Results 81 to 90 of about 12,335 (206)

Dimerization of the 4Ig isoform of B7-H3 in tumor cells mediates enhanced proliferation and tumorigenic signaling

Communications Biology
B7-H3 (CD276) has two isoforms (2Ig and 4Ig), no confirmed cognate receptor, and physiological functions that remain elusive. While differentially expressed on many solid tumors correlating with poor survival, mechanisms of how B7-H3 signals in cis ...
Margie N. Sutton, Sarah E. Glazer, Riccardo Muzzioli, Ping Yang, Seth T. Gammon, David Piwnica-Worms   +5 more
doaj   +1 more source

New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

Molecular Cancer, 2023
B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment.
Ayechew Adera Getu, Abiye Tigabu, Ming Zhou, Jianrong Lu, Øystein Fodstad, Ming Tan   +5 more
doaj   +1 more source

Impact of B7-H3 expression on metastasis, immune exhaustion and JAK/STAT and PI3K/AKT pathways in clear cell renal cell carcinoma [PDF]

Immune checkpoint inhibitors in combination with tyrosine kinase inhibitors (TKIs) are improving the response rates of advanced renal cancer patients.
Angulo, Javier C., Emaldi, Maite, Errarte, Peio, Larrinaga, Gorka, Lecumberri, David, López, José I., Marín, Ángela, Mosteiro, Lorena, Mælandsmo, Gunhild Mari, Nunes-Xavier, Caroline Elisabeth, Pulido, Rafael, Rey-Iborra, Esther, Roncier, Noémie, Øyjord, Tove Ragnhild   +13 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I-/- iPSCs for β cell replacement [PDF]

, 2022
Induced pluripotent stem cells (iPSCs) represent a source from which β cells can be derived for diabetes replacement therapy. However, their application may be hindered by immune-mediated responses. Although abrogation of major histocompatibility complex
Amabile, Angelo, Baccega, Tania, Chimienti, Raniero, Cospito, Alessandro, Lombardo, Angelo, Lombardo, Marta Tiffany, Malnati, Mauro, Manenti, Fabio, Monti, Paolo, Pellegrini, Silvia, Piemonti, Lorenzo, Sordi, Valeria, Torchio, Silvia   +12 more
core   +2 more sources

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, EarlyView.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

Unlocking Privacy in Healthcare: The Impact of Explanations on Privacy Concerns and Self‐Disclosure to Conversational Technologies

Journal of Operations Management, EarlyView.
ABSTRACT While artificial intelligence (AI)‐based conversational technologies offer exciting prospects in healthcare, the lack of transparency and elevated privacy concerns in using such technologies remain a challenge and make much‐needed information difficult to obtain while administering patient care.
Hashai Papneja, Sarv Devaraj
wiley   +1 more source

B7-H3 and B7-H4 expression in phyllodes tumors of the breast detected by RNA in situ hybridization and immunohistochemistry: Association with clinicopathological features and T-cell infiltration

Tumor Biology, 2018
Phyllodes tumors are rare biphasic breast tumors with the potential for both local recurrence and distant metastasis. The aberrant expression of B7-H3 and B7-H4 B7 molecules could be potential targets for future development of immunotherapeutic ...
Ga-Eon Kim, Nah Ihm Kim, Min Ho Park, Ji Shin Lee   +3 more
doaj   +1 more source

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

B7-H3 in acute myeloid leukemia: From prognostic biomarker to immunotherapeutic target

Chinese Medical Journal
. B7-H3 (CD276), an immune checkpoint protein of the B7 family, exhibits significant upregulation in solid tumors and hematologic malignancies, exerting a crucial role in their pathophysiology. The distinct differential expression of B7-H3 between tumors
Xiao Tan, Xiangyu Zhao, Xiangxiang Pan
doaj   +1 more source