Results 1 to 10 of about 46,982 (194)

B7 homolog 3-targeted CAR-T cells secreting EGFR T-cell engagers for improved control of glioblastoma progression [PDF]

Molecular Biomedicine
Glioblastoma (GBM) is the most aggressive primary malignant brain tumor, and while chimeric antigen receptor-T (CAR-T) cell therapy has shown promise, its efficacy remains limited by antigen heterogeneity and immune escape.
Zongliang Zhang, Nian Yang, Hui Zeng, Yongdong Chen, Huaqing Lu, Long Xu, Zeng Wang, Guoqing Wang, Liangxue Zhou, Aiping Tong   +9 more
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Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy [PDF]

Cell Reports Medicine
Summary: B7-H3 is a cell surface protein overexpressed in many solid tumors and an attractive target for chimeric antigen receptor (CAR) T cell therapy.
Pradip Bajgain, Yang Feng, Mariela Puebla, Meijie Tian, Kuo-Sheng Hsu, Jaewon Lee, GuoJun Yu, Liping Yang, Steven Seaman, Mary Beth Hilton, Karen Morris, Niza Borchin, Jennifer D. Tran, Riley D. Metcalfe, Dan Li, Mitchell Ho, James C. Cronk, Javed Khan, Anandani Nellan, Rosandra N. Kaplan, Brad St. Croix   +20 more
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B7-H3 (CD276) as Target for T Cell-Based Bispecific Antibody Therapy of Penile Cancer [PDF]

ImmunoTargets and Therapy
Aleksander Kielbik,1– 3 Veronika Bahlinger,3,4 Christian M Schürch,3,4 Maria Luisa Barcena,2 Olesya Vakhrusheva,2 Anita Thomas,5 Igor Tsaur,2 Jonas S Heitmann,1,3 Helmut R Salih,1,3,6 Ilona Hagelstein1,3,6 1Clinical Collaboration Unit Translational ...
Kielbik A, Bahlinger V, Schürch CM, Barcena ML, Vakhrusheva O, Thomas A, Tsaur I, Heitmann JS, Salih HR, Hagelstein I   +9 more
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Plasma extracellular vesicle proteomics nominates candidate biomarkers of 177Lu-PSMA-617 outcomes in metastatic prostate cancer patients [PDF]

Cell Reports Medicine
Summary: 177Lu-PSMA-617 represents a transformative treatment for metastatic castration-resistant prostate cancer (mCRPC), yet biomarkers of benefit beyond prostate-specific membrane antigen positron emission tomography (PSMA-PET) imaging remain lacking.
Ali T. Arafa, Ella Boytim, Megan L. Ludwig, Lily Kollitz, Tianzhong Yang, Kathleen M. Storey, Stuart Bloom, Gautam Jha, Ian Okazaki, Charles J. Ryan, Nicholas A. Zorko, Daniel Steinberger, Zuzan Cayci, Yingchun Zhao, Peter W. Villalta, Scott M. Dehm, Justin H. Hwang, Justin M. Drake, Emmanuel S. Antonarakis   +18 more
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Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

npj Precision Oncology, 2022
B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target.
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang   +13 more
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Augmented Innate and Adaptive Immune Responses Under Conditions of Diabetes–Filariasis Comorbidity

Frontiers in Immunology, 2021
Metainflammation, as seen in chronic diabetes subjects, impairs immunity and increases the susceptibility to infections. In the present study, the effect of diabetes on immune response against filariasis was studied.
Joy Manohar Sibi, Viswanathan Mohan, Saravanan Munisankar, Subash Babu, Vivekanandhan Aravindhan   +4 more
doaj   +1 more source

The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

Journal of Biomedical Science, 2023
Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulatory receptors B7-1(
Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka, Raymond Kaempfer   +8 more
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Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Scientific Reports, 2023
Chlamydia pneumoniae (C. pneumoniae) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective preventive vaccine essential. In this study, a multi-epitope vaccine with CTLA-4 extracellular structure
Xiaomei Guo, Xiaohong Pan, Qiangming Sun, Yunzhang Hu, Jiandong Shi   +4 more
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Bioinformatics-based design of a fusion vaccine with CTLA-4 variable region to combat Brucella

Brazilian Journal of Medical and Biological Research, 2023
Brucellosis has become a global zoonotic disease, seriously endangering the health of people all over the world. Vaccination is an effective strategy for protection against Brucella infection in livestock in developed countries. However, current vaccines
W.H. Guo, Y.J. Zhu, G. Haimiti, X.R. Xie, C. Niu, M. Li, J. Shi, Z.W. Yin, M.K. Yu, J.B. Ding, F.B. Zhang   +10 more
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Inhibition of colorectal cancer targets IL-6, CTLA-4, & B7-2 by Tislelizumab: molecular docking, dynamics, & STRING protein-protein network analysis

Informatics in Medicine Unlocked, 2023
As a DNA mismatch repair deficit (dMMR) anticancer medication, and a humanized monoclonal antibody (hmAb), Tislelizumab has attracted significant interest in recent years.
Mahmoud Elkazzaz, Shahid Ullah, Tianshun Gao, Israa M. Shamkh, Amr Ahmed, Ted X. Wu, Maii S. Elsharayidi, Mohammad Shahbaz Khan, Aziz-ur Rehman, Marwa M. Lotfy, Abdullah Haikal, Mahmoud Abdalrahman   +11 more
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