Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase. [PDF]
PLoS ONE, 2014 The association of B7-1/CD28 between antigen presenting cells (APCs) and T-cells provides a second signal to proliferate and activate T-cell immunity at the induction phase.
Xiao-Lin Li +16 more
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Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy [PDF]
Cell Reports MedicineSummary: B7-H3 is a cell surface protein overexpressed in many solid tumors and an attractive target for chimeric antigen receptor (CAR) T cell therapy.
Pradip Bajgain +20 more
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Prognostic and therapeutic roles of B7-H3 and B7-H4 in prostate cancer [PDF]
Discover OncologyProstate cancer (PCa) remains a leading cause of cancer-related morbidity and mortality in men worldwide, with metastatic castration-resistant prostate cancer (mCRPC) presenting a particularly formidable therapeutic challenge.
Yunxi Hu +3 more
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Alternative immune checkpoints in immunoregulatory profile of cancer stem cells
Heliyon, 2023 Tumor-mediated bypass of immune checkpoint inhibitor (ICI) therapy with anti-programmed death-1 (PD-1), anti-programmed death-ligand 1 (PD-L1, also called B7–H1 or CD274) or anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a challenge of ...
Keywan Mortezaee, Jamal Majidpoor
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Augmented Innate and Adaptive Immune Responses Under Conditions of Diabetes–Filariasis Comorbidity
Frontiers in Immunology, 2021 Metainflammation, as seen in chronic diabetes subjects, impairs immunity and increases the susceptibility to infections. In the present study, the effect of diabetes on immune response against filariasis was studied.
Joy Manohar Sibi +4 more
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Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo? [PDF]
The Journal of experimental medicine, 1996 Tumors engineered to express the costimulatory molecule B7-1 can elicit CD8+ cytotoxic T lymphocyte (CTL)-dependent antitumor responses in immunocompetent mice. It has been postulated that this result reflects direct priming of CTL by the modified tumor in vivo.
A Y, Huang +3 more
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Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens. [PDF]
Proceedings of the National Academy of Sciences, 1994 Resting epidermal keratinocytes do not express B7-1 and other known CD28 counterligands with costimulatory activity. The absence of these costimulators on keratinocytes correlates with their ability to preferentially induce T-cell anergy instead of T-cell activation.
I R, Williams, R J, Ort, T S, Kupper
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B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28 [PDF]
The Journal of Experimental Medicine, 1998 Ligation of cytotoxic T lymphocyte antigen 4 (CTLA4) appears to inhibit T cell responses. Four mechanisms have been proposed to explain the inhibitory activity of CTLA4: competition for B7-1 and B7-2 binding by CD28; sequestration of signaling molecules away from CD28 via endocytosis; delivery of a signal that antagonizes a CD28 signal; and delivery of
F, Fallarino, P E, Fields, T F, Gajewski
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Journal of Biomedical Science, 2023 Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulatory receptors B7-1(
Andrey Popugailo +8 more
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Construction and Characterization of a Triple-Recombinant Vaccinia Virus Encoding B7-1, Interleukin 12, and a Model Tumor Antigen [PDF]
JNCI Journal of the National Cancer Institute, 1998 Construction of recombinant viruses that can serve as vaccines for the treatment of experimental murine tumors has recently been achieved. The cooperative effects of immune system modulators, including cytokines such as interleukin 12 (IL-12) and costimulatory molecules such as B7-1, may be necessary for activation of cytotoxic T lymphocytes.
M W, Carroll +5 more
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