Results 121 to 130 of about 343,349 (228)

Structural Determination of a Human IgE Epitope on Major Birch Allergen Bet v 1

Allergy, EarlyView.
Andrea O'Malley, Brooke T. Borders, Jeffrey M. Wilson, Scott A. Smith, Maksymilian Chruszcz   +4 more
wiley   +1 more source

BACH2 alleviates immune checkpoint inhibitors‐induced cardiac pyroptosis via transcriptionally promoting GRSF1

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Immune checkpoint inhibitors cause elevated cardiac injuries in humans and mice. ICIs cause myocyte pyroptosis and cardiotoxicity, not via the adaptive immune system BACH2 ameliorates ICIs‐induced pyroptosis through transcriptionally promoting GRSF1. Lipoic acid, as a transcriptional inducer of BACH2, suppresses ICIs‐induced cardiotoxicity.
Mengying Cao, Zilong Liu, Di Zhao, Hongyuan Zhang, Xinjie He, Wenhao Wang, Xiaolin Wang, Cheng Yang, Pan Gao, Yunzeng Zou   +9 more
wiley   +1 more source

Model‐Informed Abatacept Dose Recommendation in Pediatric Patients With Acute Graft Versus Host Disease

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract This study uses a population pharmacokinetic (PPK) approach to provide abatacept dosing recommendations in pediatric patients 2 to < 6 years of age receiving unrelated donor hematopoietic stem cell transplantation (HSCT) due to hematologic malignancies (HMs), for the prophylaxis of acute graft‐versus‐host disease (aGVHD).
Rui Zhong, Kelly Maxwell, Julie Passarell, Bindu Murthy, Urvi Aras, Daphne Williams   +5 more
wiley   +1 more source

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies [PDF]

, 2009
The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs, Ejrnaes, Mette, Herrath, Matthias G. von   +2 more
core  

The Effects of Soy Protein–Rich Meals on Muscle Health of Older Adults Are Linked to Gut Microbiome Modifications

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenia is characterized by accelerated muscle mass and function loss in older adults. The role of nutritional interventions in sarcopenia is uncertain. This study investigates whether a soy protein–rich diet can enhance muscle health in older adults via gut microbiota changes.
Xiaorong Wu, Kevin Junliang Lim, Yiwei Ma, Jie Gu, Yuanrong Jiang, Liying Zhu, Yanqiu Chen, Jianqing Sun   +7 more
wiley   +1 more source

The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Dendrogenin A stimulates, via LXRβ, the expression and activity of enzymes responsible for the biosynthesis of the phospholipid BMP. BMP is a key determinant of the antitumour immunogenicity of exosomes secreted by DDA‐treated melanoma and triple‐negative breast cancer cells and enhances mouse survival and anti‐PD‐1 therapy in melanoma.
Julio Buñay, Michel Record, Philippe de Medina, Silia Ayadi, Laly Pucheu, Céline Colacios, Bruno Ségui, Marcus Höring, Gerhard Liebisch, Hélène Martin, Marc Poirot, Sandrine Silvente‐Poirot   +11 more
wiley   +1 more source

VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses

Journal of Neuroinflammation
Although B7 family immune checkpoint molecules such as PD-L1/PD-1 have improved the treatment of cancer and autoimmune diseases, more such molecules are still needed to expand therapeutic options.
Xianbin Wang, Rong Hu, Kezhu Chen, Keke He, Yuandi Li, Jie Gao, Yishen Tian, Guangshi Du, Zuli Wang, Youbo Zhao, Laijun Lai, Min Su   +11 more
doaj   +1 more source

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. [PDF]

, 1992
Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response.
Azuma, M, Buck, D, Cayabyab, M, Lanier, LL, Phillips, JH   +4 more
core   +1 more source

Computational Validation of Multi‐Epitope mRNA Vaccine Targeting Streptococcus anginosus Surface Protein (TMPC) as an Effective Alternative Treatment to Reduce Gastric Cancer

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Design process for messenger RNA vaccines. Candidate proteins are initially screened using immunoinformatics, after which selected epitopes are assembled into a multi‐epitope vaccine. The vaccine construct was evaluated through molecular docking, molecular dynamics simulations, and in silico immune simulations, followed by population coverage analysis ...
Fei Zhu, Yuying Luo, Ziyou Zhou, Rongliu Qin, Shiyang Ma, Yizhong Xu, Jie Chen, Pinhua Pan   +7 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source