Results 21 to 30 of about 12,335 (206)
Cell Death and Disease, 2021 Emerging evidence suggests that cellular senescence induced by chemotherapy has been recognized as a new weapon for cancer therapy. This study aimed to research novel functions of B7-H3 in cellular senescence induced by a low dose of doxorubicin (DOX) in
Ruoqin Wang +9 more
doaj +1 more source
Evidence Supporting a Role for the Immune Checkpoint Protein B7-H3 in NK Cell-Mediated Cytotoxicity Against AML [PDF]
, 2022 We observed that the immune checkpoint protein B7-H3 is overexpressed in acute myeloid leukemia (AML) patients with poor treatment outcomes. Inhibition of B7-H3 expression or blocking of its activity using a novel monoclonal antibody (T-1A5) in AML cells
Battula, V Lokesh +8 more
core +2 more sources
Mouse B7-H3 induces antitumor immunity [PDF]
Gene Therapy, 2003 Members of the B7 family costimulate the proliferation of lymphocytes during the initiation and maintenance of antigen-specific humoral and cell-mediated immune responses. While B7-1 and -2 are restricted to lymphoid tissues, and activate naïve T cells, recently identified members including B7-H2 and -H3 are widely expressed on nonlymphoid tissues, and
X, Sun +5 more
openaire +2 more sources
Frontiers in Oncology, 2021 B7-H3 is an immunomodulatory member of the B7-superfamily with limited expression in normal tissues, but overexpression in several types of cancer. Therefore it is currently being explored as a potential target for cancer immunotherapy.
Emma E. Geerdes +8 more
doaj +1 more source
The contrasting role of B7-H3 [PDF]
Proceedings of the National Academy of Sciences, 2008 Tlymphocytes of adaptive immunity provide vertebrates with the ability to survey for and respond specifically to an incredible diversity of antigens, whether foreign or native. Appropriate T cell response is required to eradicate pathogens, whereas abnormal T cell function could lead to autoimmune diseases, cancer, and transplantation rejection.
Kimberly A, Hofmeyer +2 more
openaire +2 more sources
B7-H3 in Cancer – Beyond Immune Regulation [PDF]
Trends in Cancer, 2018 B7-H3, a member of the B7 family of immunoregulatory proteins, is overexpressed in cancer and promotes tumor growth, metastasis, and drug resistance. We discuss here the involvement of B7-H3 in cancer that goes beyond its immune regulatory function, and discuss the potential of B7-H3 as a biomarker and therapeutic target.
Karlsen, Karine Flem +3 more
openaire +4 more sources
Cancer Medicine, 2021 The role of B7‐H3 in acute myeloid leukemia (AML) is not fully understood. Two previous studies investigating its expression and significances in AML are partially different.
Ling‐yi Zhang +11 more
doaj +1 more source
A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers [PDF]
, 2022 B7-H3 (CD276) has emerged as a target for cancer immunotherapy by virtue of consistent expression in many malignancies, relative absence from healthy tissues, and an emerging role as a driver of tumor immune inhibition. Recent studies have reported B7-H3
Alonso-Ferrero, M +13 more
core +1 more source
BMC Endocrine Disorders, 2020 Background Type 1 Diabetes (T1D) is a T cell-mediated autoimmune disorder caused by the destruction of insulin-secreting cells. B7-H3 (CD276) plays a vital role in T cell response.
Sisi Ding +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Background: B7-H3, also known as CD276, an important immune checkpoint member of the B7-CD28 family, is confirmed as a promising target after PD-L1 in clinical trials.
Bohui Zhao +10 more
doaj +1 more source