Results 141 to 150 of about 31,066,857 (388)

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.

Blood, 2012
We conducted a clinical trial to assess adoptive transfer of T cells genetically modified to express an anti-CD19 chimeric Ag receptor (CAR). Our clinical protocol consisted of chemotherapy followed by an infusion of anti-CD19-CAR-transduced T cells and ...
J. Kochenderfer, M. Dudley, S. Feldman, W. Wilson, D. Spaner, I. Maric, M. Stetler-Stevenson, G. Phan, M. Hughes, R. Sherry, J. Yang, U. Kammula, Laura Devillier, R. Carpenter, Debbie-Ann N. Nathan, R. Morgan, C. Laurencot, S. Rosenberg   +17 more
semanticscholar   +1 more source

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. [PDF]

, 1993
Cognate interactions between antigen-presenting B and T cells play crucial roles in immunologic responses. T cells that have been activated via the crosslinking of CD3 are able to induce B cell proliferation and immunoglobulin secretion in a major ...
Kipps, TJ, Ranheim, EA
core  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?

Biomolecules, 2018
Extracellular vesicles (EVs) contribute to several pathophysiological processes and appear as emerging targets for disease diagnosis and therapy. However, successful translation from bench to bedside requires deeper understanding of EVs, in particular ...
Hélène Pollet, Louise Conrard, Anne-Sophie Cloos, Donatienne Tyteca   +3 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Editorial: The B-Side of B Cells [PDF]

Frontiers in Immunology, 2021
Alessandro Camponeschi, Marcella Visentini, Alaitz Aranburu, Sven Geissler, Maria Manuela Rosado   +4 more
openaire   +3 more sources

Stromal gene signatures in large-B-cell lymphomas.

New England Journal of Medicine, 2008
BACKGROUND The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma.
G. Lenz, George W. Wright, S. Dave, Wenming Xiao, J. Powell, Huaqing Zhao, Wei Xu, Bruce K. Tan, N. Goldschmidt, J. Iqbal, J. Vose, M. Bast, K. Fu, D. Weisenburger, T. Greiner, J. Armitage, A. Kyle, L. May, R. Gascoyne, J. Connors, G. Trøen, H. Holte, S. Kvaløy, D. Dierickx, G. Verhoef, J. Delabie, E. Smeland, P. Jares, A. Martínez, A. López-Guillermo, E. Montserrat, E. Campo, R. Braziel, T. Miller, L. Rimsza, J. Cook, B. Pohlman, J. Sweetenham, R. Tubbs, R. Fisher, E. Hartmann, A. Rosenwald, G. Ott, G. Ott, H. Müller-Hermelink, D. Wrench, T. Lister, E. Jaffe, W. Wilson, W. C. Chan, L. Staudt   +50 more
semanticscholar   +1 more source

Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation

Frontiers in Immunology, 2018
Bruton's tyrosine kinase (Btk) has a key role in the signaling pathways of receptors essential for the B lymphocyte response. Given its implication in B cell-related immunodeficiencies, leukemias/lymphomas and autoimmunity, Btk is studied intensely and ...
Sara Roman-Garcia, Sara V. Merino-Cortes, Sofia R. Gardeta, Marjolein J. W. de Bruijn, Rudi W. Hendriks, Yolanda R. Carrasco   +5 more
doaj   +1 more source

Transport of B-Vitamins in Microorganisms. VI. The Non-specificity of the Effect of Exogeneous ATP on the Uptake of Labelled Thiamine by Non-proliferating Thiamine Deficient Cells of L. fermenti. A Reappraisal. [PDF]

, 1966
Halina Y. Neujahr, Sigurd H. From, Stig D. Schultz‐Haudt, E. Kulonen, J. Brunvoll, E. Bunnenberg, Carl Djerassi, Ruth Records   +7 more
openalex   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source