Results 191 to 200 of about 12,335 (206)

Frequent B7-H3 overexpression in craniopharyngioma

Biochemical and Biophysical Research Communications, 2019
Craniopharyngiomas (CPs) are uncommon intracranial benign neoplasms that located in sellar/parasellar region with clinically challenging. B7-H3 is an immune checkpoint molecule highly expressed in many malignant tumors. In this study, we analyzed whether B7-H3 is expressed in 44 CPs samples (adamantinomatous CPs: n = 30 and papillary CPs: n = 14), and ...
Caili, Chen, Yuelong, Wang, Kunhong, Zhong, Caiying, Jiang, Lian, Wang, Zhu, Yuan, Chunlai, Nie, Jianguo, Xu, Gang, Guo, Liangxue, Zhou, Mu, Yang, Aiping, Tong   +11 more
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B7‐H3 overexpression in oral cancer

Oral Diseases, 2016
Abstract In a recent study published in Proceedings of the National Academy of Sciences of the United States of America, Chen and collaborators (2015), aiming to discover predictive markers with impact on treatment and survival of patients with oral squamous cell carcinoma (OSCC), described an important role of the transmembrane receptor B7 homolog 3 ...
R D, Coletta, Afp, Leme
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Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma

Cancer Biomarkers, 2022
BACKGROUND and OBJECTIVE: Gastric adenocarcinoma (GAC) is one of the most common malignancies. Increasing data have indicated a correlation between soluble B7-H3 (sB7-H3) levels and tumor malignancies. In this study, we aim to investigate the level of soluble B7-H3 in serum of GAC patients.
Lili, Huang, Yan, Zhou, Qiuwei, Sun, Lei, Cao, Xueguang, Zhang   +4 more
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B7-H3 Promoted Sperm Motility in Humans

Urology, 2014
To determine whether seminal B7-H3 levels are correlated to semen parameters and affect human sperm functions.A total of 83 healthy donors of proven fertility (aged 22-37 years) and 176 infertile men (aged 21-38 years) were recruited. Computer-assisted semen analysis and enzyme-linked immunosorbent assay were used to assess the correlations between ...
Xuedong, Wei, Zigang, Li, Guangbo, Zhang, Hexing, Yuan, Jingxing, Lv, Yufeng, Jiang, Wei, Zhang, Yuhua, Huang, Jianquan, Hou   +8 more
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B7-H3 co-stimulates T-cell immune responses via the B7-H3 receptor ligation (88.21)

The Journal of Immunology, 2007
Abstract B7-H3 is a new member of B7 family molecules and is widely expressed on various types of tissue and tumor cells as well as immune cells, such as macrophages and dendritic cells. It was suggested that B7-H3 binds a putative counter-receptor on activated T cells that is distinct from the already identified CD28 family molecules ...
Masaaki Hashiguchi, Hiroko Kobori, Patcharee Ritprajak, Jinhua Piao, Miyuki Azuma   +4 more
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B7-H3 Immune Checkpoint Protein in Human Cancer

Current Medicinal Chemistry, 2020
B7-H3 belongs to the B7 family of immune checkpoint proteins, which are important regulators of the adaptive immune response and emerging key players in human cancer. B7-H3 is a transmembrane protein expressed on the surface of tumor cells, antigen presenting cells, natural killer cells, tumor endothelial cells, but can also be present in intra- and ...
Karine, Flem-Karlsen, Øystein, Fodstad, Caroline E, Nunes-Xavier   +2 more
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B7-H3 expression in children with asthma exacerbation

Allergy and Asthma Proceedings, 2015
Recent studies have shown that B7-H3, a recently identified B7 family member, plays a critical role in the development of asthma.This study is to explore the expression of B7-H3 in children with asthma exacerbation.Twenty-one Chinese children with asthma exacerbation as well as 18 nonasthmatic control Chinese children were enrolled.
Zhengrong, Chen, Guangbo, Zhang, Yuqing, Wang, Yongdong, Yan, Canhong, Zhu, Li, Huang, Meijuan, Wang, Chuangli, Hao, Wei, Ji   +8 more
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B7-H3 promotes angiogenesis in rheumatoid arthritis

Molecular Immunology
The primary pathological changes of rheumatoid arthritis (RA) include chronic synovial inflammation, bone destruction, and aggressive pannus formation on cartilage, in which angiogenesis plays a critical role. B7-H3, an important immune checkpoint molecule, represents a novel target in tumor therapy and plays a significant role in the pathogenesis of ...
Jie, Yang, Jian, Xiong, Yuling, Sun, Li, Gu, Yachun, Chen, Yundi, Guo, Cuiping, Liu, Jing, Sun   +7 more
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B7-H3 and its role in bone cancers

Pathology - Research and Practice, 2019
Most bone cancers have a high risk of metastasis, recurrence, and poor prognosis. Although conventional treatments are still the most important therapy, disadvantages still exist. Therefore, there is an unmet need to develop effective strategies. Immunotherapy is a promising therapy.
Lile, He, Zhihong, Li
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B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity

Clinical Cancer Research, 2018
Abstract Purpose: Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non–small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby requiring alternative strategies. B7-H3, an immune-checkpoint molecule, is expressed in various malignancies.
Kimio, Yonesaka, Koji, Haratani, Shiki, Takamura, Hitomi, Sakai, Ryoji, Kato, Naoki, Takegawa, Takayuki, Takahama, Kaoru, Tanaka, Hidetoshi, Hayashi, Masayuki, Takeda, Sigeki, Kato, Osamu, Maenishi, Kazuko, Sakai, Yasutaka, Chiba, Takafumi, Okabe, Keita, Kudo, Yoshikazu, Hasegawa, Hiroyasu, Kaneda, Michiko, Yamato, Kenji, Hirotani, Masaaki, Miyazawa, Kazuto, Nishio, Kazuhiko, Nakagawa   +22 more
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