Results 41 to 50 of about 12,335 (206)

Characterization of Mouse and Human B7-H3 Genes [PDF]

The Journal of Immunology, 2002
Abstract T cell activation and immune function are regulated by costimulatory molecules of the B7 superfamily. Human B7-H3 is a recent addition to this family and has been shown to mediate T cell proliferation and IFN-γ production. In this work we describe the identification of the mouse B7-H3 homolog, which is ubiquitously expressed in ...
Mingyi, Sun, Sabrina, Richards, Durbaka V R, Prasad, Xoi Muoi, Mai, Alexander, Rudensky, Chen, Dong   +5 more
openaire   +2 more sources

Hopes on immunotherapy targeting B7-H3 in neuroblastoma

Translational Oncology, 2023
Neuroblastoma is one of the most aggressive cancer forms in children, with highly heterogenous clinical manifestations ranging from spontaneous regression to high metastatic capacity. High-risk neuroblastoma has the highest mortality rates of all pediatric cancers, highlighting the urgent need for effective novel therapeutic interventions. B7-H3 immune
Rafael Pulido, Caroline E. Nunes-Xavier
openaire   +3 more sources

Evaluation Challenges in the validation of B7-H3 as oral tongue cancer prognosticator [PDF]

, 2020
B7-H3 was the only molecule identified with prognostic potential from a recent systematic review of the prognostic value of immune checkpoints in oral cancer. We aimed to validate this finding in a multicenter international cohort.
Almahmoudi, Rabeia, Al‑Samadi, Ahmed, Bjerkli, Inger-Heidi, Coletta, Ricardo D., Hadler‑Olsen, Elin, Hyytiäinen, Aini, Paavonen, Timo, Rodrigues, Priscila, Salo, Tuula, Sieviläinen, Meri, Toppila‑Salmi, Sanna, Wirsing, Anna Maria, Åström, Pirjo   +12 more
core   +6 more sources

B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells

OncoImmunology, 2020
The immunoregulatory protein B7-H3, a member of the B7 family, has been confirmed to be highly expressed in colon cancer. However, the exact influence of B7-H3 on the features and antitumor ability of γδT cells in colon cancer remains unknown.
Huimin Lu, Tongguo Shi, Mingyuan Wang, Xiaomi Li, Yanzheng Gu, Xueguang Zhang, Guangbo Zhang, Weichang Chen   +7 more
doaj   +1 more source

Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival [PDF]

, 2009
MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells
Alcock, L., Bray, I., Bryan, K., Buckley, P. G., Foley, N. H., Higgins, D. G., London, W. B., McGrady, P. W., Mestdagh, Pieter, Murphy, D. M., O'Meara, A., O'Sullivan, M., Prenter, S., Speleman, Franki, Stallings, R. L., Vandesompele, Jo   +15 more
core   +7 more sources

B7-H3-Targeted CAR-T Cells Exhibit Potent Antitumor Effects on Hematologic and Solid Tumors

Molecular Therapy: Oncolytics, 2020
Recently, B7-H3 was frequently reported to be overexpressed in various cancer types and has been suggested to be a promising target for cancer immunotherapy. In the present study, we analyzed the mRNA expression of B7-H3 in The Cancer Genome Atlas (TCGA)
Zongliang Zhang, Caiying Jiang, Zhiyong Liu, Meijia Yang, Xin Tang, Yuelong Wang, Meijun Zheng, Jianhan Huang, Kunhong Zhong, Shasha Zhao, Mei Tang, Tingyue Zhou, Hui Yang, Gang Guo, Liangxue Zhou, Jianguo Xu, Aiping Tong   +16 more
doaj   +1 more source

Co-deficiency of B7-H3 and B7-H4 identifies high CD8 + T cell infiltration and better prognosis in pancreatic cancer

BMC Cancer, 2022
Background Immunotherapy is a novel hotspot for the treatment of pancreatic adenocarcinoma (PAAD). However, potential biomarkers which could identify the inflamed tumor microenvironment (TME) are urgently required.
Shuping Si, Lei Wang, Hui Cao, Yuhua Xu, Qiang Zhan   +4 more
doaj   +1 more source

A Novel Anti-B7-H3 × Anti-CD3 Bispecific Antibody with Potent Antitumor Activity

Life, 2022
B7-H3 plays an important role in tumor apoptosis, proliferation, adhesion, angiogenesis, invasion, migration, and evasion of immune surveillance. It is overexpressed in various human solid tumor tissues.
Yan Feng, Kun Xie, Yanxin Yin, Bingyu Li, Chenyu Pi, Xiaoqing Xu, Tao Huang, Jingming Zhang, Bo Wang, Hua Gu, Jianmin Fang   +10 more
doaj   +1 more source

Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

Journal of Hematology & Oncology, 2021
Background B7-H3, an immune-checkpoint molecule and a transmembrane protein, is overexpressed in non-small cell lung cancer (NSCLC), making it an attractive therapeutic target.
Jie Liu, Shuo Yang, Bihui Cao, Guangyu Zhou, Fengjuan Zhang, Yuan Wang, Rixin Wang, Lipeng Zhu, Ya Meng, Cong Hu, Hui Liang, Xu Lin, Kangshun Zhu, Guokai Chen, Kathy Qian Luo, Lijun Di, Qi Zhao   +16 more
doaj   +1 more source

B7‐H3‐mediated tumor immunology: Friend or foe? [PDF]

International Journal of Cancer, 2013
B7‐H3 (CD276), a newly identified member of the B7 family of molecules, is often induced in human tumors and its overexpression is closely correlated with survival, prognosis or tumor grade. Although cancer immunotherapy has not been completely translated into clinical successes, interest has been further enhanced by the realization of these ...
Ling, Wang, Fu-Biao, Kang, Bao-En, Shan
openaire   +2 more sources