Results 201 to 206 of about 12,335 (206)

B7-H3 is spliced by SRSF3 in colorectal cancer

Cancer Immunology, Immunotherapy, 2020
B7-H3, an important co-inhibitor, is abnormally highly expressed in a variety of malignancies. The antibodies targeting B7-H3 have exhibited beneficial therapeutic effects in clinical trials. Therefore, discovery of the regulatory factors in B7-H3 expression may provide new strategies for tumor therapy.
Chunxia Zhang, Yinshuang Chen, Fuchao Li, Man Yang, Fanyi Meng, Yawen Zhang, Weichang Chen, Weipeng Wang   +7 more
openaire   +2 more sources

B7-H3 targeted antibody-based immunotherapy of malignant diseases

Expert Opinion on Biological Therapy, 2020
Introduction: Recent advances in immuno-oncology and bioengineering have rekindled the interest in monoclonal antibody (mAb)-based immunotherapies for malignancies. Crucial for their success is the identification of tumor antigens (TAs) that can serve as targets. B7-H3, a member of the B7 ligand family, represents such a TA.
Theodoros Michelakos, Filippos Kontos, Omar Barakat, Luke Maggs, Joseph H. Schwab, Cristina R. Ferrone, Soldano Ferrone   +6 more
openaire   +2 more sources

B7-H3: A promising therapeutic target for autoimmune diseases

Cellular Immunology, 2020
B7-H3 as a newly identified costimulatory molecule that belongs to B7 ligand family, is broadly expressed in both lymphoid and non-lymphoid tissues. The overexpression of B7-H3 has been verified to be correlated with the poor prognosis and poor clinical outcome of several human cancers.
Yuting, Chen, Shi-Yang, Guan, Jixiang, Deng, Hui, Yang, Wei, Xu, Shanshan, Xu, Ming, Shao, Xing, Gao, Shengqian, Xu, Zongwen, Shuai, Faming, Pan   +10 more
openaire   +2 more sources

Genome-wide identification and evolutionary analysis of B7-H3

International Journal of Data Mining and Bioinformatics, 2012
B7-H3 is an immune co-stimulatory molecule of the B7 family that contains a set of immunoglobulin-V (IgV) and immunoglobulin-C (IgC) domains. To explore the evolutionary process of B7-H3 gene, we conducted a genome-wide structure and phylogenetic analysis of B7-H3 genes in currently sequenced genomes. On the basis of the available data, 17 mammalian B7-
Hairong, Duan, Moli, Huang
openaire   +2 more sources

[Expression and clinical significance of costimulatory molecule B7-H3 mRNA and B7-H3 protein in gastric carcinoma].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2010
To study the expression of B7-H3 mRNA and B7-H3 protein in gastric carcinoma and their clinical significance.The expression of B7-H3 mRNA and B7-H3 protein in gastric carcinoma and the nearby normal tissue of 38 patients was detected by real-time RT-PCR and immunohistochemical assay respectively.B7-H3 mRNA was expressed both in gastric carcinoma and ...
Jie-min, Zhao, Chang-ping, Wu, Rong-chao, Wang, Jun, Xu, Jiang, Zhu, Jiang, Wei, Guang-hua, Luo, Liang-rong, Shi, Min, Tan, Yan, Tan   +9 more
openaire   +1 more source

B7-H3 and Prostate Cancer: New Therapeutic Dance Partners

European Urology, 2023
Eugene, Shenderov, Emmanuel S, Antonarakis   +1 more
openaire   +2 more sources