Results 21 to 30 of about 46,982 (194)

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) [PDF]

The Journal of Experimental Medicine, 1999
The costimulatory molecules B7-1 and B7-2 regulate T lymphocyte activation by delivering activating signals through CD28 and inhibitory signals through cytotoxic T lymphocyte–associated antigen 4 (CTLA-4). The importance of CTLA-4–mediated inhibition was demonstrated by the uncontrolled T cell activation and lymphoproliferative disease that develops in
D A, Mandelbrot, A J, McAdam, A H, Sharpe   +2 more
openaire   +2 more sources

Primary human mesothelioma cells express class II MHC, ICAM-1 and B7–2 and can present recall antigens to autologous blood lymphocytes [PDF]

International Journal of Cancer, 1998
Mesothelioma cells (MMc) are considered to be weakly immunogenic and the experimental approaches attempting to induce an immune response against these cells have been disappointing. Our aim was to investigate whether MMc possess the surface accessory molecules involved in antigen presentation and whether these cells are capable of presenting recall ...
Mutti L., Valle M. T., Balbi B., Orengo A. M., Lazzaro A., Alciato P., Gatti E., Betta P. G., Pozzi E.   +8 more
openaire   +3 more sources

Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes

Respiratory Research, 2011
Background Type II alveolar epithelial cells (AECII) are well known for their role in the innate immune system. More recently, it was proposed that they could play a role in the antigen presentation to T lymphocytes but contradictory results have been ...
Remmelink Myriam, Cappello Mattéo, Norrenberg Sarah, Dirix Violette, Corbière Véronique, Mascart Françoise   +5 more
doaj   +1 more source

Lack of B7-1/BB1 and B7-2/B70 expression on thyrocytes of patients with Graves' disease. Delivery of costimulatory signals from bystander professional antigen-presenting cells. [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1996
We have previously demonstrated that thyrocytes from patients with Graves' disease induce autologous peripheral blood T cell proliferation in response to soluble antigens, and a synergistic augmentation of T cell response by adding suboptimal numbers of monocytes.
N, Matsuoka, K, Eguchi, A, Kawakami, M, Tsuboi, H, Nakamura, H, Kimura, N, Ishikawa, K, Ito, S, Nagataki   +8 more
openaire   +3 more sources

B7-1/B7-2 Costimulation Regulates Plaque Antigen–Specific T-Cell Responses and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice [PDF]

Circulation, 2004
Background— Several lines of evidence indicate that T-cell responses influence the progression of atherosclerotic disease. Interferon-γ (IFN-γ)–producing T cells specific for lesional antigens, including oxidized LDLs and heat shock protein 60 (HSP60), may promote lesion development as well as plaque
Chiara, Buono, Hong, Pang, Yasushi, Uchida, Peter, Libby, Arlene H, Sharpe, Andrew H, Lichtman   +5 more
openaire   +2 more sources

Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide

Clinical and Developmental Immunology, 2012
Background. Low expression or absence of dendritic cell (DC) surface B7 molecules can induce immune tolerance or hyporesponse. Whether DCs could induce indirect allogeneic-specific cross-tolerance or hyporesponse to recipient T cells remains unclear ...
Yu-Feng Yao, Yi-Ming Zhou, Jian-Bin Xiang, Xiao-Dong Gu, Duan Cai   +4 more
doaj   +1 more source

The ancestral haplotype markers HLA -A3 and B7 do not influence the likelihood of advanced hepatic fibrosis or cirrhosis in HFE hemochromatosis

Scientific Reports, 2023
Advanced hepatic fibrosis occurs in up to 25% of individuals with C282Y homozygous hemochromatosis. Our aim was to determine whether human leukocyte antigen (HLA)-A3 and B7 alleles act as genetic modifiers of the likelihood of advanced hepatic fibrosis ...
John K. Olynyk, Richard Grainger, Helen Currie, Louise E. Ramm, Grant A. Ramm   +4 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Prevention of CD8 T Cell Deletion during Chronic Viral Infection

Viruses, 2021
During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to this loss of function, CD8 T cells with the highest affinity for viral antigen can be physically
David G. Brooks, Antoinette Tishon, Michael B. A. Oldstone, Dorian B. McGavern   +3 more
doaj   +1 more source

Cell type specific regulation of immunological synapse dynamics by B7 ligand recognition

Frontiers in Immunology, 2016
B7 proteins CD80 (B7-1) and CD86 (B7-2) are expressed on most antigen presenting cells and provide critical costimulatory or inhibitory input to T cells via their T-cell expressed receptors: CD28 and CTLA-4. CD28 is expressed on effector and regulatory T
Joanna eBrzostek, Nicholas R.J. Gascoigne, Vasily eRybakin, Vasily eRybakin   +3 more
doaj   +1 more source