Results 31 to 40 of about 24,766,610 (239)

B7-1/B7-2 Costimulation Regulates Plaque Antigen–Specific T-Cell Responses and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice [PDF]

Circulation, 2004
Background— Several lines of evidence indicate that T-cell responses influence the progression of atherosclerotic disease. Interferon-γ (IFN-γ)–producing T cells specific for lesional antigens, including oxidized LDLs and heat shock protein 60 (HSP60), may promote lesion development as well as plaque
Chiara, Buono, Hong, Pang, Yasushi, Uchida, Peter, Libby, Arlene H, Sharpe, Andrew H, Lichtman   +5 more
openaire   +2 more sources

Lack of B7-1/BB1 and B7-2/B70 expression on thyrocytes of patients with Graves' disease. Delivery of costimulatory signals from bystander professional antigen-presenting cells [PDF]

Journal of Clinical Endocrinology & Metabolism, 1996
We have previously demonstrated that thyrocytes from patients with Graves' disease induce autologous peripheral blood T cell proliferation in response to soluble antigens, and a synergistic augmentation of T cell response by adding suboptimal numbers of monocytes.
N, Matsuoka, K, Eguchi, A, Kawakami, M, Tsuboi, H, Nakamura, H, Kimura, N, Ishikawa, K, Ito, S, Nagataki   +8 more
openaire   +3 more sources

Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide

Clinical and Developmental Immunology, 2012
Background. Low expression or absence of dendritic cell (DC) surface B7 molecules can induce immune tolerance or hyporesponse. Whether DCs could induce indirect allogeneic-specific cross-tolerance or hyporesponse to recipient T cells remains unclear ...
Yu-Feng Yao, Yi-Ming Zhou, Jian-Bin Xiang, Xiao-Dong Gu, Duan Cai   +4 more
doaj   +1 more source

The ancestral haplotype markers HLA -A3 and B7 do not influence the likelihood of advanced hepatic fibrosis or cirrhosis in HFE hemochromatosis

Scientific Reports, 2023
Advanced hepatic fibrosis occurs in up to 25% of individuals with C282Y homozygous hemochromatosis. Our aim was to determine whether human leukocyte antigen (HLA)-A3 and B7 alleles act as genetic modifiers of the likelihood of advanced hepatic fibrosis ...
John K. Olynyk, Richard Grainger, Helen Currie, Louise E. Ramm, Grant A. Ramm   +4 more
doaj   +1 more source

Cell type specific regulation of immunological synapse dynamics by B7 ligand recognition

Frontiers in Immunology, 2016
B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen presenting cells and provide critical costimulatory or inhibitory input to T cells via their T-cell expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector and regulatory T
Joanna eBrzostek, Nicholas R.J. Gascoigne, Vasily eRybakin, Vasily eRybakin   +3 more
doaj   +1 more source

Prevention of CD8 T Cell Deletion during Chronic Viral Infection

Viruses, 2021
During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to this loss of function, CD8 T cells with the highest affinity for viral antigen can be physically
David G. Brooks, Antoinette Tishon, Michael B. A. Oldstone, Dorian B. McGavern   +3 more
doaj   +1 more source

Iris Pigment Epithelium Expressing CD86 (B7-2) Directly Suppresses T Cell Activation In Vitro via Binding to Cytotoxic T Lymphocyte–associated Antigen 4 [PDF]

The Journal of Experimental Medicine, 2003
A monolayer of pigment epithelium (PE) lines the iris PE (IPE), ciliary body PE, and retina PE of the inner eye, an immune-privileged site. These neural crest-derived epithelial cells participate in ocular immune privilege through poorly defined molecular mechanisms.
Sugita, Sunao, Streilein, J. Wayne
openaire   +2 more sources

The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]

, 2009
Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Loehe, Florian, Chaudry, Irshad H., Christian R. Walz, Christiane J. Bruns, Walz, Christian, Bruns, Christiane J., Irshad H. Chaudry, Eugen Faist, Faist, Eugen, Schneider, Christian P., Siegfried Zedler, Christian P. Schneider, Martin K. Angele, Markus Albertsmeier, Angele, Martin K., Zedler, Siegfried, Florian Loehe, Albertsmeier, Markus   +17 more
core   +1 more source

Suppression of Human T-Cell Responses to β-Cells by Activation of B7-H4 Pathway

Cell Transplantation, 2006
B7-H4, a recently described member of the B7 family of cosignal molecules, is thought to be involved in the regulation of cellular and humoral immune responses through receptors on activated T and B cells. Human islet cells express positive B7-H4 mRNA in
Dawei Ou, Xiaojie Wang, Daniel L. Metzger, Ziliang Ao, Paolo Pozzilli, Roger F. L. James, Lieping Chen, Garth L. Warnock   +7 more
doaj   +1 more source

Recombinant adenovirus-mediated gene transfer suppresses experimental arthritis

Reumatismo, 2001
Collagen Induced Arthritis (CIA) is a widely studied animal model to develop and test novel therapeutic approaches for treating Rheumatoid Arthritis (RA) in humans.
E. Quattrocchi, M. Feldmann
doaj   +1 more source