Results 131 to 140 of about 12,335 (206)
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Public Administration and Development, Volume 46, Issue 1, Page 7-20, February 2026.ABSTRACT This study aims to fill the research gap within the principal‐agent framework by investigating the effect of local government (LG) institutional characteristics on the online accessibility of local public enterprises' (LPEs) financial statements.
Ray Ferza, Don S. Lee
wiley +1 more source
B7-H3 promotes gastric cancer cell migration and invasion
Oncotarget, 2017 B7-H3 (B7 homologue 3, CD276) is a member of the B7 immunoregulatory family and promotes tumor progression. The present study demonstrated that B7-H3 promotes gastric cancer cell migration and invasion. shRNA-mediated B7-H3 silencing in the N87 gastric cancer cell line suppressed cell migration and invasion in vitro and in vivo; downregulated ...
Li, Yecheng +8 more
openaire +3 more sources
T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy
Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri +7 more
wiley +1 more source
B7‐H3 promotes nasopharyngeal carcinoma progression by regulating CD8+ T cell exhaustion
Immunity, Inflammation and DiseaseBackground B7‐H3 protein is an important regulator of the adaptive immune response in human tumorigenesis. 4‐1BB is a co‐stimulatory receptor expressed on activated CD8+ T cells, and regulates T cell immunity.
Zhaoen Ma +9 more
doaj +1 more source
B7-H3 Inhibitors in Oncology Clinical Trials: A Review
Journal of Immunotherapy and Precision OncologyABSTRACT B7-H3 is a transmembrane receptor highly prevalent on malignant cells and plays an important role in adaptive immunity that is not fully elucidated. Targeted B7-H3 inhibitors, including antibody-drug conjugates, radioimmunotherapy, and monoclonal antibodies, are a new class of antineoplastic agents showing promising preliminary ...
Kavanya Feustel +2 more
openaire +3 more sources
CAR-T CELL THERAPY FOR TRIPLE-NEGATIVE BREAST CANCER: PRECLINICAL INSIGHTS FOR IMMUNOTHERAPY OPTIMIZATION IN OBESITY [PDF]
Immunotherapy is a type of treatment that harnesses a patient’s immune system to target diseases like cancer. Chimeric antigen receptor (CAR)-T cell therapy relies on T cells engineered to target antigens expressed on cancer cells and has radically ...
Malian, Hannah
core +2 more sources
Expression and clinical significance of B7-H3 in oral tongue squamous cell carcinoma
Kouqiang hemian waike zazhi[Objective:] To investigate the expression, clinical significance, and prognostic relevance of B7 homolog 3 (B7‑H3) in oral tongue squamous cell carcinoma (OTSCC).
CHEN Yuanyuan +4 more
doaj +1 more source
iScienceSummary: B7-H3, an immune checkpoint molecule, is prominently overexpressed in various solid tumors, correlating with poor clinical outcomes. Despite its critical role in promoting tumorigenesis, metastasis, and immune evasion, the regulatory mechanisms ...
Yu Ri Seo +6 more
doaj +1 more source
516 CD47 x B7-H3 bispecific antibody offers a new strategy for treating B7-H3+/CD47+ tumors
Regular and Young Investigator Award Abstracts, 2023 Xinhua Wang +5 more
openaire +2 more sources