Results 51 to 60 of about 627,044 (290)

Salting the charged surface: pH and salt dependence of protein G B1 stability. [PDF]

, 2006
This study shows significant effects of protein surface charges on stability and these effects are not eliminated by salt screening. The stability for a variant of protein G B1 domain was studied in the pH-range of 1.5-11 at low, 0.15 M, and 2 M salt ...
Xue, Wei-Feng, Linse, Sara,, Bauer, Mikael C., Szczepankiewicz, Olga, Bauer, Mikael,, Lindman, Stina, Wei-Feng Xue, Xue, Wei-Feng,, Nilsson, Hanna,, Szczepankiewicz, Olga,, Stina Lindman, Olga Szczepankiewicz, Mikael C. Bauer, Hanna Nilsson, Lindman, Stina,, Nilsson, Hanna, Bauer, Mikael, Sara Linse, Linse, Sara, Lund University.   +19 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Hyperforin Exhibits Antigenotoxic Activity on Human and Bacterial Cells

Molecules, 2017
Hyperforin (HF), a substance that accumulates in the leaves and flowers of Hypericum perforatum L. (St. John’s wort), consists of a phloroglucinol skeleton with lipophilic isoprene chains. HF exhibits several medicinal properties and is mainly used as an
Petronela Imreova, Jana Feruszova, Stanislav Kyzek, Kristina Bodnarova, Martina Zduriencikova, Katarina Kozics, Pavel Mucaji, Eliska Galova, Andrea Sevcovicova, Eva Miadokova, Ivan Chalupa   +10 more
doaj   +1 more source

Genetic alterations in epilepsy: the cases of Unverricht- Lundborg disease, Fragile X and B1 null mutation [PDF]

, 2009
Genetic mechanisms are estimated to underlie about 40% of epilepsies and may present with different manifestations and syndromes. In this thesis, three different cases of genetic implications in epilepsy have been studied: Unverricht-Lundborg disease ...
Buzzi, Andrea
core  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Avaliação do papel dos receptores B1 e B2 para as cininas na modulação da encefalomielite autoimune experimental [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA Esclerose Múltipla (EM) é uma doença inflamatória crônica e progressiva, a qual desencadeia desmielinização no sistema ...
Dutra, Rafael Cypriano
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Conceitos do manejo integrado do fogo para promoção e estabilização de ecossistemas resilientes

Biodiversidade Brasileira, 2019
O fogo é um elemento de transformação e modelagem dos ambientes naturais, utilizado como ferramenta de manejo pelo homem há milhares de anos. O seu uso de forma controlada é indicado, e tem sido defendido por especialistas, para regiões limítrofes às ...
Daniel Almeida Rocha
doaj   +3 more sources

Síntese de potenciais antagonistas do receptor b1 da bradicinina contendo o heterociclo dihidropiridazinona [PDF]

, 2010
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Com base nas estruturas de seletivos antagonistas não peptídicos do receptor B1 da bradicinina, foram desenvolvidos novos análogos ...
Maximiano, Adrielle Patricio
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source