Results 31 to 40 of about 30,012,915 (215)

A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells.

PLoS Computational Biology, 2021
The activation and differentiation of T-cells are mainly directly by their co-regulatory receptors. T lymphocyte-associated protein-4 (CTLA-4) and programed cell death-1 (PD-1) are two of the most important co-regulatory receptors.
Zhaoqian Su, Kalyani Dhusia, Yinghao Wu
doaj   +1 more source

B7-1 expression in human pancreatic cancer.

, 2019
(A) Frozen normal (n = 2) and human pancreatic tumor tissue (n = 2) was obtained from US Biomax (Rockville, MD, USA). Immunofluorescence confocal microscopy was performed on 3 slides from each of the two Normal and Pancreatic Cancer tissue specimens for ...
Edward B. Leof (7345010), Mi-Yeon Jung (7345007), Jeong-Han Kang (7345004)   +2 more
core   +1 more source

Cell type specific regulation of immunological synapse dynamics by B7 ligand recognition

Frontiers in Immunology, 2016
B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen presenting cells and provide critical costimulatory or inhibitory input to T cells via their T-cell expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector and regulatory T
Joanna eBrzostek, Nicholas R.J. Gascoigne, Vasily eRybakin, Vasily eRybakin   +3 more
doaj   +1 more source

Antitumor activity of the investigational B7-H3 antibody-drug conjugate, vobramitamab duocarmazine, in preclinical models of neuroblastoma

Journal for ImmunoTherapy of Cancer, 2023
Introduction B7-H3 is a potential target for pediatric cancers, including neuroblastoma (NB). Vobramitamab duocarmazine (also referred to as MGC018 and herein referred to as vobra duo) is an investigational duocarmycin-based antibody-drug conjugate (ADC)
Ezio Bonvini, Chiara Brignole, Enzo Calarco, Veronica Bensa, Elena Giusto, Patrizia Perri, Eleonora Ciampi, Maria Valeria Corrias, Simonetta Astigiano, Michele Cilli, Derik Loo, Fabio Pastorino, Mirco Ponzoni   +12 more
doaj   +1 more source

Abatacept in B7-1-positive proteinuric kidney disease [PDF]

, 2013
Abatacept (cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion protein [CTLA-4-Ig]) is a costimulatory inhibitor that targets B7-1 (CD80).
M. Amin Arnaout, M. H. Faridi, C. Faul, P. Fiorina, Behr, Daniel, Ciancio, Gaetano, S. Hakroush, J. Chang, Faridi, Mohd Hafeez, Faul, Christian, H. Chen, P. Mundel, G. Ciancio, G. W. Burke III, Fornoni, Alessia, Oh, Jun, L. Chen, J. Oh, Campbell, Kirk N, J. Sageshima, Hakroush, Samy, Mundel, Peter, D. Maiguel, Burke, 3rd, George W, D. Behr, K. N. Campbell, Fiorina, Paolo, Sageshima, Junichiro, A. Weins, Chang, Jer-Ming, Chen, Linda, C. Yu, Yu, Chih-Chuan, Weins, Astrid, Arnaout, M Amin, Greka, Anna, V. Gupta, Burke, George W, A. Fornoni, Maiguel, Dony, Gupta, Vineet, A. Greka, Chen, Hung-Chun   +42 more
core   +1 more source

The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif. [PDF]

PLoS ONE, 2013
Membrane-tethered proteins (mammalian surface display) are increasingly being used for novel therapeutic and biotechnology applications. Maximizing surface expression of chimeric proteins on mammalian cells is important for these applications.
Yi-Chieh Lin, Bing-Mae Chen, Wei-Cheng Lu, Chien-I Su, Zeljko M Prijovich, Wen-Chuan Chung, Pei-Yu Wu, Kai-Chuan Chen, I-Chiao Lee, Ting-Yi Juan, Steve R Roffler   +10 more
doaj   +1 more source

High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation

Journal for ImmunoTherapy of Cancer, 2019
Background B7-H3 and B7-H4 are highly expressed by many human malignancies making them attractive immunotherapeutic targets. However, their expression patterns and immune contexts in epithelial ovarian cancer have not been well characterized.
Heather L. MacGregor, Azin Sayad, Andrew Elia, Ben X. Wang, Sarah Rachel Katz, Patricia A. Shaw, Blaise A. Clarke, Sarah Q. Crome, Celine Robert-Tissot, Marcus Q. Bernardini, Linh T. Nguyen, Pamela S. Ohashi   +11 more
doaj   +1 more source

Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity [PDF]

, 1998
Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity.
Venaille, T.J., Lee, P.T., Stumbles, P.A., Pimm, C.L., Proksch, S., Holt, P.G., Thomas, J.A.   +6 more
core  

B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention

, 2023
B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-presenting cells, and tumor cells.
Dietrich Büsselberg, Mathews Samuel, Samson, Peter Kubatka, Varghese, Elizabeth, Shakibaei, Prof. Dr. Mehdi, Büsselberg, Dietrich, Aranka Brockmueller (11064675), Kubatka, Peter, Aranka Brockmueller, Mehdi Shakibaei (325455), Dietrich Büsselberg (11008857), Mehdi Shakibaei, Samson Mathews Samuel, Peter Kubatka (11008854), Elizabeth Varghese, Brockmueller, Aranka, Elizabeth Varghese (11008845), Samson Mathews Samuel (11008848)   +17 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source