Results 11 to 20 of about 30,012,915 (215)

Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions

Drug Design, Development and Therapy, 2014
Andreas O Doesch,1,* Li Zhao,1,* Christian A Gleissner,1 Mohammadreza Akhavanpoor,1 David Rohde,1 Deniz Okuyucu,1 Maani Hakimi,2 Thomas J Dengler,3 Hugo A Katus,1 Christian Erbel1 1Department of Cardiology, 2Department of Vascular Surgery, University of ...
Doesch AO, Zhao L, Gleissner CA, Akhavanpoor M, Rohde D, Okuyucu D, Hakimi M, Dengler TJ, Katus HA, Erbel C   +9 more
doaj   +1 more source

Tissue Factor-High Ovarian Clear Cell Carcinoma Shows Immune-Cold Features and Preclinical Activity of Tisotumab Vedotin. [PDF]

Cancer Sci
F3/TF‐high ovarian clear cell carcinoma exhibits an immune‐cold phenotype characterized by reduced immune‐cell fractions and attenuated cancer‐cell interferon programs, with frequent B7‐H4 co‐expression. Patient‐derived models show preclinical sensitivity to the TF‐directed antibody–drug conjugate tisotumab vedotin.
Mori Y, Tamura R, Takahashi K, Yamawaki K, Ishiguro T, Motoyama T, Okamoto K, Yoshihara K.   +7 more
europepmc   +2 more sources

High TIL, HLA, and Immune Checkpoint Expression in Conventional High-Grade and Dedifferentiated Chondrosarcoma and Poor Clinical Course of the Disease

Frontiers in Oncology, 2021
PurposeThe aim of this study was to characterize chondrosarcoma tumor infiltration by immune cells and the expression of immunologically relevant molecules.
Sjoerd P. F. T. Nota, Sjoerd P. F. T. Nota, Ahmad Al-Sukaini, Ahmad Al-Sukaini, Shalin S. Patel, Shalin S. Patel, Francesco Sabbatino, G. Petur Nielsen, G. Petur Nielsen, Vikram Deshpande, Vikram Deshpande, Jennifer H. Yearley, Soldano Ferrone, Soldano Ferrone, Xinhui Wang, Joseph H. Schwab, Joseph H. Schwab   +16 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Bioinformatics-based design of a fusion vaccine with CTLA-4 variable region to combat Brucella

Brazilian Journal of Medical and Biological Research, 2023
Brucellosis has become a global zoonotic disease, seriously endangering the health of people all over the world. Vaccination is an effective strategy for protection against Brucella infection in livestock in developed countries. However, current vaccines
W.H. Guo, Y.J. Zhu, G. Haimiti, X.R. Xie, C. Niu, M. Li, J. Shi, Z.W. Yin, M.K. Yu, J.B. Ding, F.B. Zhang   +10 more
doaj   +1 more source

THE PD-1/B7-H1-MEDIATED PRO-APOPTOTIC ACTIVITY OF DENDRITIC CELLS AS A POSSIBLE MECHANISM OF ANTIGEN-SPECIFIC RESPONSE FAILURE IN PATIENTS WITH PULMONARY TUBERCULOSIS

Медицинская иммунология, 2014
. The aim of present study was to investigate PD-1/B7-H1-mediated induction of T-cell apoptosis/ anergy, a suggested mechanism of reduced antigen-specific immune response against M. tuberculosis.
L. V. Sakhno, M. A. Tikhonova, T. V. Tyrinova, O. Yu. Leplina, S. D. Niconov, O. A. Zhdanov, A. A. Ostanin, E. R. Chernykh   +7 more
doaj   +1 more source

Soluble B7-CD28 Family Inhibitory Immune Checkpoint Proteins and Anti-Cancer Immunotherapy

Frontiers in Immunology, 2021
Co-inhibitory B7-CD28 family member proteins negatively regulate T cell responses and are extensively involved in tumor immune evasion. Blockade of classical CTLA-4 (cytotoxic T lymphocyte-associated antigen-4) and PD-1 (programmed cell death protein-1 ...
Muhammad Khan, Muhammad Khan, Sumbal Arooj, Hua Wang, Hua Wang   +4 more
doaj   +1 more source

Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Scientific Reports, 2023
Chlamydia pneumoniae (C. pneumoniae) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective preventive vaccine essential. In this study, a multi-epitope vaccine with CTLA-4 extracellular structure
Xiaomei Guo, Xiaohong Pan, Qiangming Sun, Yunzhang Hu, Jiandong Shi   +4 more
doaj   +1 more source

Differential Effects of Cytokines and Immunosuppressive Drugs on CD40, B7–1, and B7–2 Expression on Purified Epidermal Langerhans Cells [PDF]

, 1999
Langerhans cells are MHC class II antigen-positive antigen-presenting cells in the epidermis. Recent studies have revealed that Langerhans cells express costimulatory molecules like B7–1 and B7–2 and the accessory molecule CD40.
Tada, Yayoi, Tamaki, Kunihiko, Sugaya, Makoto, Fukuda, Satoru, Salgado, Claudio Guedes, Nakamura, Koichiro, Koyama, Yoh-ichi, Irie, Shinkichi, Asahina, Akihiko   +8 more
core   +1 more source

Inhibition of colorectal cancer targets IL-6, CTLA-4, & B7-2 by Tislelizumab: molecular docking, dynamics, & STRING protein-protein network analysis

Informatics in Medicine Unlocked, 2023
As a DNA mismatch repair deficit (dMMR) anticancer medication, and a humanized monoclonal antibody (hmAb), Tislelizumab has attracted significant interest in recent years.
Mahmoud Elkazzaz, Shahid Ullah, Tianshun Gao, Israa M. Shamkh, Amr Ahmed, Ted X. Wu, Maii S. Elsharayidi, Mohammad Shahbaz Khan, Aziz-ur Rehman, Marwa M. Lotfy, Abdullah Haikal, Mahmoud Abdalrahman   +11 more
doaj   +1 more source