Results 141 to 150 of about 385,065 (234)

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. [PDF]

, 1992
Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response.
Azuma, M, Buck, D, Cayabyab, M, Lanier, LL, Phillips, JH   +4 more
core   +1 more source

Computational Validation of Multi‐Epitope mRNA Vaccine Targeting Streptococcus anginosus Surface Protein (TMPC) as an Effective Alternative Treatment to Reduce Gastric Cancer

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Design process for messenger RNA vaccines. Candidate proteins are initially screened using immunoinformatics, after which selected epitopes are assembled into a multi‐epitope vaccine. The vaccine construct was evaluated through molecular docking, molecular dynamics simulations, and in silico immune simulations, followed by population coverage analysis ...
Fei Zhu, Yuying Luo, Ziyou Zhou, Rongliu Qin, Shiyang Ma, Yizhong Xu, Jie Chen, Pinhua Pan   +7 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

Immunology, Volume 177, Issue 2, Page 317-328, February 2026.
LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta, Shi‐Chuen Miaw, Tse‐Ching Chen, Chia‐Shiang Chang, Yu‐Lin Huang, Yung‐Chang Lin, Chun‐Yen Lin, Ching‐Tai Huang   +7 more
wiley   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

HLA Class II Alleles Are Associated With Anti‐Drug Antibodies in Ulcerative Colitis Patients Treated With Etrolizumab

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT Patients treated with etrolizumab, a monoclonal antibody drug for ulcerative colitis, often develop anti‐drug antibodies (ADA) and neutralising antibodies (NAb). To investigate genetic risk factors, we evaluated associations between HLA alleles and ADA/NAb development. HLA‐DQB1*06:03 demonstrated the most significant association with both ADA (
Ashis Saha, Mark I. McCarthy, Saloumeh K. Fischer, Gizette Sperinde, Christian Hammer   +4 more
wiley   +1 more source

Advances in T cell–based immunotherapy for osteosarcoma

Frontiers in Immunology
Osteosarcoma, the most prevalent primary malignant bone tumor in children and adolescents, remains a formidable clinical challenge due to its high metastatic potential and limited therapeutic progress over the past three decades.
Kun Zhang, Zheng Wang, Jiaqi He, Liuru Lu, Wenshu Wang, Aiwei Yang, Huayi Xie, Linhui Huang, Yuying Huang, Ke Zhang, Mingyang Jiang, Ruqiong Wei   +11 more
doaj   +1 more source

Expression and immmunogenicity of HLA-B27 in high-transfection recipient P815: [PDF]

, 1989
Kuon, W., Riethmüller, Gert, Thureau, S. R., Weiss, Elisabeth H., Wildner, G.   +4 more
core   +1 more source

Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines

Nature Communications
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell immunity against current and emerging SARS-CoV-2 variants. Precise identification of conserved T-cell epitopes is critical for designing effective vaccines.
Kevin A. Kovalchik, David J. Hamelin, Peter Kubiniok, Benoîte Bourdin, Fatima Mostefai, Raphaël Poujol, Bastien Paré, Shawn M. Simpson, John Sidney, Éric Bonneil, Mathieu Courcelles, Sunil Kumar Saini, Mohammad Shahbazy, Saketh Kapoor, Vigneshwar Rajesh, Maya Weitzen, Jean-Christophe Grenier, Bayrem Gharsallaoui, Loïze Maréchal, Zhaoguan Wu, Christopher Savoie, Alessandro Sette, Pierre Thibault, Isabelle Sirois, Martin A. Smith, Hélène Decaluwe, Julie G. Hussin, Mathieu Lavallée-Adam, Etienne Caron   +28 more
doaj   +1 more source

Organization, sequence and expression of the HLA-B27 gene [PDF]

, 1985
Doerner, C., Kuon, W., Lang, M., Riethmüller, Gert, Weiss, Elisabeth H.   +4 more
core   +1 more source