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A molecular and biological study of the role of B7-1 and B7-2 antigens in the immunostimulatory properties of myeloid leukaemic cells

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CD86 (B7–2) antigen on B cells from atopic patients shows selective, antigen‐specific upregulation

Allergy, 1998
To determine whether B7 signals are associated with atopic responses in man, we assayed CD80 and CD86 expression on B cells and monocytes from atopic patients and controls. Peripheral blood mononuclear cells from 10 patients with perennial allergic rhinitis and from 10 normal subjects were cultured in the presence or absence of house‐dust‐mite antigen,
M, Nakada, K, Nishizaki, T, Yoshino, M, Okano, Y, Masuda, N, Ohta, T, Akagi   +6 more
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CD86 (B7-2) Can Function to Drive MHC-Restricted Antigen-Specific CTL Responses In Vivo

The Journal of Immunology, 1999
AbstractActivation of T cells requires both TCR-specific ligation by direct contact with peptide Ag-MHC complexes and coligation of the B7 family of ligands through CD28/CTLA-4 on the T cell surface. We recently reported that coadministration of CD86 cDNA along with DNA encoding HIV-1 Ags i.m. dramatically increased Ag-specific CTL responses.
M G, Agadjanyan, J J, Kim, N, Trivedi, D M, Wilson, B, Monzavi-Karbassi, L D, Morrison, L K, Nottingham, T, Dentchev, A, Tsai, K, Dang, A A, Chalian, M A, Maldonado, W V, Williams, D B, Weiner   +13 more
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Association of co-stimulatory human B-lymphocyte antigen B7-2 (CD86) gene polymorphism with colorectal cancer risk.

Gastroenterology and hepatology from bed to bench, 2013
This study investigated the role of CD86 +237 G/C polymorphism in intensifying the risk of CRC development.Colorectal cancer (CRC) is a multi-factorial diseases. Genetic background could affect the susceptibility of individuals to CRC development. CD86 is a co-stimulatory factor on antigen-presenting cells that plays key roles in several cancer related
Azimzadeh, Pedram, Romani, Sara, Mirtalebi, Hanieh, Fatemi, Seyed Reza, Kazemian, Shabnam, Khanyaghma, Mahsa, Mohebbi, Seyed Reza   +6 more
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IL-12 Reverses Established Antigen-Specific Tolerance of Contact Sensitivity by Affecting Costimulatory Molecules B7-1 (CD80) and B7-2 (CD86)

The Journal of Immunology, 1998
AbstractCutaneous painting with reactive haptens induces contact sensitivity (CS) responses that are in vivo examples of T cell immunity. In contrast, high dose i.v. administration of the hapten can induce tolerance. We investigated the effect of IL-12 on reversal of this tolerance and attempted to determine in vitro the mechanism of this reversing ...
H, Ushio, R F, Tsuji, M, Szczepanik, K, Kawamoto, H, Matsuda, P W, Askenase   +5 more
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Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)

Immunogenetics, 1995
The generation of an antigen-specific T-cell response requires that the T lymphocyte receive two signals from the antigen presenting cell. The specificity of this response is provided by antigen presented to the T lymphocyte and involves stimulation of the T lymphocyte via the T-cell receptor (TCR)/CD3 complex.
C L, Jellis, S S, Wang, P, Rennert, F, Borriello, A H, Sharpe, N R, Green, G S, Gray   +6 more
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Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

The Journal of Immunology, 1994
Abstract Ag-pulsed B cells are potent APCs, in part, because of the ability of the Ig receptor to mediate rapid and specific Ag uptake. However, it is also known that full T cell activation requires signals delivered by costimulatory molecules, which naive B cells seem to lack. This study examines the effect Ig receptor engagement has on
D J, Lenschow, A I, Sperling, M P, Cooke, G, Freeman, L, Rhee, D C, Decker, G, Gray, L M, Nadler, C C, Goodnow, J A, Bluestone   +9 more
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Importance of B7-1-Expressing Host Antigen-Presenting Cells for the Eradication of B7-2 Transfected P815 Tumor Cells

The Journal of Immunology, 1998
AbstractWe have previously shown that B7-2 (CD86)-transfected P815 tumor cells elicit tumor-eradicating immunity that leads to the regression of the B7-2+ P815 tumor after transient growth in normal DBA/2 mice. Here, we show that both the B7-2 and B7-1 (CD80) molecules contribute to the eradication of B7-2+ P815 tumors as treatment of the mice with ...
R N, La Motte, A H, Sharpe, J A, Bluestone, M B, Mokyr   +3 more
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