Results 11 to 20 of about 24,766,610 (239)

B7 homolog 3-targeted CAR-T cells secreting EGFR T-cell engagers for improved control of glioblastoma progression [PDF]

Molecular Biomedicine
Glioblastoma (GBM) is the most aggressive primary malignant brain tumor, and while chimeric antigen receptor-T (CAR-T) cell therapy has shown promise, its efficacy remains limited by antigen heterogeneity and immune escape.
Zongliang Zhang, Nian Yang, Hui Zeng, Yongdong Chen, Huaqing Lu, Long Xu, Zeng Wang, Guoqing Wang, Liangxue Zhou, Aiping Tong   +9 more
doaj   +2 more sources

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2 [PDF]

Immunity, 1995
Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils.
Liu, Yong-Jun, Barthélémy, Clarisse, Bouteiller, Odette De, Arpin, Christophe, Durand, Isabelle, Banchereau, Jacques   +5 more
openaire   +4 more sources

Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy [PDF]

Cell Reports Medicine
Summary: B7-H3 is a cell surface protein overexpressed in many solid tumors and an attractive target for chimeric antigen receptor (CAR) T cell therapy.
Pradip Bajgain, Yang Feng, Mariela Puebla, Meijie Tian, Kuo-Sheng Hsu, Jaewon Lee, GuoJun Yu, Liping Yang, Steven Seaman, Mary Beth Hilton, Karen Morris, Niza Borchin, Jennifer D. Tran, Riley D. Metcalfe, Dan Li, Mitchell Ho, James C. Cronk, Javed Khan, Anandani Nellan, Rosandra N. Kaplan, Brad St. Croix   +20 more
doaj   +2 more sources

Tissue Factor‐High Ovarian Clear Cell Carcinoma Shows Immune‐Cold Features and Preclinical Activity of Tisotumab Vedotin [PDF]

Cancer Science, EarlyView.
F3/TF‐high ovarian clear cell carcinoma exhibits an immune‐cold phenotype characterized by reduced immune‐cell fractions and attenuated cancer‐cell interferon programs, with frequent B7‐H4 co‐expression. Patient‐derived models show preclinical sensitivity to the TF‐directed antibody–drug conjugate tisotumab vedotin.
Yutaro Mori, Ryo Tamura, Kotaro Takahashi, Kaoru Yamawaki, Tatsuya Ishiguro, Teiichi Motoyama, Koji Okamoto, Kosuke Yoshihara   +7 more
wiley   +2 more sources

Preclinical development of ABL206, a novel bispecific antibody-drug conjugate targeting B7-H3 and ROR1 [PDF]

mAbs
Bispecific antibody-drug conjugates (BsADCs) represent a promising strategy to enhance tumor selectivity and overcome the limitations of monospecific ADCs. Here, we report the preclinical development of ABL206 (NEOK001), a novel BsADC targeting B7-H3 and
Jung A. Kwon, Suyoun Lee, Juhee Kim, Byeong Min Yoo, Hyeon Ji Park, Ilhwan Ryu, Junyoung Kim, JaeHyun Eom, Yong-Gyu Son, Donghoon Yeom, Byungje Sung, Myeonghan Yoo, Arim Seo, Jiseon Yoo, Jin Young Park, Jinwon Jung, Jinhyung Ahn, Weon-Kyoo You, Sang Hoon Lee, Min Ji Ko   +19 more
doaj   +2 more sources

Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions

Drug Design, Development and Therapy, 2014
Andreas O Doesch,1,* Li Zhao,1,* Christian A Gleissner,1 Mohammadreza Akhavanpoor,1 David Rohde,1 Deniz Okuyucu,1 Maani Hakimi,2 Thomas J Dengler,3 Hugo A Katus,1 Christian Erbel1 1Department of Cardiology, 2Department of Vascular Surgery, University of ...
Doesch AO, Zhao L, Gleissner CA, Akhavanpoor M, Rohde D, Okuyucu D, Hakimi M, Dengler TJ, Katus HA, Erbel C   +9 more
doaj   +1 more source

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core   +7 more sources

Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions. [PDF]

PLoS ONE, 2009
The human IgM B7-DC XAb protects mice from tumors in both therapeutic and prophylactic settings. Its mechanism of action is mediated by its binding to B7-DC/PD-L2 molecules on the surface of dendritic cells (DCs) to induce a multimolecular cap and ...
Suresh Radhakrishnan, Rosalyn Cabrera, Kristina M Bruns, Virginia P Van Keulen, Michael J Hansen, Sara J Felts, Larry R Pease   +6 more
doaj   +1 more source

CD154–CD40‐independent up‐regulation of B7‐2 on splenic antigen‐presenting cells and efficient T cell priming by staphylococcal enterotoxin A [PDF]

International Immunology, 2003
It has been demonstrated that in vivo T cell priming requires CD154-CD40 interaction, which is suggested to be critical in the induction of co-stimulatory activities on antigen-presenting cells (APC). In the current study, we demonstrate that in vivo administration of a high dose of a superantigen, staphylococcal enterotoxin A (SEA), could up-regulate ...
Koji, Eshima, Yongwon, Choi, Richard A, Flavell   +2 more
openaire   +2 more sources

CD86 (B7–2) antigen on B cells from atopic patients shows selective, antigen‐specific upregulation

Allergy, 1998
To determine whether B7 signals are associated with atopic responses in man, we assayed CD80 and CD86 expression on B cells and monocytes from atopic patients and controls. Peripheral blood mononuclear cells from 10 patients with perennial allergic rhinitis and from 10 normal subjects were cultured in the presence or absence of house‐dust‐mite antigen,
M, Nakada, K, Nishizaki, T, Yoshino, M, Okano, Y, Masuda, N, Ohta, T, Akagi   +6 more
openaire   +3 more sources