Results 61 to 70 of about 12,335 (206)

B7-H3 in Medulloblastoma-Derived Exosomes

International Journal of Molecular Sciences, 2020
(1) Aim: Medulloblastoma is the most common aggressive pediatric cancer of the central nervous system. Improved therapies are necessary to improve life outcomes for medulloblastoma patients. Exosomes are a subset of extracellular vesicles that are excreted outside of the cell, and can transport nucleic acids and proteins from donor cells to nearby ...
Purvis, Ian J., Velpula, Kiran K., Guda, Maheedhara R., Nguyen, Daniel, Tsung, Andrew J., Asuthkar, Swapna   +5 more
openaire   +1 more source

Development of novel B7-H3 targeted CAR therapy for neuroblastoma [PDF]

, 2021
Despite improvements in treatment of childhood cancer, many childhood solid tumours, including high risk neuroblastoma, continue to have poor outcomes with high levels of mortality and morbidity associated with current treatment regimens.
Birley, Kathleen
core  

Overexpression of B7-H3 Is Associated With Poor Prognosis in Laryngeal Cancer

Frontiers in Oncology, 2021
The immune checkpoint molecule, B7-H3, which belongs to the B7 family, has been shown to be overexpressed in various cancers. Its role in tumors is not well defined, and many studies suggest that it is associated with poor clinical outcomes.
Yixuan Li, Qian Cai, Ximing Shen, Xiaoting Chen, Zhong Guan   +4 more
doaj   +1 more source

B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration [PDF]

, 2016
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by an excessive inflammatory response within the lungs and severely impaired gas exchange resulting from alveolar-capillary barrier disruption and pulmonary edema ...
Foley, Niamh M., Huang, Jie, Li, Yan, Li, Yi Ping, Pan, Jian, Redmond, H. Paul, Wang, Jian, Wang, Jiang Huai, Xu, Yunyun   +8 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

B7‐H3 is a potent inhibitor of human T‐cell activation: No evidence for B7‐H3 and TREML2 interaction [PDF]

European Journal of Immunology, 2009
AbstractB7‐H3 belongs to the B7 superfamily, a group of molecules that costimulate or down‐modulate T‐cell responses. Although it was shown that B7‐H3 could inhibit T‐cell responses, several studies – most of them performed in murine systems – found B7‐H3 to act in a costimulatory manner.
Judith, Leitner, Christoph, Klauser, Winfried F, Pickl, Johannes, Stöckl, Otto, Majdic, Anaïs F, Bardet, David P, Kreil, Chen, Dong, Tomohide, Yamazaki, Gerhard, Zlabinger, Katharina, Pfistershammer, Peter, Steinberger   +11 more
openaire   +2 more sources

B7-H3 participates in human salivary gland epithelial cells apoptosis through NF-κB pathway in primary Sjögren’s syndrome

Journal of Translational Medicine, 2019
Background Primary Sjögren’s syndrome (pSS) is an autoimmune disorder mainly characterized by exocrine gland injury. Costimulatory molecules play an important role in immune-regulatory networks.
Ping Li, Ying Yang, Yi Jin, Rui Zhao, Chen Dong, Wenjie Zheng, Tianyi Zhang, Jing Li, Zhifeng Gu   +8 more
doaj   +1 more source

RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma

FEBS Open Bio, 2021
B7 homolog 3 (B7‐H3) plays an important role in tumor biology, but the molecular mechanism underlying the role of B7‐H3 in tumor metastasis remains unclear. In this article, our analysis of The Cancer Genome Atlas database suggested that B7‐H3 expression
Jinjing Xie, Meiyun Sun, Dongze Zhang, Chunyang Chen, Simin Lin, Guangbo Zhang   +5 more
doaj   +1 more source

Targeting B7-H3 inhibition-induced activation of fatty acid synthesis boosts anti-B7-H3 immunotherapy in triple-negative breast cancer. [PDF]

J Immunother Cancer
Background Triple-negative breast cancer (TNBC) is the most malignant breast cancer, highlighting the need for effective immunotherapeutic targets. The immune checkpoint molecule B7-H3 has recently gained attention as a promising therapeutic target due to its pivotal role in promoting tumorigenesis and cancer ...
Jiang Y, Qian Z, Wang C, Wu D, Liu L, Ning X, You Y, Mei J, Zhao X, Zhang Y.   +9 more
europepmc   +4 more sources

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells [PDF]

, 2014
Background:Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. CEC measured in patients with advanced cancer are thought not only to derive from damaged normal vasculature (n-CEC ...
A Ouhtit, AI Chapoval, AW Griffioen, B Croix St, C Verhoef, D J Grunhagen, D Lemke, DM McDonald, F Bertolini, F Dignat-George, GN Naumov, HR Lijnen, I Yamato, J Hagendoorn, J Kraan, J Kraan, J Kraan, J W Gratama, JA Nagy, JL Rowand, K Broll, K Hida, KH Plate, L Zimmerlin, M Crisan, MH Strijbos, N Maishi, P Carmeliet, P Steinberger, P van den Broek, PK Goon, PL Crispen, R Minhajat, R Wurth, S Seaman, S Sleijfer, SE Duff, TJ Roth, W Taal, X Qin, X Zang, Y Sun, YQ Xiong   +42 more
core   +4 more sources