Bhoola   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Envolvimento dos receptores B1 e B2 das cininas no extravasamento plasmático induzido pela bradicinina e desArg9-bradicinina na dura-máter de ratos [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Envolvimento dos receptores B1 e B2 das cininas no extravasamento plasmático (EP) induzido pela bradicinina (BK) e ...
Waltrick, Pablo Tortato
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Uma Nova visão da participação dos receptores B1 e B2 para cininas na dor neuropática orofacial [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011Embora pouco prevalente entre a população, a neuralgia do trigêmeo é uma das condições mais dolorosas.
Luiz, Ana Paula
core  

Visualisation of tissue kallikrein, kininogen and kinin receptors in human skin following trauma and in dermal diseases [PDF]

, 2004
During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunctional substrates (kininogens) to form bradykinin and kallidin.
Valeske, Klaus, Strinivasen Naidoo, Elisabeth Schremmer-Danninger, Heinz Neuhof, Neuhof, Christiane, Schremmer-Danninger, Elisabeth, Kanti D. Bhoola, Celia Snyman, Christiane Neuhof, Neuhof, Heinz, Bhoola, Kanti D., Klaus Valeske, Snyman, Celia, Sander, Christian, Christian Sander, Naidoo, Strinivasen   +15 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source