Results 41 to 50 of about 24,766,610 (239)

Immune checkpoint: The novel target for antitumor therapy

Genes and Diseases, 2021
Inhibitory checkpoint molecules include programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), cytotoxic T lymphocyte antigen-4 (CTLA-4), human endogenous retrovirus-H Long terminal repeat-associating 2 (HHLA2), B7 homolog 4 protein (B7 ...
Xianghu Jiang, Guohong Liu, Yirong Li, Yunbao Pan   +3 more
doaj   +1 more source

Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7- 1, B7-2 and CD28 [PDF]

International Immunology, 1998
Pertussis toxin (PT) is a major virulence factor of Bordetella pertussis which exerts a range of effects on the immune system, including the enhancement of IgE, IgA and IgG production, delayed-type hypersensitivity reactions, and the induction of experimental autoimmune diseases.
Ryan, Mark, McCarthy, Leone, Rappuoli, Rino, Mahon, Bernard P., Mills, Kingston H.G.   +4 more
openaire   +3 more sources

Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity [PDF]

, 1998
Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity.
Venaille, T.J., Lee, P.T., Stumbles, P.A., Pimm, C.L., Proksch, S., Holt, P.G., Thomas, J.A.   +6 more
core  

Role of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiation-induced immune changes

BMC Immunology, 2001
Background The present paper aims at studying the role of B7/CD28 interaction and related cytokine production in the immunological changes after exposure to different doses of ionizing radiation. Results The stimulatory effect of low dose radiation (LDR)
Sun Yi-Min, Liu Xiao-Dong, Jin Shun-Zi, Liu Shu-Zheng   +3 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

B7-1 expression in human pancreatic cancer.

, 2019
(A) Frozen normal (n = 2) and human pancreatic tumor tissue (n = 2) was obtained from US Biomax (Rockville, MD, USA). Immunofluorescence confocal microscopy was performed on 3 slides from each of the two Normal and Pancreatic Cancer tissue specimens for ...
Edward B. Leof (7345010), Mi-Yeon Jung (7345007), Jeong-Han Kang (7345004)   +2 more
core   +1 more source

B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention

, 2023
B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-presenting cells, and tumor cells.
Dietrich Büsselberg, Mathews Samuel, Samson, Peter Kubatka, Varghese, Elizabeth, Shakibaei, Prof. Dr. Mehdi, Büsselberg, Dietrich, Aranka Brockmueller (11064675), Kubatka, Peter, Aranka Brockmueller, Mehdi Shakibaei (325455), Dietrich Büsselberg (11008857), Mehdi Shakibaei, Samson Mathews Samuel, Peter Kubatka (11008854), Elizabeth Varghese, Brockmueller, Aranka, Elizabeth Varghese (11008845), Samson Mathews Samuel (11008848)   +17 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Reactive astrocytes in chronic active lesions of multiple sclerosis express co-stimulatory molecules B7-1 and B7-2

, 2003
Astrocytes in active lesions of multiple sclerosis (MS) express major histocompatibility (MHC) class 11 molecules, and may play an important role in the presentation of antigen to myelin-specific T cells.
Nadine Wilczak, Zeinstra, E, De Keyser, J, Wilczak, N, Esther Zeinstra, Jacques De Keyser   +5 more
core   +1 more source