Results 11 to 20 of about 47,090 (208)

B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models

OncoImmunology, 2020
The application of chimeric antigen receptor (CAR)-T cell therapy in patients with advanced solid tumors remains a significant challenge. Simultaneously targeting antigen and the solid tumor microenvironment are two major factors that greatly impact CAR ...
Baozhu Huang, Liqun Luo, Jun Wang, Bailin He, Rui Feng, Na Xian, Qiong Zhang, Lieping Chen, Gangxiong Huang   +8 more
doaj   +1 more source

Efficacy of B7-H3-Redirected BiTE and CAR-T Immunotherapies Against Extranodal Nasal Natural Killer/T Cell Lymphoma

Translational Oncology, 2020
Extranodal nasal natural killer (NK)/T cell lymphoma (ENKTCL) is a rare but highly aggressive subtype of non-Hodgkin lymphoma (NHL). Nevertheless, despite extensive research, the estimated 5-year overall survival of affected patients remains low ...
Meijun Zheng, Lingyu Yu, Juanjuan Hu, Zongliang Zhang, Haiyang Wang, Dan Lu, Xin Tang, Jianhan Huang, Kunhong Zhong, Zeng Wang, Yisong Li, Gang Guo, Shixi Liu, Aiping Tong, Hui Yang   +14 more
doaj   +1 more source

Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

Journal of Experimental & Clinical Cancer Research, 2021
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different ...
Hao Zhang, Ziyu Dai, Wantao Wu, Zeyu Wang, Nan Zhang, Liyang Zhang, Wen-Jing Zeng, Zhixiong Liu, Quan Cheng   +8 more
doaj   +1 more source

Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells [PDF]

International Immunology, 1997
Transfection of modestly immunogenic tumors to express B7 family co-stimulator molecules results in their rejection by syngeneic mice, suggesting a possible clinical application in cancer patients. Immunization of naive mice with irradiated B7-1-transfected P1.HTR cells is sufficient to induce specific cytolytic T lymphocytes (CTL) and to protect ...
F, Fallarino, A, Ashikari, T, Boon, T F, Gajewski   +3 more
openaire   +2 more sources

T Cell Mediated Antibody lnvariance in an Immune Response Against A Bacterial Carbohydrate Antigen Requires CD28/B7–1 Costimulation [PDF]

Journal of Immunology Research, 2001
The humoral immune response against α(1 → 3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals however, the response proceeds to a vigorous IgG production.
Rademaekers, André, Kölsch, Eckehart, Specht, Christoph   +2 more
openaire   +2 more sources

High TIL, HLA, and Immune Checkpoint Expression in Conventional High-Grade and Dedifferentiated Chondrosarcoma and Poor Clinical Course of the Disease

Frontiers in Oncology, 2021
PurposeThe aim of this study was to characterize chondrosarcoma tumor infiltration by immune cells and the expression of immunologically relevant molecules.
Sjoerd P. F. T. Nota, Sjoerd P. F. T. Nota, Ahmad Al-Sukaini, Ahmad Al-Sukaini, Shalin S. Patel, Shalin S. Patel, Francesco Sabbatino, G. Petur Nielsen, G. Petur Nielsen, Vikram Deshpande, Vikram Deshpande, Jennifer H. Yearley, Soldano Ferrone, Soldano Ferrone, Xinhui Wang, Joseph H. Schwab, Joseph H. Schwab   +16 more
doaj   +1 more source

Bioinformatics-based design of a fusion vaccine with CTLA-4 variable region to combat Brucella

Brazilian Journal of Medical and Biological Research, 2023
Brucellosis has become a global zoonotic disease, seriously endangering the health of people all over the world. Vaccination is an effective strategy for protection against Brucella infection in livestock in developed countries. However, current vaccines
W.H. Guo, Y.J. Zhu, G. Haimiti, X.R. Xie, C. Niu, M. Li, J. Shi, Z.W. Yin, M.K. Yu, J.B. Ding, F.B. Zhang   +10 more
doaj   +1 more source

Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen. [PDF]

Proceedings of the National Academy of Sciences, 1996
There is a need for more effective therapy for chronic virus infections. A principle natural mechanism for elimination of virus-infected host cells is activation of viral antigen-specific cytotoxic T lymphocytes (CTL). In an effort to develop methods of inducing virus-specific CTL responses that might be utilized in therapy of virus infections, we have
X S, He, H S, Chen, K, Chu, M, Rivkina, W S, Robinson   +4 more
openaire   +2 more sources

THE PD-1/B7-H1-MEDIATED PRO-APOPTOTIC ACTIVITY OF DENDRITIC CELLS AS A POSSIBLE MECHANISM OF ANTIGEN-SPECIFIC RESPONSE FAILURE IN PATIENTS WITH PULMONARY TUBERCULOSIS

Медицинская иммунология, 2014
. The aim of present study was to investigate PD-1/B7-H1-mediated induction of T-cell apoptosis/ anergy, a suggested mechanism of reduced antigen-specific immune response against M. tuberculosis.
L. V. Sakhno, M. A. Tikhonova, T. V. Tyrinova, O. Yu. Leplina, S. D. Niconov, O. A. Zhdanov, A. A. Ostanin, E. R. Chernykh   +7 more
doaj   +1 more source

Defective antigen‐presenting cell function in patients with systemic lupus erythematosus: Role of the B7‐1 (CD80) costimulatory molecule [PDF]

Arthritis & Rheumatism, 1996
AbstractObjective. Patients with systemic lupus erythematosus (SLE) who exhibit defective in vitro responses to recall antigens and normal responses to alloantigens have been shown to have an abnormality in antigenpresenting cell (APC) function. This study was undertaken to further characterize this defect in APC function in lupus patients.Methods ...
George C. Tsokos, Birgit Kovacs, Peter P. Sfikakis, Stamatis Theocharis, Scott Vogelgesang, Charles S. Via   +5 more
openaire   +1 more source