Results 101 to 110 of about 12,335 (206)

Alterations of immune response of non-small lung cancer with azacytidine [PDF]

, 2013
Innovative therapies are needed for advanced Non-Small Cell Lung Cancer (NSCLC). We have undertaken a genomics based, hypothesis driving, approach to query an emerging potential that epigenetic therapy may sensitize to immune checkpoint therapy targeting
Baylin, Stephen B, Brahmer, Julie R, Brock, Malcolm V, Carvajal, Richard D, De Meyer, Tim, Du, Zhengzong, Easton, Keith, Easwaran, Hariharan, Jones, Peter A, Juergens, Rosalyn A, Koch, Alexander, Laird, Peter W, Mohammad, Helai P, Pardoll, Drew, Parsana, Princy, Rodgers, Kristen, Rudin, Charles M, Taube, Janis M, Topalian, Suzanne L, Tsai, Salina, Tykodi, Scott S, Van Criekinge, Wim, Vendetti, Frank, Wang, Wei, Weisenberger, Daniel J, Wrangle, John, Yen, Ray-Whay, Zahnow, Cynthia A   +27 more
core   +1 more source

The Anionically All‐Boron‐Based Anti‐Perovskites Cs3[BH4][B12H12] and Cs3[BF4][B12H12]

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
The anionically all‐boron‐based colorless anti‐perovskites Cs3[BH4][B12H12] and Cs3[BF4][B12H12] can be obtained by isothermal evaporation from aqueous solutions of the underlying pseudo‐binary components Cs2[B12H12] and Cs[BH4] or Cs[BF4]. At ambient conditions, Cs3[BH4][B12H12] crystallizes trigonally (R3¯$\overline{3}$m) and transforms reversibly ...
Ioannis Tiritiris, Rouzbeh Aghaei Hakkak, Maryam Ranjbar, Thomas Schleid   +3 more
wiley   +1 more source

Preclinical evaluation of antigen-sensitive B7-H3-targeting nanobody-based CAR-T cells in glioblastoma cautions for on-target, off-tumor toxicity

Journal for ImmunoTherapy of Cancer
Background Glioblastoma is the most common lethal primary brain tumor, urging evaluation of new treatment options. Chimeric antigen receptor (CAR)-T cells targeting B7 homolog 3 (B7-H3) are promising because of the overexpression of B7-H3 on glioblastoma
Bart Neyns, Sandra Tuyaerts, Ivan Van Riet, Karine Breckpot, Fien Meeus, Cyprine Neba Funeh, Robin Maximilian Awad, Katty Zeven, Dorien Autaers, Ann De Becker, Cleo Goyvaerts, Nick Devoogdt, Yannick De Vlaeminck   +12 more
doaj   +1 more source

Different expression of B7-H3 in the caput, corpus, and cauda of the epididymis in mouse

BMC Urology, 2017
Background B7-H3, a member of the B7 family of the Ig superfamily of proteins, has been detected in the epididymis, which is a storage organ related to sperm maturation.
Kai Li, Xuedong Wei, Guangbo Zhang, Miao Li, Xuefeng Zhang, Chenhao Zhou, Jianquan Hou, Hexing Yuan   +7 more
doaj   +1 more source

Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

npj Precision Oncology, 2022
B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target.
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang   +13 more
doaj   +1 more source

Antitumor effects of intracranial injection of B7-H3-targeted Car-T and Car-Nk cells in a patient-derived glioblastoma xenograft model [PDF]

The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: https://doi.org/10.1007/s00262-024-03808-0.Background: Glioblastoma multiforme (GBM) is the most lethal primary brain ...
Hirayama, Ryuichi, Hosen, Naoki, Ikeda, Syunya, Imai, Chihaya, Kagawa, Naoki, Kijima, Noriyuki, Kishima, Haruhiko, Kuroda, Hideki, Murakami, Koki, Nakagawa, Kanji, Nakagawa, Tomoyoshi, Okita, Yoshiko, Tachi, Tetsuro, Utsugi, Reina, Yaga, Moto   +14 more
core   +1 more source

Sarcoma immunotherapy. [PDF]

, 2011
Much of our knowledge regarding cancer immunotherapy has been derived from sarcoma models. However, translation of preclinical findings to bedside success has been limited in this disease, though several intriguing clinical studies hint at the potential ...
Gouw, Launce G, Jones, Kevin B, Randall, R Lor, Sharma, Sunil   +3 more
core   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source