Results 51 to 60 of about 12,335 (206)

Investigating the Anti-tumorigenic Properties of Synthetic Inhibitors of B7-H3 in Group 3 Medulloblastoma [PDF]

, 2021
Medulloblastomas (MB) are devastating brain tumors originating in the cerebellum most commonly in children. There are four distinct subgroups of medulloblastoma: WNT (wingless), SHH (sonic hedgehog), group 3, and group 4.
Doss, David J., Kanchan, Ranjana K., Mahapatra, Sidharth, Patel, Sonia, Perumal, Naveenkumar, Trippier, Paul C.   +5 more
core   +1 more source

Large-scale analysis reveals the specific clinical and immune features of B7-H3 in glioma

OncoImmunology, 2018
Background: B7-H3 is an immune checkpoint member that belongs to B7-CD28 families and plays a vital role in the inhibition of T-cell function. Importantly, B7-H3 is widely overexpressed on solid tumors, making it become an attractive target for cancer ...
Chaoqi Zhang, Zhen Zhang, Feng Li, Zhibo Shen, Yamin Qiao, Lifeng Li, Shasha Liu, Mengjia Song, Xuan Zhao, Feifei Ren, Qianyi He, Bo Yang, Ruitai Fan, Yi Zhang   +13 more
doaj   +1 more source

B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma

Frontiers in Oncology, 2021
Objectivechordomas are rare bone tumors with few therapeutic options. Skull base and sacrum are the two most common origin sites. Immunotherapies are emerging as the most promising approaches to fight various cancers.
Cheng Long, Gaowei Li, Chengyun Zhang, Tao Jiang, Yanjun Li, Xin Duan, Gang Zhong   +6 more
doaj   +1 more source

Targeting radiation-resistant prostate cancer stem cells by B7-H3 CAR T cells [PDF]

, 2021
Radiotherapy (RT) is a key treatment for prostate cancer. However, RT resistance can contribute to treatment failure. Prostate cancer stem cells (PCSCs) are radioresistant.
DeLeo A.B, Dotti G, Fan S, Ferrone S, Gao X, He L, Ma T, Sadagopan A, Sun R, Wang D, Wang G, Wang X, Wang Y, Yu L, Zhang L, Zhang Y, Zheng H   +16 more
core   +2 more sources

B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway

Chinese Medical Journal, 2023
. Background:. Cancer stem-like cells (CSCs) are a small subset of cells in tumors that exhibit self-renewal and differentiation properties. CSCs play a vital role in tumor formation, progression, relapse, and therapeutic resistance.
Lu Xia, Yuqi Chen, Juntao Li, Jiayu Wang, Kanger Shen, Anjing Zhao, Haiyan Jin, Guangbo Zhang, Qinhua Xi, Suhua Xia, Tongguo Shi, Rui Li, Jinjiao Li, Yuanyuan Ji   +13 more
doaj   +1 more source

B7‐H3 protein expression in acute myeloid leukemia [PDF]

Cancer Medicine, 2015
AbstractCostimulatory molecules are essential regulators of the immunological synapse and enable the fine‐tuning of the immune response. These mechanisms are subverted by cancer cells to evade immunosurveillance. The B7 family of costimulatory molecules comprises several ligands that may contribute to immunoescape. B7‐H3 [B7‐homolog 3 or CD276] remains
Guery, Thomas, Roumier, Christophe, Berthon, Celine, Renneville, Aline, Preudhomme, Claude, Quesnel, Bruno   +5 more
openaire   +2 more sources

B7‐H3 promotes acute and chronic allograft rejection [PDF]

European Journal of Immunology, 2005
Abstract The B7 homolog B7‐H3 is important for the regulation of immune responses though its functions in vivo are controversial. We report the first clinical and experimental data concerning expression and function of B7‐H3 in alloresponses. Immunohistological and molecular
Liqing, Wang, Christopher C, Fraser, Kristine, Kikly, Andrew D, Wells, Rongxiang, Han, Anthony J, Coyle, Lieping, Chen, Wayne W, Hancock   +7 more
openaire   +2 more sources

Overexpression of B7-H3 in α-SMA-Positive Fibroblasts Is Associated With Cancer Progression and Survival in Gastric Adenocarcinomas

Frontiers in Oncology, 2020
Background: B7-H3 promotes tumor immune escape and is highly expressed in tumor tissues. Stromal cells in tumors, including fibroblasts, play an important role in this process; however, the role of B7-H3 in tumor fibroblasts has not been fully clarified ...
Shenghua Zhan, Zhiju Liu, Min Zhang, Tianwei Guo, Qiuying Quan, Lili Huang, Lingchuan Guo, Lei Cao, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang   +10 more
doaj   +1 more source

B7-H3-liquid biopsy for the characterization and monitoring of the dynamic biology of prostate cancer [PDF]

BackgroundB7-H3 is a promising target for cancer therapy, notably in prostate cancer (PCa), particularly in metastatic, castration-resistant PCa (mCRPC).
Chen, Jie-Fu, Chen, Zijing, Gevorkian, Lilit, Gong, Jun, Ji, You-Ren, Ju, Yong, Kim, Hyoyong, Lee, Junseok, Phung, Aaron, Posadas, Edwin M, Salumbides, Brenda, Scher, Kevin, Tseng, Hsian-Rong, Tu, Kai Han, Wang, Jasmine J, Watson, Joshua, Yen, Ying-Tzu, You, Sungyong, Zhang, Ryan Y, Zhao, Chen, Zhu, Yazhen   +20 more
core   +1 more source

Expressions of B7-H4 and B7-H3 Proteins and Effect of Sorafenib on their Expressions in Different Human Hepatoma Cell Lines [PDF]

, 2015
Purpose: To study whether B7-H3 and B7-H4 proteins can be candidate drug targets for preventing and treating hepatoma.Methods: Western blot assay was used to study the expressions of B7-H3 and B7-H4 proteins and the effect of sorafenib on their ...
Li, Kun, Liu, Wei-Xin, Long, Ji-Fu, Shen, Ya-Ping, Wang, Li-Zhou, Yang, Xi-Yuan, Zhang, Shuai, Zhou, Shi   +7 more
core   +2 more sources