Results 31 to 40 of about 47,090 (208)

B7-1/B7-2 Costimulation Regulates Plaque Antigen–Specific T-Cell Responses and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice [PDF]

Circulation, 2004
Background— Several lines of evidence indicate that T-cell responses influence the progression of atherosclerotic disease. Interferon-γ (IFN-γ)–producing T cells specific for lesional antigens, including oxidized LDLs and heat shock protein 60 (HSP60), may promote lesion development as well as plaque
Chiara, Buono, Hong, Pang, Yasushi, Uchida, Peter, Libby, Arlene H, Sharpe, Andrew H, Lichtman   +5 more
openaire   +2 more sources

The Role of Co-inhibitory Signaling Pathways in Transplantation and Tolerance

Frontiers in Immunology, 2012
Negative costimulatory molecules, acting through so-called inhibitory pathways, play a crucial role in the control of T cell responses. This negative ‘second signal’ opposes TCR activation and leads to downregulation of T cell proliferation and promotes ...
Martina M. McGrath, Nader eNajafian
doaj   +1 more source

High-throughput sorting of the highest producing cell via a transiently protein-anchored system. [PDF]

PLoS ONE, 2014
Developing a high-throughput method for the effecient selection of the highest producing cell is very important for the production of recombinant protein drugs.
Kuo-Hsiang Chuang, Yuan-Chin Hsieh, I-Shiuan Chiang, Chih-Hung Chuang, Chien-Han Kao, Ta-Chun Cheng, Yeng-Tseng Wang, Wen-Wei Lin, Bing-Mae Chen, Steve R Roffler, Ming-Yii Huang, Tian-Lu Cheng   +11 more
doaj   +1 more source

Clinical Insights Into Novel Immune Checkpoint Inhibitors

Frontiers in Pharmacology, 2021
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options ...
Jii Bum Lee, Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim   +3 more
doaj   +1 more source

Lack of B7-1/BB1 and B7-2/B70 expression on thyrocytes of patients with Graves' disease. Delivery of costimulatory signals from bystander professional antigen-presenting cells. [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1996
We have previously demonstrated that thyrocytes from patients with Graves' disease induce autologous peripheral blood T cell proliferation in response to soluble antigens, and a synergistic augmentation of T cell response by adding suboptimal numbers of monocytes.
N, Matsuoka, K, Eguchi, A, Kawakami, M, Tsuboi, H, Nakamura, H, Kimura, N, Ishikawa, K, Ito, S, Nagataki   +8 more
openaire   +3 more sources

A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells.

PLoS Computational Biology, 2021
The activation and differentiation of T-cells are mainly directly by their co-regulatory receptors. T lymphocyte-associated protein-4 (CTLA-4) and programed cell death-1 (PD-1) are two of the most important co-regulatory receptors.
Zhaoqian Su, Kalyani Dhusia, Yinghao Wu
doaj   +1 more source

Antitumor activity of the investigational B7-H3 antibody-drug conjugate, vobramitamab duocarmazine, in preclinical models of neuroblastoma

Journal for ImmunoTherapy of Cancer, 2023
Introduction B7-H3 is a potential target for pediatric cancers, including neuroblastoma (NB). Vobramitamab duocarmazine (also referred to as MGC018 and herein referred to as vobra duo) is an investigational duocarmycin-based antibody-drug conjugate (ADC)
Ezio Bonvini, Chiara Brignole, Enzo Calarco, Veronica Bensa, Elena Giusto, Patrizia Perri, Eleonora Ciampi, Maria Valeria Corrias, Simonetta Astigiano, Michele Cilli, Derik Loo, Fabio Pastorino, Mirco Ponzoni   +12 more
doaj   +1 more source

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. [PDF]

Proceedings of the National Academy of Sciences, 1994
Tolerance to peripheral antigens is thought to result from the inability of parenchymal tissue to stimulate T cells--an inability that is believed to relate to the lack of expression of the costimulatory signal(s) required for T-cell activation. To test this model, we generated transgenic mice expressing costimulatory molecule B7-1 on the B cells of ...
S, Guerder, D E, Picarella, P S, Linsley, R A, Flavell   +3 more
openaire   +2 more sources

Cell type specific regulation of immunological synapse dynamics by B7 ligand recognition

Frontiers in Immunology, 2016
B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen presenting cells and provide critical costimulatory or inhibitory input to T cells via their T-cell expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector and regulatory T
Joanna eBrzostek, Nicholas R.J. Gascoigne, Vasily eRybakin, Vasily eRybakin   +3 more
doaj   +1 more source

The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif. [PDF]

PLoS ONE, 2013
Membrane-tethered proteins (mammalian surface display) are increasingly being used for novel therapeutic and biotechnology applications. Maximizing surface expression of chimeric proteins on mammalian cells is important for these applications.
Yi-Chieh Lin, Bing-Mae Chen, Wei-Cheng Lu, Chien-I Su, Zeljko M Prijovich, Wen-Chuan Chung, Pei-Yu Wu, Kai-Chuan Chen, I-Chiao Lee, Ting-Yi Juan, Steve R Roffler   +10 more
doaj   +1 more source