Results 121 to 130 of about 12,335 (206)

Functional Analysis of B7-H3 in Colonic Carcinoma Cells

Asian Pacific Journal of Cancer Prevention, 2012
B7-H3 is a newly discovered member of the B7/CD28 superfamily which functions as an important T-cell immune molecule. It has been reported recently that B7-H3 is highly expressed in many cancer cells, the data indicating that it may be a regulation factor contributing to tumor-resistance.
Peng, Lu, Rong, Liu, Er-Min, Ma, Tie-Jian, Yang, Jia-Lin, Liu   +4 more
openaire   +3 more sources

Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

Frontiers in Pharmacology, 2020
Chimeric antigen receptor (CAR)-modified natural killer (NK) cell therapy represents a kind of promising anti-cancer treatment because CAR renders NK cells activation and recognition specificity toward tumor cells.
Shuo Yang, Shuo Yang, Bihui Cao, Guangyu Zhou, Guangyu Zhou, Lipeng Zhu, Lipeng Zhu, Lu Wang, Li Zhang, Hang Fai Kwok, Hang Fai Kwok, Zhenfeng Zhang, Qi Zhao, Qi Zhao   +13 more
doaj   +1 more source

MicroRNAs miR-29a, miR-29b, and miR-29c as Novel Regulators of NK-cell Immune Response in Neuroblastoma [PDF]

, 2023
Background: Neuroblastoma is a challenging cancer to treat in pediatric patients. Despite intense treatment regimens, the prognosis for high-risk pediatric neuroblastoma patients remains poor, with less than 40% survival. Significance of the Problem: One
Pathania, Anup
core   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

B7-H3 as a Therapeutic Target in Advanced Prostate Cancer [PDF]

\ua9 2022 The Author(s). Background: B7-H3 is a cell surface immunomodulatory glycoprotein overexpressed in prostate cancers (PCs). Understanding its longitudinal expression at emergence of castration resistance and association with tumour genomics are ...
Alimonti A, Baker C, Bertan C, Bogdan D, Bressan S, Buroni L, Cali B, Carreira S, Chandran K, Crespo M, de Bono JS, Drake CG, Fenor de la Maza MD, Ferreira A, Figueiredo I, Gallagher L, Guo C, Gurel B, Hawley JE, Miranda S, Neeb A, Nguyen AHT, Obradovic A, Rekowski J, Rescigno P, Riisnaes R, Seed G, Sharp A, Shen MM, Tunariu N, Welti J, Westaby D, Yuan W   +32 more
core  

B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres [PDF]

, 2019
Background: The dismal survival of glioblastoma (GBM) patients urgently calls for the development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy, but preclinical and clinical studies in GBM have shown that ...
Damrauer, J.S., Di Ianni, N., Dotti, G., Du, H., Dunn, D.E., Edwards, D.S., Ferrone, S., Finocchiaro, G., Floyd, S.R., Hudson, H., Musio, S., Nehama, D., Park, J.J.H., Patané, M., Pellegatta, S., Pollo, B., Savoldo, B.   +16 more
core   +2 more sources

Development of a Novel Extracellular Vesicle‐Based Biomarker Approach for Pediatric High‐Grade Glioma

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Pediatric high‐grade gliomas (pHGGs) account for 20% of childhood brain tumours and are associated with poor survival. Currently, pHGG detection relies on MRI, a costly and time‐consuming procedure. Extracellular vesicles (EVs) carry molecular markers indicative of their cellular origin and can be isolated from various biofluids, offering an ...
Adriana Fernandez Garcia, Poorvi Iyer, Pablo Ashi, Ibukunoluwa Tella, Vennela Sangaraboina, Dhruv Bhagat, Chelva Janarthanam, Alejandra Bargues‐Carot, Anumantha G. Kanthasamy, Thomas Spoerer, Morgane E. Golan, Steven L. Stice, Kosuke Funato   +12 more
wiley   +1 more source

B7-H3 overexpression in pancreatic cancer promotes tumor progression

International Journal of Molecular Medicine, 2012
B7-H3, a member of the B7-family molecules, plays an important role in adaptive immune responses. In addition, B7-H3 is also expressed in several types of human cancers and is correlated with the poor outcome of cancer patients. However, its exact role in cancer is not known.
ZHAO, XIN, LI, DE-CHUN, ZHU, XIN-GUO, GAN, WEN-JUAN, LI, ZHI, XIONG, FENG, ZHANG, ZI-XIANG, ZHANG, GUANG-BO, ZHANG, XUE-GUANG, ZHAO, HUA   +9 more
openaire   +3 more sources

B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheresResearch in context

EBioMedicine, 2019
Background: The dismal survival of glioblastoma (GBM) patients urgently calls for the development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy, but preclinical and clinical studies in GBM have shown that ...
Dean Nehama, Natalia Di Ianni, Silvia Musio, Hongwei Du, Monica Patané, Bianca Pollo, Gaetano Finocchiaro, James J.H. Park, Denise E. Dunn, Drake S. Edwards, Jeffrey S. Damrauer, Hannah Hudson, Scott R. Floyd, Soldano Ferrone, Barbara Savoldo, Serena Pellegatta, Gianpietro Dotti   +16 more
doaj   +1 more source

Computational Validation of Multi‐Epitope mRNA Vaccine Targeting Streptococcus anginosus Surface Protein (TMPC) as an Effective Alternative Treatment to Reduce Gastric Cancer

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Design process for messenger RNA vaccines. Candidate proteins are initially screened using immunoinformatics, after which selected epitopes are assembled into a multi‐epitope vaccine. The vaccine construct was evaluated through molecular docking, molecular dynamics simulations, and in silico immune simulations, followed by population coverage analysis ...
Fei Zhu, Yuying Luo, Ziyou Zhou, Rongliu Qin, Shiyang Ma, Yizhong Xu, Jie Chen, Pinhua Pan   +7 more
wiley   +1 more source