Respiratory Research, 2011 Background Type II alveolar epithelial cells (AECII) are well known for their role in the innate immune system. More recently, it was proposed that they could play a role in the antigen presentation to T lymphocytes but contradictory results have been ...
Remmelink Myriam +5 more
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Frontiers in Immunology, 2022 Although immunotherapy has paved a new avenue for cancer treatment, inadequate immune response often executes suboptimal therapeutic effects. In general, an effective immune response undergoes presentation of antigen by antigen-presenting cells ...
Hu Chen +4 more
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Antigen - presentation by vascular endothelium : its role for CTL - mediated vascular injury [PDF]
, 2008 Background: EC express and present MHC class I restricted peptide antigens and due to the exposed position may be targeted by antigen-specific CTL. We wished to explore the type of vascular injury that is mediated by peptidespecific CTL in vivo when EC ...
Wang, Xueya
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B7 costimulation molecules encoded by replication-defective, vhs-deficient HSV-1 improve vaccine-induced protection against corneal disease. [PDF]
PLoS ONE, 2011 Herpes simplex virus 1 (HSV-1) causes herpes stromal keratitis (HSK), a sight-threatening disease of the cornea for which no vaccine exists. A replication-defective, HSV-1 prototype vaccine bearing deletions in the genes encoding ICP8 and the virion host
Jane E Schrimpf +4 more
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The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells [PDF]
, 2007 We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells.
MacDonald, Andrew +18 more
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B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation [PDF]
, 1997 Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and B7-2 failed to generate antigen-specific IgG1 and IgG2a responses and lacked germinal centers when immunized by a number of ...
Elizabeth A Tivol +29 more
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Structure and dimerization of a soluble form of B7-1 [PDF]
, 2000 B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on antigen-presenting cells. The binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates costimulatory and inhibitory signals in T cells, respectively.
Jones, E.Yvonne +23 more
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The Role of Co-inhibitory Signaling Pathways in Transplantation and Tolerance
Frontiers in Immunology, 2012 Negative costimulatory molecules, acting through so-called inhibitory pathways, play a crucial role in the control of T cell responses. This negative ‘second signal’ opposes TCR activation and leads to downregulation of T cell proliferation and promotes ...
Martina M. McGrath, Nader eNajafian
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High-throughput sorting of the highest producing cell via a transiently protein-anchored system. [PDF]
PLoS ONE, 2014 Developing a high-throughput method for the effecient selection of the highest producing cell is very important for the production of recombinant protein drugs.
Kuo-Hsiang Chuang +11 more
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Clinical Insights Into Novel Immune Checkpoint Inhibitors
Frontiers in Pharmacology, 2021 The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options ...
Jii Bum Lee +3 more
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