Results 111 to 120 of about 47,090 (208)

Immunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer

Frontiers in Medicine
IntroductionProstate cancer remains a major global health challenge, necessitating precision immunotherapeutic strategies tailored to tumor-associated antigens.
Stefanus Vicky Bernhard Elisa Runtunuwu, Trina Ekawati Tallei, Trina Ekawati Tallei, Trina Ekawati Tallei, Hyo Jeong Kim, Moon Nyeo Park, Moon Nyeo Park, Ismail Celik, Burak Kirilmaz, Grace Lendawati Amelia Turalaki, Fatimawali Fatimawali, Lydia Estelina Naomi Tendean, Martha Marie Kaseke, Dionisius Rafael Makawaehe, Elne Vieke Rambi, Bonglee Kim, Bonglee Kim   +16 more
doaj   +1 more source

Jiuwei Xiaozhi Decoction Alleviates High‐Fat Diet‐Induced MASLD by Suppressing Hepatic SREBP2‐Driven Cholesterogenesis and Restoring PPARα‐Mediated Fatty Acid Oxidation

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Studies have found that Jiuwei Xiaozhi Decoction can improve high‐fat diet‐induced fatty liver disease, mainly by regulating the SREBP2 and PPARα pathways to balance hepatic lipid metabolism while reducing inflammatory responses. ABSTRACT Jiuwei Xiaozhi Decoction (JWXZ) is a nine‐herb traditional Chinese medicine formula clinically used for hepatic ...
Youcheng Ma, Xinrui Gao, Ji Wang, Lingru Li, Zhen Huang, Fangli Li   +5 more
wiley   +1 more source

Patient‐Derived IgG Epitope Mapping of Bet v 1 Reveals Hypoallergenic Peptide Candidates for Safe and Next‐Generation Allergen Immunotherapy

Clinical &Experimental Allergy, Volume 56, Issue 8, Page 881-892, August 2026.
Mapping IgG epitopes of the major birch allergen Bet v 1 identified patient‐derived, hypoallergenic peptides that did not trigger degranulation. These findings support a novel, safer approach for peptide‐based allergen immunotherapy that leverages naturally induced IgG specificities from allergic individuals. ABSTRACT Background Allergen immunotherapy (
Lara Šošić, Marta Paolucci, Alessandro Streuli, David A. Melillo, Tianchi Jiang, Raffaela Campana, Claudia C. V. Lang, Thomas M. Kündig, Christian Steuer, Klaus Eyer, Pål Johansen   +10 more
wiley   +1 more source

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment

Immunology &Cell Biology, Volume 104, Issue 7, Page 711-728, August 2026.
Three interconnected processes in glioblastoma (GBM) biology: initiation, stratification, and immunosuppression. 1) Initiation: GBM initiation is proposed to occur through migration of TERT mutation‐bearing neural stem cells from the subventricular zone to the frontal and temporal cortices, where a subsequent oncogenic transformation drives their ...
Emerson Achari, Farah Ahmady‐Nield, Amit Sharma, Ingo G. H. Schmidt‐Wolf, Jarek Maciaczyk, Rodney B. Luwor, Adrian A. Achuthan   +6 more
wiley   +1 more source

Emerging Immune‐Based Therapeutic Strategies in Hepatocellular Carcinoma

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide despite recent advances in systemic therapy. The introduction of immune checkpoint inhibitors has substantially expanded treatment options for advanced disease; however, durable responses are observed only in a subset of patients.
Janine Kah, Werner Dammermann, Stefan Lueth   +2 more
wiley   +1 more source

B7 homolog 3-targeted CAR-T cells secreting EGFR T-cell engagers for improved control of glioblastoma progression. [PDF]

Mol Biomed
Zhang Z, Yang N, Zeng H, Chen Y, Lu H, Xu L, Wang Z, Wang G, Zhou L, Tong A.   +9 more
europepmc   +1 more source

B7-H3 CAR T cells eradicate intrahepatic cholangiocarcinoma and induce durable response. [PDF]

J Exp Clin Cancer Res
Arya S, Ventin M, Cattaneo G, Nebbia M, Sanatkar SA, Martin C, Jia J, Kim B, Bailey CA, Bardeesy NM, Ting DT, Deshpande V, Wang X, Ryeom S, Ferrone S, Ferrone CR.   +15 more
europepmc   +1 more source

B7-H4: a multifaceted immune checkpoint and oncoprotein in cancer biology and immunotherapy. [PDF]

Front Immunol
Zhang C, Miao Z, Cao J, Wang X, Shi T.
europepmc   +1 more source

Igniting cold tumors: reprogramming the tumor immune microenvironment with dual-payload ADCs in combination with PD-L1&4-1BB bispecific antibodies. [PDF]

J Immunother Cancer
Pan J, Yuan X, Yu H, Liu Z, Chen S, Zhu F, Shang Y, Hong S, Han X, Zhu Z, Jin T, Pan Y, Zhou S.   +12 more
europepmc   +1 more source

B7-H3 membranous expression correlates with histological grading in a two-center cohort of 133 pre-treatment bone and soft tissue sarcoma samples. [PDF]

BMC Cancer
Kloker LD, Rottscholl R, Heitmann JS, Bronsert P, Braig D, Benzler K, Zender L, Deinzer CKW.   +7 more
europepmc   +1 more source